Italian external and multicentric validation of the MD Anderson Cancer Center nomogram and prognostic index for chronic lymphocytic leukaemia patients: Analysis of 1502 cases

Massimo Gentile, Francesca R. Mauro, Davide Rossi, Iolanda Vincelli, Giovanni Tripepi, Anna G. Recchia, Laura De Stefano, Melissa Campanelli, Diana Giannarelli, Sabrina Bossio, Lucio Morabito, Ernesto Vigna, Gianluca Gaidano, Robin Foà, Fortunato Morabito

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

We performed an external and multicentric validation of the nomogram and prognostic index (PI) proposed by the MD Anderson Cancer Center to prognostically stratify chronic lymphocytic leukaemia (CLL) patients in 1502 CLL cases. All six parameters involved in the nomogram and PI (age, sex, absolute lymphocyte count, number of lymph node groups, Rai stage and β2-microglobulin) were independently associated with survival. The nomogram was accurate in predicting survival (c-index = 0·82). According to the PI, 38·7% of patients were at low-risk, 58·3% at intermediate-risk and 3% at high-risk. The estimated median survival times were: not reached for low-risk, 13·4 years for intermediate-risk and 3·4 years for high-risk. The estimated median and 5-year survival by PI were similar to those originally reported. The PI remained a predictor of survival when analysis was limited to 847 Rai stage 0 (P < 0·0001) and 151 clinical monoclonal B-cell lymphocytosis (cMBL) cases (P = 0·033). Finally, the PI allowed prediction of time to therapy in all patients (P < 0·0001), in Rai 0 (P < 0·0001) and in cMBL cases (P = 0·044). Our results confirm the ability of the PI to predict prognosis, even in early stage disease cases. The study also extended the utility of the PI to cMBL cases.

Lingua originaleInglese
pagine (da-a)224-232
Numero di pagine9
RivistaBritish Journal of Haematology
Volume167
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 1 ott 2014

Fingerprint

Entra nei temi di ricerca di 'Italian external and multicentric validation of the MD Anderson Cancer Center nomogram and prognostic index for chronic lymphocytic leukaemia patients: Analysis of 1502 cases'. Insieme formano una fingerprint unica.

Cita questo