Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort

Nicolas Casco; Alberto Levi Jorge; Domingo Juan Palmero; Jan-Willem Alffenaar; Greg J Fox; Wafaa Ezz; Jin-Gun Cho; Justin Denholm; Alena Skrahina; Varvara Solodovnikova; Marcos Abdo Arbex; Tatiana Alves; Marcelo Fouad Rabahi; Giovana Rodrigues Pereira; Roberta Sales; Denise Rossato Silva; Muntasir M Saffie; Nadia Escobar Salinas; Ruth Caamaño Miranda; Catalina Cisterna; Clorinda Concha; Israel Fernandez; Claudia Villalón; Carolina Guajardo Vera; Patricia Gallegos Tapia; Viviana Cancino; Monica Carbonell; Arturo Cruz; Eduardo Muñoz; Camila Muñoz; Indira Navarro; Rolando Pizarro; Gloria Pereira Cristina Sánchez; Maria Soledad Vergara Riquelme; Evelyn Vilca; Aline Soto; Ximena Flores; Ana Garavagno; Martina Hartwig Bahamondes; Luis Moyano Merino; Ana María Pradenas; Macarena Espinoza Revillot; Patricia Rodriguez; Angeles Serrano Salinas; Carolina Taiba; Joaquín Farías Valdés; Jorge Navarro Subiabre; Carlos Ortega; Sofia Palma; Patricia Perez Castillo; Mónica Pinto; Francisco Rivas Bidegain; Margarita Venegas; Edith Yucra; Yang Li; Andres Cruz; Beatriz Guelvez; Regina Victoria Plaza; Kelly Yoana Tello Hoyos; José Cardoso-Landivar; Martin Van Den Boom; Claire Andréjak; François-Xavier Blanc; Samir Dourmane; Antoine Froissart; Armine Izadifar; Frédéric Rivière; Frédéric Schlemmer; Katerina Manika; Boubacar Djelo Diallo; Souleymane Hassane-Harouna; Norma Artiles; Licenciada Andrea Mejia; Nitesh Gupta; Pranav Ish; Gyanshankar Mishra; Jigneshkumar M Patel; Rupak Singla; Zarir F Udwadia; Francesca Alladio; Fabio Angeli; Andrea CALCAGNO; Rosella Centis; Luigi Ruffo Codecasa; Angelo De Lauretis; Susanna M R Esposito; Beatrice Formenti; Alberto Gaviraghi; Vania Giacomet; Delia Goletti; Gina Gualano; Alberto Matteelli; Giovanni Battista Migliori; Ilaria Motta; Fabrizio Palmieri; Emanuele Pontali; Tullio Prestileo; Niccolò Riccardi; Laura Saderi; Matteo Saporiti; Giovanni Sotgiu; Antonio Spanevello; Claudia Stochino; Marina Tadolini; Alessandro Torre; Simone Villa; Dina Visca; Xhevat Kurhasani; Mohammed Furjani; Najia Rasheed; Edvardas Danila; Saulius Diktanas; Ruy López Ridaura; Fátima Leticia Luna López; Marcela Muñoz Torrico; Adrian Rendon; Onno W Akkerman; Onyeaghala Chizaram; Seif Al-Abri; Fatma Alyaquobi; Khalsa Althohli; Sarita Aguirre; Rosarito Coronel Teixeira; Viviana De Egea; Sandra Irala; Angélica Medina; Guillermo Sequera; Natalia Sosa; Fátima Vázquez; Félix K Llanos-Tejada; Selene Manga; Renzo Villanueva-Villegas; David Araujo; Raquel DuarteTânia Sales Marques; Adriana Socaci; Olga Barkanova; Maria Bogorodskaya; Sergey Borisov; Andrei Mariandyshev; Anna Kaluzhenina; Tatjana Adzic Vukicevic; Maja Stosic; Darius Beh; Deborah Ng; Catherine W M Ong; Ivan Solovic; Keertan Dheda; Phindile Gina; José A Caminero; Maria Luiza De Souza Galvão; Angel Dominguez-Castellano; José-María García-García; Israel Molina Pinargote; Sarai Quirós Fernandez; Adrián Sánchez-Montalvá; Eva Tabernero Huguet; Miguel Zabaleta Murguiondo; Pierre-Alexandre Bart; Jesica Mazza-Stalder; Lia D'Ambrosio; Phalin Kamolwat; Freya Bakko; James Barnacle; Sophie Bird; Annabel Brown; Shruthi Chandran; Kieran Killington; Kathy Man; Padmasayee Papineni; Flora Ritchie; Simon Tiberi; Natasa Utjesanovic; Dominik Zenner; Jasie L Hearn; Scott Heysell; Laura Young

