TY - JOUR
T1 - Laparoscopic Versus Open Caudate Lobe Resection
T2 - A Systematic Review with a Meta-Analysis of Comparative Studies
AU - Cassese, Gianluca
AU - Giannone, Fabio
AU - Del Basso, Celeste
AU - Alagia, Mariantonietta
AU - Lodin, Marco
AU - Monsellato, Igor
AU - Palucci, Marco
AU - Sangiuolo, Federico
AU - Millan, Gabriela Del Angel
AU - Panaro, Fabrizio
N1 - Publisher Copyright:
© 2025 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2025/7/1
Y1 - 2025/7/1
N2 - Background: Liver resection of a caudate lobe is a challenging procedure in both open and minimally invasive approaches. The reason is mainly related to its anatomical position: segment 1 (S1) lies on the inferior vein cava, behind the main and the left portal veins, and below the hepatic veins. This meta-analysis aimed to assess the results of laparoscopic liver resection (LLR) versus open liver resection (OLR) for S1 resection. Methods: Available literature up to June 2024 was retrieved from the Medline and Embase databases. A systematic review with a meta-analysis was carried out to investigate the safety and efficacy of LLR for the S1 segment. Results: Six studies including 292 patients (LLR: n = 132; OLR: n = 160) were selected for the meta-analysis. The OLR cohort showed higher estimated blood loss (EBL) (MD: 140.1, 95% CI 49.3–130.8; p = 0.011) and longer length of hospital stay (MD: 3, 95% CI 1.8–4.2; p = 0.001). No differences in severe postoperative morbidity, overall morbidity, R1 resection rates, transfusion rates, operative time, and duration of Pringle maneuvers were shown. Conclusion: LLR for lesions located in S1 is safe and effective and may be associated with lower EBL and shorter length of stay than OLR. Further larger prospective studies are needed to confirm such results.
AB - Background: Liver resection of a caudate lobe is a challenging procedure in both open and minimally invasive approaches. The reason is mainly related to its anatomical position: segment 1 (S1) lies on the inferior vein cava, behind the main and the left portal veins, and below the hepatic veins. This meta-analysis aimed to assess the results of laparoscopic liver resection (LLR) versus open liver resection (OLR) for S1 resection. Methods: Available literature up to June 2024 was retrieved from the Medline and Embase databases. A systematic review with a meta-analysis was carried out to investigate the safety and efficacy of LLR for the S1 segment. Results: Six studies including 292 patients (LLR: n = 132; OLR: n = 160) were selected for the meta-analysis. The OLR cohort showed higher estimated blood loss (EBL) (MD: 140.1, 95% CI 49.3–130.8; p = 0.011) and longer length of hospital stay (MD: 3, 95% CI 1.8–4.2; p = 0.001). No differences in severe postoperative morbidity, overall morbidity, R1 resection rates, transfusion rates, operative time, and duration of Pringle maneuvers were shown. Conclusion: LLR for lesions located in S1 is safe and effective and may be associated with lower EBL and shorter length of stay than OLR. Further larger prospective studies are needed to confirm such results.
KW - caudate lobe
KW - laparoscopic liver resection
KW - segment one
UR - https://www.scopus.com/pages/publications/105019487685
U2 - 10.3390/JCM14134421
DO - 10.3390/JCM14134421
M3 - Review article
SN - 2077-0383
VL - 14
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 13
M1 - 4421
ER -