Lanthanide(III)complexes with ligands derived from a cyclen framework containing pyridinecarboxylate pendants. the effect of steric hindrance on the hydration number

Two new macrocyclic ligands, 6,6′-((1,4,7,10-tetraazacyclododecane-1, 7-diyl)bis(methylene))dipicolinic acid (H ₂DODPA)and 6,6′-((4,10-dimethyl-1,4,7,10-tetraazacyclododecane-1,7-diyl) bis(methylene))dipicolinic acid (H ₂Me-DODPA), designed for complexation of lanthanide ions in aqueous solution, have been synthesized and studied. The X-ray crystal structure of [Yb(DODPA)](PF ₆) ·H ₂O shows that the metal ion is directly bound to the eight donor atoms of the ligand, which results in a square-antiprismatic coordination around the metal ion. The hydration numbers (q)obtained from luminescence lifetime measurements in aqueous solution of the EuIII and TbIII complexes indicate that the DODPA complexes contain one inner-sphere water molecule, while those of the methylated analogue H ₂Me-DODPA are q = 0. The structure of the complexes in solution has been investigated by 1H and 13C NMR spectroscopy, as well as by theoretical calculations performed at the density functional theory (DFT; mPWB95)level. The minimum energy conformation calculated for the Yb ^III complex [Λ (λ λ λ λ)] is in good agreement with the experimental structure in solution, as demonstrated by the analysis of the Yb ^III-induced paramagnetic 1H shifts. The nuclear magnetic relaxation dispersion (NMRD)profiles recorded for [Gd(Me-DODPA)]+ are typical of a complex with q = 0, where the observed relaxivity can be accounted for by the outer-sphere mechanism. However, [Gd(DODPA)] ⁺ shows NMRD profiles consistent with the presence of both inner-and outer-sphere contributions to relaxivity. A simultaneous fitting of the NMRD profiles and variable temperature 17O NMR chemical shifts and transversal relaxation rates provided the parameters governing the relaxivity in [Gd(DODPA)]+. The results show that this system is endowed with a relatively fast water exchange rate k _ex ²⁹⁸ = 58 × 10 ⁶ s ^-1.