doi:10.1183/13993003.00925-2023

Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort

Nicolas Casco, Alberto Levi Jorge, Domingo Juan Palmero, Jan-Willem Alffenaar, Greg J Fox, Wafaa Ezz, Jin-Gun Cho, Justin Denholm, Alena Skrahina, Varvara Solodovnikova, Marcos Abdo Arbex, Tatiana Alves, Marcelo Fouad Rabahi, Giovana Rodrigues Pereira, Roberta Sales, Denise Rossato Silva, Muntasir M Saffie, Nadia Escobar Salinas, Ruth Caamaño Miranda, Catalina CisternaClorinda Concha, Israel Fernandez, Claudia Villalón, Carolina Guajardo Vera, Patricia Gallegos Tapia, Viviana Cancino, Monica Carbonell, Arturo Cruz, Eduardo Muñoz, Camila Muñoz, Indira Navarro, Rolando Pizarro, Gloria Pereira Cristina Sánchez, Maria Soledad Vergara Riquelme, Evelyn Vilca, Aline Soto, Ximena Flores, Ana Garavagno, Martina Hartwig Bahamondes, Luis Moyano Merino, Ana María Pradenas, Macarena Espinoza Revillot, Patricia Rodriguez, Angeles Serrano Salinas, Carolina Taiba, Joaquín Farías Valdés, Jorge Navarro Subiabre, Carlos Ortega, Sofia Palma, Patricia Perez Castillo, Mónica Pinto, Francisco Rivas Bidegain, Margarita Venegas, Edith Yucra, Yang Li, Andres Cruz, Beatriz Guelvez, Regina Victoria Plaza, Kelly Yoana Tello Hoyos, José Cardoso-Landivar, Martin Van Den Boom, Claire Andréjak, François-Xavier Blanc, Samir Dourmane, Antoine Froissart, Armine Izadifar, Frédéric Rivière, Frédéric Schlemmer, Katerina Manika, Boubacar Djelo Diallo, Souleymane Hassane-Harouna, Norma Artiles, Licenciada Andrea Mejia, Nitesh Gupta, Pranav Ish, Gyanshankar Mishra, Jigneshkumar M Patel, Rupak Singla, Zarir F Udwadia, Francesca Alladio, Fabio Angeli, Andrea CALCAGNO, Rosella Centis, Luigi Ruffo Codecasa, Angelo De Lauretis, Susanna M R Esposito, Beatrice Formenti, Alberto Gaviraghi, Vania Giacomet, Delia Goletti, Gina Gualano, Alberto Matteelli, Giovanni Battista Migliori, Ilaria Motta, Fabrizio Palmieri, Emanuele Pontali, Tullio Prestileo, Niccolò Riccardi, Laura Saderi, Matteo Saporiti, Giovanni Sotgiu, Antonio Spanevello, Claudia Stochino, Marina Tadolini, Alessandro Torre, Simone Villa, Dina Visca, Xhevat Kurhasani, Mohammed Furjani, Najia Rasheed, Edvardas Danila, Saulius Diktanas, Ruy López Ridaura, Fátima Leticia Luna López, Marcela Muñoz Torrico, Adrian Rendon, Onno W Akkerman, Onyeaghala Chizaram, Seif Al-Abri, Fatma Alyaquobi, Khalsa Althohli, Sarita Aguirre, Rosarito Coronel Teixeira, Viviana De Egea, Sandra Irala, Angélica Medina, Guillermo Sequera, Natalia Sosa, Fátima Vázquez, Félix K Llanos-Tejada, Selene Manga, Renzo Villanueva-Villegas, David Araujo, Raquel DuarteTânia Sales Marques, Adriana Socaci, Olga Barkanova, Maria Bogorodskaya, Sergey Borisov, Andrei Mariandyshev, Anna Kaluzhenina, Tatjana Adzic Vukicevic, Maja Stosic, Darius Beh, Deborah Ng, Catherine W M Ong, Ivan Solovic, Keertan Dheda, Phindile Gina, José A Caminero, Maria Luiza De Souza Galvão, Angel Dominguez-Castellano, José-María García-García, Israel Molina Pinargote, Sarai Quirós Fernandez, Adrián Sánchez-Montalvá, Eva Tabernero Huguet, Miguel Zabaleta Murguiondo, Pierre-Alexandre Bart, Jesica Mazza-Stalder, Lia D'Ambrosio, Phalin Kamolwat, Freya Bakko, James Barnacle, Sophie Bird, Annabel Brown, Shruthi Chandran, Kieran Killington, Kathy Man, Padmasayee Papineni, Flora Ritchie, Simon Tiberi, Natasa Utjesanovic, Dominik Zenner, Jasie L Hearn, Scott Heysell, Laura Young

