LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

Chiara Fenoglio; Emanuela Oldoni; Maria Serpente; Milena A. De Riz; Marina Arcaro; Marianna D'Anca; Anna M. Pietroboni; Alberto Calvi; Elisabetta Lecchi; An Goris; Klara Mallants; Bénédicte Dubois; Cristoforo Comi; Roberto Cantello; Elio Scarpini; Daniela Galimberti

doi:10.1016/j.jneuroim.2018.08.008

LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

Chiara Fenoglio, Emanuela Oldoni, Maria Serpente, Milena A. De Riz, Marina Arcaro, Marianna D'Anca, Anna M. Pietroboni, Alberto Calvi, Elisabetta Lecchi, An Goris, Klara Mallants, Bénédicte Dubois, Cristoforo Comi, Roberto Cantello, Elio Scarpini, Daniela Galimberti

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p ≤.05 and p ≤.0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression.

Lingua originale	Inglese
pagine (da-a)	129-135
Numero di pagine	7
Rivista	Journal of Neuroimmunology
Volume	324
DOI	https://doi.org/10.1016/j.jneuroim.2018.08.008
Stato di pubblicazione	Pubblicato - 15 nov 2018

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10.1016/j.jneuroim.2018.08.008

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Fenoglio, C., Oldoni, E., Serpente, M., De Riz, M. A., Arcaro, M., D'Anca, M., Pietroboni, A. M., Calvi, A., Lecchi, E., Goris, A., Mallants, K., Dubois, B., Comi, C., Cantello, R., Scarpini, E., & Galimberti, D. (2018). LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients. Journal of Neuroimmunology, 324, 129-135. https://doi.org/10.1016/j.jneuroim.2018.08.008

@article{6ec80adaa30042fa891d5e4275b61ded,

title = "LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients",

abstract = "LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p ≤.05 and p ≤.0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression.",

keywords = "Biomarker, Gene expression, Multiple Sclerosis, Non coding RNA",

author = "Chiara Fenoglio and Emanuela Oldoni and Maria Serpente and {De Riz}, {Milena A.} and Marina Arcaro and Marianna D'Anca and Pietroboni, {Anna M.} and Alberto Calvi and Elisabetta Lecchi and An Goris and Klara Mallants and B{\'e}n{\'e}dicte Dubois and Cristoforo Comi and Roberto Cantello and Elio Scarpini and Daniela Galimberti",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

year = "2018",

month = nov,

day = "15",

doi = "10.1016/j.jneuroim.2018.08.008",

language = "English",

volume = "324",

pages = "129--135",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

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Fenoglio, C, Oldoni, E, Serpente, M, De Riz, MA, Arcaro, M, D'Anca, M, Pietroboni, AM, Calvi, A, Lecchi, E, Goris, A, Mallants, K, Dubois, B, Comi, C, Cantello, R, Scarpini, E & Galimberti, D 2018, 'LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients', Journal of Neuroimmunology, vol. 324, pagg. 129-135. https://doi.org/10.1016/j.jneuroim.2018.08.008

TY - JOUR

T1 - LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

AU - Fenoglio, Chiara

AU - Oldoni, Emanuela

AU - Serpente, Maria

AU - De Riz, Milena A.

AU - Arcaro, Marina

AU - D'Anca, Marianna

AU - Pietroboni, Anna M.

AU - Calvi, Alberto

AU - Lecchi, Elisabetta

AU - Goris, An

AU - Mallants, Klara

AU - Dubois, Bénédicte

AU - Comi, Cristoforo

AU - Cantello, Roberto

AU - Scarpini, Elio

AU - Galimberti, Daniela

PY - 2018/11/15

Y1 - 2018/11/15

N2 - LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p ≤.05 and p ≤.0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression.

AB - LncRNA PCR arrays containing 90 common LncRNAs were used to screen lncRNA expression levels in PBMC from a discovery population of patients with MS. Data from discovery and replications cohorts showed a generalized dysregulation of lncRNA levels in MS patients compared with controls. MALAT1, MEG9, NRON, ANRIL, TUG1, XIST, SOX2OT, GOMAFU, HULC, BACE-1AS were significantly downregulated in MS patients in comparison with controls. Therefore, we performed a validation analysis in an independent cohort of Belgian origin. In this study, NRON and TUG1 downregulations in MS patients compared with controls were confirmed (p ≤.05 and p ≤.0001 respectively), whereas considering the other lncRNAs, the statistical threshold was not reached. LncRNAs profiling could thus represent a new challenge in the research of easy detectable biomarkers of disease susceptibility and progression.

KW - Biomarker

KW - Gene expression

KW - Multiple Sclerosis

KW - Non coding RNA

UR - http://www.scopus.com/inward/record.url?scp=85052756621&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2018.08.008

DO - 10.1016/j.jneuroim.2018.08.008

M3 - Article

SN - 0165-5728

VL - 324

SP - 129

EP - 135

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

Abstract

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