LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

Chiara Fenoglio; Emanuela Oldoni; Maria Serpente; Milena A De Riz; Marina Arcaro; Marianna D'Anca; Anna M Pietroboni; Alberto Calvi; Elisabetta Lecchi; An Goris; Klara Mallants; Bénédicte Dubois; Cristoforo COMI; Roberto Cantello; Elio Scarpini; Daniela Galimberti

doi:10.1016/j.jneuroim.2018.08.008

LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

Chiara Fenoglio, Emanuela Oldoni, Maria Serpente, Milena A De Riz, Marina Arcaro, Marianna D'Anca, Anna M Pietroboni, Alberto Calvi, Elisabetta Lecchi, An Goris, Klara Mallants, Bénédicte Dubois, Cristoforo COMI, Roberto Cantello, Elio Scarpini, Daniela Galimberti

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p ≤ .05 and p ≤ .0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression.

Lingua originale	Inglese
Rivista	Journal of Neuroimmunology
DOI	https://doi.org/10.1016/j.jneuroim.2018.08.008
Stato di pubblicazione	Pubblicato - 2018

Keywords

Biomarker
Gene expression
Multiple Sclerosis
Non coding RNA

Accesso al documento

10.1016/j.jneuroim.2018.08.008

http://hdl.handle.net/11579/97695

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Fenoglio, C., Oldoni, E., Serpente, M., De Riz, M. A., Arcaro, M., D'Anca, M., Pietroboni, A. M., Calvi, A., Lecchi, E., Goris, A., Mallants, K., Dubois, B., COMI, C., Cantello, R., Scarpini, E., & Galimberti, D. (2018). LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients. Journal of Neuroimmunology. https://doi.org/10.1016/j.jneuroim.2018.08.008

@article{6ec80adaa30042fa891d5e4275b61ded,

title = "LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients",

abstract = "LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p ≤ .05 and p ≤ .0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression.",

keywords = "Biomarker, Gene expression, Multiple Sclerosis, Non coding RNA, Biomarker, Gene expression, Multiple Sclerosis, Non coding RNA",

author = "Chiara Fenoglio and Emanuela Oldoni and Maria Serpente and {De Riz}, {Milena A} and Marina Arcaro and Marianna D'Anca and Pietroboni, {Anna M} and Alberto Calvi and Elisabetta Lecchi and An Goris and Klara Mallants and B{\'e}n{\'e}dicte Dubois and Cristoforo COMI and Roberto Cantello and Elio Scarpini and Daniela Galimberti",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

doi = "10.1016/j.jneuroim.2018.08.008",

language = "English",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

}

Fenoglio, C, Oldoni, E, Serpente, M, De Riz, MA, Arcaro, M, D'Anca, M, Pietroboni, AM, Calvi, A, Lecchi, E, Goris, A, Mallants, K, Dubois, B, COMI, C, Cantello, R, Scarpini, E & Galimberti, D 2018, 'LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients', Journal of Neuroimmunology. https://doi.org/10.1016/j.jneuroim.2018.08.008

TY - JOUR

T1 - LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

AU - Fenoglio, Chiara

AU - Oldoni, Emanuela

AU - Serpente, Maria

AU - De Riz, Milena A

AU - Arcaro, Marina

AU - D'Anca, Marianna

AU - Pietroboni, Anna M

AU - Calvi, Alberto

AU - Lecchi, Elisabetta

AU - Goris, An

AU - Mallants, Klara

AU - Dubois, Bénédicte

AU - COMI, Cristoforo

AU - Cantello, Roberto

AU - Scarpini, Elio

AU - Galimberti, Daniela

PY - 2018

Y1 - 2018

N2 - LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p ≤ .05 and p ≤ .0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression.

AB - LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p ≤ .05 and p ≤ .0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression.

KW - Biomarker

KW - Gene expression

KW - Multiple Sclerosis

KW - Non coding RNA

KW - Biomarker

KW - Gene expression

KW - Multiple Sclerosis

KW - Non coding RNA

UR - https://iris.uniupo.it/handle/11579/97695

U2 - 10.1016/j.jneuroim.2018.08.008

DO - 10.1016/j.jneuroim.2018.08.008

M3 - Article

SN - 0165-5728

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

Abstract

Keywords

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