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods: We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both. Results: Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19 versus those dying because of either TB or COVID-19 alone (p<0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95% CI 1.03-1.07), HIV infection (HR 2.29, 95% CI 1.02-5.16) and invasive ventilation (HR 4.28, 95% CI 2.34-7.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95% CI 1.02-1.04), male sex (HR 2.21, 95% CI 1.24-3.91), oxygen requirement (HR 7.93, 95% CI 3.44-18.26) and invasive ventilation (HR 2.19, 95% CI 1.36-3.53). Conclusions: In our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes.

Lingua originale	Inglese
pagine (da-a)	1-12
Numero di pagine	12
Rivista	European Respiratory Journal
Volume	62
Numero di pubblicazione	5
DOI	https://doi.org/10.1183/13993003.00925-2023
Stato di pubblicazione	Pubblicato - 2023

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Accesso al documento

10.1183/13993003.00925-2023

https://hdl.handle.net/11579/216975

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Cita questo

Casco, N., Jorge, A. L., Palmero, D. J., Alffenaar, J.-W., Fox, G. J., Ezz, W., Cho, J.-G., Denholm, J., Skrahina, A., Solodovnikova, V., Arbex, M. A., Alves, T., Rabahi, M. F., Pereira, G. R., Sales, R., Silva, D. R., Saffie, M. M., Salinas, N. E., Miranda, R. C., ... Young, L. (2023). Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort. European Respiratory Journal, 62(5), 1-12. https://doi.org/10.1183/13993003.00925-2023

@article{26a0fffaa0ff48209c87aef0ee99484c,

title = "Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort",

abstract = "Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods: We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both. Results: Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8\% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19 versus those dying because of either TB or COVID-19 alone (p<0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95\% CI 1.03-1.07), HIV infection (HR 2.29, 95\% CI 1.02-5.16) and invasive ventilation (HR 4.28, 95\% CI 2.34-7.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95\% CI 1.02-1.04), male sex (HR 2.21, 95\% CI 1.24-3.91), oxygen requirement (HR 7.93, 95\% CI 3.44-18.26) and invasive ventilation (HR 2.19, 95\% CI 1.36-3.53). Conclusions: In our global cohort, death was the outcome in >10\% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes.",

