TY - JOUR
T1 - Keratinocytes express dipeptidyl-peptidase IV (CD26) in benign and malignant skin diseases
AU - Novelli, M.
AU - Savoia, P.
AU - Fierro, M. T.
AU - Verrone, A.
AU - Quaglino, P.
AU - Bernengo, M. G.
PY - 1996
Y1 - 1996
N2 - CD26 expression on keratinocytes, in both normal and pathological skin, was investigated using immunohistochemical techniques. A sporadic focal CD26 positivity was found in normal skin, whereas increased expression of CD26 was observed both in cutaneous T-cell lymphomas and in inflammatory skin diseases, e.g. psoriasis, lichen planus and spongiotic dermatitis, in the basal and spinous layers. CD26 keratinocyte staining was not specific for a single disease, but seems to be associated with the presence of a reactive or neoplastic infiltrate in the epidermis. We propose that the CD26 molecule may function as a keratinocyte activation antigen.
AB - CD26 expression on keratinocytes, in both normal and pathological skin, was investigated using immunohistochemical techniques. A sporadic focal CD26 positivity was found in normal skin, whereas increased expression of CD26 was observed both in cutaneous T-cell lymphomas and in inflammatory skin diseases, e.g. psoriasis, lichen planus and spongiotic dermatitis, in the basal and spinous layers. CD26 keratinocyte staining was not specific for a single disease, but seems to be associated with the presence of a reactive or neoplastic infiltrate in the epidermis. We propose that the CD26 molecule may function as a keratinocyte activation antigen.
UR - http://www.scopus.com/inward/record.url?scp=0029934788&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2133.1996.tb07941.x
DO - 10.1111/j.1365-2133.1996.tb07941.x
M3 - Article
SN - 0007-0963
VL - 134
SP - 1052
EP - 1056
JO - British Journal of Dermatology
JF - British Journal of Dermatology
IS - 6
ER -