Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles

Giuseppe Ferrauto; Fabio Carniato; Enza Di Gregorio; Lorenzo Tei; Mauro Botta; Silvio Aime

doi:10.1039/c6nr08282c

Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles

Giuseppe Ferrauto, Fabio Carniato, Enza Di Gregorio, Lorenzo Tei, Mauro Botta, Silvio Aime

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Indocyanine green was encapsulated inside the pores of pegylated amino-functionalized MCM-41 Mesoporous Silica Nanoparticles (ICG-MSNs). In addition to a greater stability and a decrease of toxicity, the photoacoustic effect of ICG-MSNs increases by nearly 400% compared to free ICG due to fluorescence quenching and high photothermal conversion of the encapsulated dyes. Upon i.v. administration in tumor-bearing mice, an overall photoacoustic enhancement of ca. 25% was measured in the tumor region.

Lingua originale	Inglese
pagine (da-a)	99-103
Numero di pagine	5
Rivista	Nanoscale
Volume	9
Numero di pubblicazione	1
DOI	https://doi.org/10.1039/c6nr08282c
Stato di pubblicazione	Pubblicato - 7 gen 2017

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10.1039/c6nr08282c

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title = "Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles",

abstract = "Indocyanine green was encapsulated inside the pores of pegylated amino-functionalized MCM-41 Mesoporous Silica Nanoparticles (ICG-MSNs). In addition to a greater stability and a decrease of toxicity, the photoacoustic effect of ICG-MSNs increases by nearly 400% compared to free ICG due to fluorescence quenching and high photothermal conversion of the encapsulated dyes. Upon i.v. administration in tumor-bearing mice, an overall photoacoustic enhancement of ca. 25% was measured in the tumor region.",

author = "Giuseppe Ferrauto and Fabio Carniato and {Di Gregorio}, Enza and Lorenzo Tei and Mauro Botta and Silvio Aime",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

month = jan,

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doi = "10.1039/c6nr08282c",

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T1 - Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles

AU - Ferrauto, Giuseppe

AU - Carniato, Fabio

AU - Di Gregorio, Enza

AU - Tei, Lorenzo

AU - Botta, Mauro

AU - Aime, Silvio

PY - 2017/1/7

Y1 - 2017/1/7

N2 - Indocyanine green was encapsulated inside the pores of pegylated amino-functionalized MCM-41 Mesoporous Silica Nanoparticles (ICG-MSNs). In addition to a greater stability and a decrease of toxicity, the photoacoustic effect of ICG-MSNs increases by nearly 400% compared to free ICG due to fluorescence quenching and high photothermal conversion of the encapsulated dyes. Upon i.v. administration in tumor-bearing mice, an overall photoacoustic enhancement of ca. 25% was measured in the tumor region.

AB - Indocyanine green was encapsulated inside the pores of pegylated amino-functionalized MCM-41 Mesoporous Silica Nanoparticles (ICG-MSNs). In addition to a greater stability and a decrease of toxicity, the photoacoustic effect of ICG-MSNs increases by nearly 400% compared to free ICG due to fluorescence quenching and high photothermal conversion of the encapsulated dyes. Upon i.v. administration in tumor-bearing mice, an overall photoacoustic enhancement of ca. 25% was measured in the tumor region.

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U2 - 10.1039/c6nr08282c

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JO - Nanoscale

JF - Nanoscale

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ER -

Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles

Abstract

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