author = "Nicolas Casco and Jorge, \{Alberto Levi\} and Palmero, \{Domingo Juan\} and Jan-Willem Alffenaar and Fox, \{Greg J\} and Wafaa Ezz and Jin-Gun Cho and Justin Denholm and Alena Skrahina and Varvara Solodovnikova and Arbex, \{Marcos Abdo\} and Tatiana Alves and Rabahi, \{Marcelo Fouad\} and Pereira, \{Giovana Rodrigues\} and Roberta Sales and Silva, \{Denise Rossato\} and Saffie, \{Muntasir M\} and Salinas, \{Nadia Escobar\} and Miranda, \{Ruth Caama{\~n}o\} and Catalina Cisterna and Clorinda Concha and Israel Fernandez and Claudia Villal{\'o}n and Vera, \{Carolina Guajardo\} and Tapia, \{Patricia Gallegos\} and Viviana Cancino and Monica Carbonell and Arturo Cruz and Eduardo Mu{\~n}oz and Camila Mu{\~n}oz and Indira Navarro and Rolando Pizarro and \{Cristina S{\'a}nchez\}, \{Gloria Pereira\} and \{Vergara Riquelme\}, \{Maria Soledad\} and Evelyn Vilca and Aline Soto and Ximena Flores and Ana Garavagno and Bahamondes, \{Martina Hartwig\} and Merino, \{Luis Moyano\} and Pradenas, \{Ana Mar{\'i}a\} and Revillot, \{Macarena Espinoza\} and Patricia Rodriguez and Salinas, \{Angeles Serrano\} and Carolina Taiba and Vald{\'e}s, \{Joaqu{\'i}n Far{\'i}as\} and Subiabre, \{Jorge Navarro\} and Carlos Ortega and Sofia Palma and Castillo, \{Patricia Perez\} and M{\'o}nica Pinto and Bidegain, \{Francisco Rivas\} and Margarita Venegas and Edith Yucra and Yang Li and Andres Cruz and Beatriz Guelvez and \{Victoria Plaza\}, Regina and \{Tello Hoyos\}, \{Kelly Yoana\} and Jos{\'e} Cardoso-Landivar and \{Van Den Boom\}, Martin and Claire Andr{\'e}jak and Fran{\c c}ois-Xavier Blanc and Samir Dourmane and Antoine Froissart and Armine Izadifar and Fr{\'e}d{\'e}ric Rivi{\`e}re and Fr{\'e}d{\'e}ric Schlemmer and Katerina Manika and Diallo, \{Boubacar Djelo\} and Souleymane Hassane-Harouna and Norma Artiles and Mejia, \{Licenciada Andrea\} and Nitesh Gupta and Pranav Ish and Gyanshankar Mishra and Patel, \{Jigneshkumar M\} and Rupak Singla and Udwadia, \{Zarir F\} and Francesca Alladio and Fabio Angeli and Andrea CALCAGNO and Rosella Centis and Codecasa, \{Luigi Ruffo\} and \{De Lauretis\}, Angelo and Esposito, \{Susanna M R\} and Beatrice Formenti and Alberto Gaviraghi and Vania Giacomet and Delia Goletti and Gina Gualano and Alberto Matteelli and Migliori, \{Giovanni Battista\} and Ilaria Motta and Fabrizio Palmieri and Emanuele Pontali and Tullio Prestileo and Niccol{\`o} Riccardi and Laura Saderi and Matteo Saporiti and Giovanni Sotgiu and Antonio Spanevello and Claudia Stochino and Marina Tadolini and Alessandro Torre and Simone Villa and Dina Visca and Xhevat Kurhasani and Mohammed Furjani and Najia Rasheed and Edvardas Danila and Saulius Diktanas and Ridaura, \{Ruy L{\'o}pez\} and \{Luna L{\'o}pez\}, \{F{\'a}tima Leticia\} and Torrico, \{Marcela Mu{\~n}oz\} and Adrian Rendon and Akkerman, \{Onno W\} and Onyeaghala Chizaram and Seif Al-Abri and Fatma Alyaquobi and Khalsa Althohli and Sarita Aguirre and Teixeira, \{Rosarito Coronel\} and \{De Egea\}, Viviana and Sandra Irala and Ang{\'e}lica Medina and Guillermo Sequera and Natalia Sosa and F{\'a}tima V{\'a}zquez and Llanos-Tejada, \{F{\'e}lix K\} and Selene Manga and Renzo Villanueva-Villegas and David Araujo and \{Sales Marques\}, \{Raquel DuarteT{\^a}nia\} and Adriana Socaci and Olga Barkanova and Maria Bogorodskaya and Sergey Borisov and Andrei Mariandyshev and Anna Kaluzhenina and Vukicevic, \{Tatjana Adzic\} and Maja Stosic and Darius Beh and Deborah Ng and Ong, \{Catherine W M\} and Ivan Solovic and Keertan Dheda and Phindile Gina and Caminero, \{Jos{\'e} A\} and \{De Souza Galv{\~a}o\}, \{Maria Luiza\} and Angel Dominguez-Castellano and Jos{\'e}-Mar{\'i}a Garc{\'i}a-Garc{\'i}a and Pinargote, \{Israel Molina\} and Fernandez, \{Sarai Quir{\'o}s\} and Adri{\'a}n S{\'a}nchez-Montalv{\'a} and Huguet, \{Eva Tabernero\} and Murguiondo, \{Miguel Zabaleta\} and Pierre-Alexandre Bart and Jesica Mazza-Stalder and Lia D'Ambrosio and Phalin Kamolwat and Freya Bakko and James Barnacle and Sophie Bird and Annabel Brown and Shruthi Chandran and Kieran Killington and Kathy Man and Padmasayee Papineni and Flora Ritchie and Simon Tiberi and Natasa Utjesanovic and Dominik Zenner and Hearn, \{Jasie L\} and Scott Heysell and Laura Young",

