TY - JOUR
T1 - Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19
AU - BELLAN, Mattia
AU - BARICICH, Alessio
AU - Patrucco, F.
AU - ZEPPEGNO, Patrizia
AU - Gramaglia, Carla Maria
AU - Balbo, P. E.
AU - CARRIERO, Alessandro
AU - Amico, C. S.
AU - AVANZI, Gian Carlo
AU - Barini, M.
AU - Battaglia, M.
AU - Bor, S.
AU - CANTALUPPI, Vincenzo
AU - CAPPELLANO, GIUSEPPE
AU - Ceruti, F.
AU - CHIOCCHETTI, Annalisa
AU - Clivati, E.
AU - Giordano, M.
AU - Cuneo, D.
AU - Gambaro, E.
AU - Gattoni, E.
AU - Loro, A.
AU - MANFREDI, MARCELLO
AU - Morosini, U.
AU - Murano, F.
AU - Paracchini, E.
AU - Patti, Giuseppe Rocco Salvatore
AU - PINATO, David James
AU - RAINERI, DAVIDE
AU - ROLLA, Roberta
AU - SAINAGHI, Pier Paolo
AU - Tricca, S.
AU - PIRISI, Mario
PY - 2021
Y1 - 2021
N2 - Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363–369] days, 79 patients (39.5%) reported at least one symptom. A DLCO < 80% was observed in 96 patients (49.0%). Severe DLCO impairment (< 60%) was reported in 20 patients (10.2%), related to extent of CT scan abnormalities. Some degree of motor impairment was observed in 25.8% of subjects. 37/200 patients (18.5%) showed moderate-to-severe PTS symptoms. In the time elapsed from 4 to 12 months after hospital discharge, motor function improves, while respiratory function does not, being accompanied by evidence of lung structural damage. Symptoms remain highly prevalent one year after acute illness.
AB - Many coronavirus disease 2019 (Covid-19) survivors show symptoms months after acute illness. The aim of this work is to describe the clinical evolution of Covid-19, one year after discharge. We performed a prospective cohort study on 238 patients previously hospitalized for Covid-19 pneumonia in 2020 who already underwent clinical follow-up 4 months post-Covid-19. 200 consented to participate to a 12-months clinical assessment, including: pulmonary function tests with diffusing lung capacity for carbon monoxide (DLCO); post-traumatic stress (PTS) symptoms evaluation by the Impact of Event Scale (IES); motor function evaluation (by Short Physical Performance Battery and 2 min walking test); chest Computed Tomography (CT). After 366 [363–369] days, 79 patients (39.5%) reported at least one symptom. A DLCO < 80% was observed in 96 patients (49.0%). Severe DLCO impairment (< 60%) was reported in 20 patients (10.2%), related to extent of CT scan abnormalities. Some degree of motor impairment was observed in 25.8% of subjects. 37/200 patients (18.5%) showed moderate-to-severe PTS symptoms. In the time elapsed from 4 to 12 months after hospital discharge, motor function improves, while respiratory function does not, being accompanied by evidence of lung structural damage. Symptoms remain highly prevalent one year after acute illness.
UR - https://iris.uniupo.it/handle/11579/159449
U2 - 10.1038/s41598-021-01215-4
DO - 10.1038/s41598-021-01215-4
M3 - Article
SN - 2045-2322
VL - 11
SP - 22666
JO - Scientific Reports
JF - Scientific Reports
IS - 1
ER -