year = "2023",

doi = "10.1183/13993003.00925-2023",

language = "English",

volume = "62",

pages = "1--12",

journal = "European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "5",

}

Casco, N, Jorge, AL, Palmero, DJ, Alffenaar, J-W, Fox, GJ, Ezz, W, Cho, J-G, Denholm, J, Skrahina, A, Solodovnikova, V, Arbex, MA, Alves, T, Rabahi, MF, Pereira, GR, Sales, R, Silva, DR, Saffie, MM, Salinas, NE, Miranda, RC, Cisterna, C, Concha, C, Fernandez, I, Villalón, C, Vera, CG, Tapia, PG, Cancino, V, Carbonell, M, Cruz, A, Muñoz, E, Muñoz, C, Navarro, I, Pizarro, R, Cristina Sánchez, GP, Vergara Riquelme, MS, Vilca, E, Soto, A, Flores, X, Garavagno, A, Bahamondes, MH, Merino, LM, Pradenas, AM, Revillot, ME, Rodriguez, P, Salinas, AS, Taiba, C, Valdés, JF, Subiabre, JN, Ortega, C, Palma, S, Castillo, PP, Pinto, M, Bidegain, FR, Venegas, M, Yucra, E, Li, Y, Cruz, A, Guelvez, B, Victoria Plaza, R, Tello Hoyos, KY, Cardoso-Landivar, J, Van Den Boom, M, Andréjak, C, Blanc, F-X, Dourmane, S, Froissart, A, Izadifar, A, Rivière, F, Schlemmer, F, Manika, K, Diallo, BD, Hassane-Harouna, S, Artiles, N, Mejia, LA, Gupta, N, Ish, P, Mishra, G, Patel, JM, Singla, R, Udwadia, ZF, Alladio, F, Angeli, F, CALCAGNO, A, Centis, R, Codecasa, LR, De Lauretis, A, Esposito, SMR, Formenti, B, Gaviraghi, A, Giacomet, V, Goletti, D, Gualano, G, Matteelli, A, Migliori, GB, Motta, I, Palmieri, F, Pontali, E, Prestileo, T, Riccardi, N, Saderi, L, Saporiti, M, Sotgiu, G, Spanevello, A, Stochino, C, Tadolini, M, Torre, A, Villa, S, Visca, D, Kurhasani, X, Furjani, M, Rasheed, N, Danila, E, Diktanas, S, Ridaura, RL, Luna López, FL, Torrico, MM, Rendon, A, Akkerman, OW, Chizaram, O, Al-Abri, S, Alyaquobi, F, Althohli, K, Aguirre, S, Teixeira, RC, De Egea, V, Irala, S, Medina, A, Sequera, G, Sosa, N, Vázquez, F, Llanos-Tejada, FK, Manga, S, Villanueva-Villegas, R, Araujo, D, Sales Marques, RD, Socaci, A, Barkanova, O, Bogorodskaya, M, Borisov, S, Mariandyshev, A, Kaluzhenina, A, Vukicevic, TA, Stosic, M, Beh, D, Ng, D, Ong, CWM, Solovic, I, Dheda, K, Gina, P, Caminero, JA, De Souza Galvão, ML, Dominguez-Castellano, A, García-García, J-M, Pinargote, IM, Fernandez, SQ, Sánchez-Montalvá, A, Huguet, ET, Murguiondo, MZ, Bart, P-A, Mazza-Stalder, J, D'Ambrosio, L, Kamolwat, P, Bakko, F, Barnacle, J, Bird, S, Brown, A, Chandran, S, Killington, K, Man, K, Papineni, P, Ritchie, F, Tiberi, S, Utjesanovic, N, Zenner, D, Hearn, JL, Heysell, S & Young, L 2023, 'Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort', European Respiratory Journal, vol. 62, n. 5, pagg. 1-12. https://doi.org/10.1183/13993003.00925-2023

TY - JOUR

T1 - Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort

AU - Casco, Nicolas

AU - Jorge, Alberto Levi

AU - Palmero, Domingo Juan

AU - Alffenaar, Jan-Willem

AU - Fox, Greg J

AU - Ezz, Wafaa

AU - Cho, Jin-Gun

AU - Denholm, Justin

AU - Skrahina, Alena

AU - Solodovnikova, Varvara

AU - Arbex, Marcos Abdo

AU - Alves, Tatiana

AU - Rabahi, Marcelo Fouad

AU - Pereira, Giovana Rodrigues

AU - Sales, Roberta

AU - Silva, Denise Rossato

AU - Saffie, Muntasir M

AU - Salinas, Nadia Escobar

AU - Miranda, Ruth Caamaño

AU - Cisterna, Catalina

AU - Concha, Clorinda

AU - Fernandez, Israel

AU - Villalón, Claudia

AU - Vera, Carolina Guajardo

AU - Tapia, Patricia Gallegos

AU - Cancino, Viviana

AU - Carbonell, Monica

AU - Cruz, Arturo

AU - Muñoz, Eduardo

AU - Muñoz, Camila

AU - Navarro, Indira

AU - Pizarro, Rolando

AU - Cristina Sánchez, Gloria Pereira

AU - Vergara Riquelme, Maria Soledad

AU - Vilca, Evelyn

AU - Soto, Aline

AU - Flores, Ximena

AU - Garavagno, Ana

AU - Bahamondes, Martina Hartwig

AU - Merino, Luis Moyano

AU - Pradenas, Ana María

AU - Revillot, Macarena Espinoza

AU - Rodriguez, Patricia

AU - Salinas, Angeles Serrano

AU - Taiba, Carolina

AU - Valdés, Joaquín Farías

AU - Subiabre, Jorge Navarro

AU - Ortega, Carlos

AU - Palma, Sofia

AU - Castillo, Patricia Perez

AU - Pinto, Mónica

AU - Bidegain, Francisco Rivas

AU - Venegas, Margarita

AU - Yucra, Edith

AU - Li, Yang

AU - Cruz, Andres

AU - Guelvez, Beatriz

AU - Victoria Plaza, Regina

AU - Tello Hoyos, Kelly Yoana

AU - Cardoso-Landivar, José

AU - Van Den Boom, Martin

AU - Andréjak, Claire

AU - Blanc, François-Xavier

AU - Dourmane, Samir

AU - Froissart, Antoine

AU - Izadifar, Armine

AU - Rivière, Frédéric

AU - Schlemmer, Frédéric

AU - Manika, Katerina

AU - Diallo, Boubacar Djelo

AU - Hassane-Harouna, Souleymane

AU - Artiles, Norma

AU - Mejia, Licenciada Andrea

AU - Gupta, Nitesh

AU - Ish, Pranav

AU - Mishra, Gyanshankar

AU - Patel, Jigneshkumar M

AU - Singla, Rupak

AU - Udwadia, Zarir F

AU - Alladio, Francesca

AU - Angeli, Fabio

AU - CALCAGNO, Andrea

AU - Centis, Rosella

AU - Codecasa, Luigi Ruffo

AU - De Lauretis, Angelo

AU - Esposito, Susanna M R

AU - Formenti, Beatrice

AU - Gaviraghi, Alberto

AU - Giacomet, Vania

AU - Goletti, Delia

AU - Gualano, Gina

AU - Matteelli, Alberto

AU - Migliori, Giovanni Battista

AU - Motta, Ilaria

AU - Palmieri, Fabrizio

AU - Pontali, Emanuele

AU - Prestileo, Tullio

AU - Riccardi, Niccolò

AU - Saderi, Laura

AU - Saporiti, Matteo

AU - Sotgiu, Giovanni

AU - Spanevello, Antonio

AU - Stochino, Claudia

AU - Tadolini, Marina

AU - Torre, Alessandro

AU - Villa, Simone

AU - Visca, Dina

AU - Kurhasani, Xhevat

AU - Furjani, Mohammed

AU - Rasheed, Najia

AU - Danila, Edvardas

AU - Diktanas, Saulius

AU - Ridaura, Ruy López

AU - Luna López, Fátima Leticia

AU - Torrico, Marcela Muñoz

AU - Rendon, Adrian

AU - Akkerman, Onno W

AU - Chizaram, Onyeaghala

AU - Al-Abri, Seif

AU - Alyaquobi, Fatma

AU - Althohli, Khalsa

AU - Aguirre, Sarita

AU - Teixeira, Rosarito Coronel

AU - De Egea, Viviana

AU - Irala, Sandra

AU - Medina, Angélica

AU - Sequera, Guillermo

AU - Sosa, Natalia

AU - Vázquez, Fátima

AU - Llanos-Tejada, Félix K

AU - Manga, Selene

AU - Villanueva-Villegas, Renzo

AU - Araujo, David

AU - Sales Marques, Raquel DuarteTânia

AU - Socaci, Adriana

AU - Barkanova, Olga

AU - Bogorodskaya, Maria

AU - Borisov, Sergey

AU - Mariandyshev, Andrei

AU - Kaluzhenina, Anna

AU - Vukicevic, Tatjana Adzic

AU - Stosic, Maja

AU - Beh, Darius

AU - Ng, Deborah

AU - Ong, Catherine W M

AU - Solovic, Ivan

AU - Dheda, Keertan

AU - Gina, Phindile

AU - Caminero, José A

AU - De Souza Galvão, Maria Luiza

AU - Dominguez-Castellano, Angel

AU - García-García, José-María

AU - Pinargote, Israel Molina

AU - Fernandez, Sarai Quirós

AU - Sánchez-Montalvá, Adrián

AU - Huguet, Eva Tabernero

AU - Murguiondo, Miguel Zabaleta

AU - Bart, Pierre-Alexandre

AU - Mazza-Stalder, Jesica

AU - D'Ambrosio, Lia

AU - Kamolwat, Phalin

AU - Bakko, Freya

AU - Barnacle, James

AU - Bird, Sophie

AU - Brown, Annabel

AU - Chandran, Shruthi

AU - Killington, Kieran

AU - Man, Kathy

AU - Papineni, Padmasayee

AU - Ritchie, Flora

AU - Tiberi, Simon

AU - Utjesanovic, Natasa

AU - Zenner, Dominik

AU - Hearn, Jasie L

AU - Heysell, Scott

AU - Young, Laura

PY - 2023

Y1 - 2023

N2 - Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods: We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both. Results: Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19 versus those dying because of either TB or COVID-19 alone (p<0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95% CI 1.03-1.07), HIV infection (HR 2.29, 95% CI 1.02-5.16) and invasive ventilation (HR 4.28, 95% CI 2.34-7.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95% CI 1.02-1.04), male sex (HR 2.21, 95% CI 1.24-3.91), oxygen requirement (HR 7.93, 95% CI 3.44-18.26) and invasive ventilation (HR 2.19, 95% CI 1.36-3.53). Conclusions: In our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes.

AB - Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods: We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both. Results: Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19 versus those dying because of either TB or COVID-19 alone (p<0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95% CI 1.03-1.07), HIV infection (HR 2.29, 95% CI 1.02-5.16) and invasive ventilation (HR 4.28, 95% CI 2.34-7.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95% CI 1.02-1.04), male sex (HR 2.21, 95% CI 1.24-3.91), oxygen requirement (HR 7.93, 95% CI 3.44-18.26) and invasive ventilation (HR 2.19, 95% CI 1.36-3.53). Conclusions: In our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes.

UR - https://iris.uniupo.it/handle/11579/216975

U2 - 10.1183/13993003.00925-2023

DO - 10.1183/13993003.00925-2023

M3 - Article

SN - 0903-1936

VL - 62

SP - 1

EP - 12

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 5

ER -

Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort

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