Italian expert-based recommendations on the use of photo(chemo)therapy in the management of mycosis fungoides: Results of an e-Delphi consensus

Vieri Grandi; Antonello Baldo; Emilio Berti; Pietro Quaglino; Serena Rupoli; Mauro Alaibac; Silvia Alberti-Violetti; Paolo Amerio; Valeria Brazzelli; Pier Luigi Bruni; Piergiacomo Calzavara-Pinton; Aurora Parodi; Emanuele Cozzani; Martina Burlando; Maria Concetta Fargnoli; Daniele Gambini; Paolo Iacovelli; Alessia Pacifico; Caterina Longo; Giuseppe Monfrecola; Alberico Motolese; Giorgio Mozzicafreddo; Carlo Cota; Paolo Pigatto; Alessandro Pileri; Paola Savoia; Marco Simonacci; Marina Venturini; Annamaria Offidani; Elisa Molinelli; Michele Pellegrino; Emanuele Trovato; Roberta Piccinno; Karl Lawrence; Nicola Pimpinelli

doi:10.1111/phpp.12658

Italian expert-based recommendations on the use of photo(chemo)therapy in the management of mycosis fungoides: Results of an e-Delphi consensus

Vieri Grandi
, Antonello Baldo
, Emilio Berti
, Pietro Quaglino
, Serena Rupoli
, Mauro Alaibac
, Silvia Alberti-Violetti
, Paolo Amerio
, Valeria Brazzelli
, Pier Luigi Bruni
, Piergiacomo Calzavara-Pinton
, Aurora Parodi
, Emanuele Cozzani
, Martina Burlando
, Maria Concetta Fargnoli
, Daniele Gambini
, Paolo Iacovelli
, Alessia Pacifico
, Caterina Longo
, Giuseppe Monfrecola

Alberico Motolese, Giorgio Mozzicafreddo, Carlo Cota, Paolo Pigatto, Alessandro Pileri, Paola Savoia, Marco Simonacci, Marina Venturini, Annamaria Offidani, Elisa Molinelli, Michele Pellegrino, Emanuele Trovato, Roberta Piccinno, Karl Lawrence, Nicola Pimpinelli

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Background: Phototherapy is a mainstay for the treatment of MF. However, there is scarce evidence for its use, mostly due to the lack of a unified schedule. Aims: The primary aim of this study was to establish the first structured, expert-based consensus regarding the indications and technical schedules of NB-UVB and PUVA for MF. The secondary aim was to determine the consensus level for each specific item. Materials & Methods: E-delphi study. Item-specific expert consensus was defined as the number of “Totally Agree” results to ≥80% of the panelists. Cronbach alpha index ≥0.7 was used as a measure of homogeneity in the responses among questions related to the same topic. Results: Overall, there was a high homogeneity among responders (0.78). On specific topics, the highest grade was observed for technical items (0.8) followed by indications for early (0.73) and advanced stages (0.7). Conclusions: Items related to the most canonical indications of phototherapy and to treatment schedules showed the highest agreements rates. There is consensus about the use of standardized treatment schedules for the induction and consolidation phases for NB-UVB and PUVA in MF.

Lingua originale	Inglese
pagine (da-a)	334-342
Numero di pagine	9
Rivista	Photodermatology Photoimmunology and Photomedicine
Volume	37
Numero di pubblicazione	4
DOI	https://doi.org/10.1111/phpp.12658
Stato di pubblicazione	Pubblicato - lug 2021

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10.1111/phpp.12658

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Grandi, V., Baldo, A., Berti, E., Quaglino, P., Rupoli, S., Alaibac, M., Alberti-Violetti, S., Amerio, P., Brazzelli, V., Bruni, P. L., Calzavara-Pinton, P., Parodi, A., Cozzani, E., Burlando, M., Fargnoli, M. C., Gambini, D., Iacovelli, P., Pacifico, A., Longo, C., ... Pimpinelli, N. (2021). Italian expert-based recommendations on the use of photo(chemo)therapy in the management of mycosis fungoides: Results of an e-Delphi consensus. Photodermatology Photoimmunology and Photomedicine, 37(4), 334-342. https://doi.org/10.1111/phpp.12658

@article{ce58b178885d4f59b0c64a65e664d7c5,

title = "Italian expert-based recommendations on the use of photo(chemo)therapy in the management of mycosis fungoides: Results of an e-Delphi consensus",

abstract = "Background: Phototherapy is a mainstay for the treatment of MF. However, there is scarce evidence for its use, mostly due to the lack of a unified schedule. Aims: The primary aim of this study was to establish the first structured, expert-based consensus regarding the indications and technical schedules of NB-UVB and PUVA for MF. The secondary aim was to determine the consensus level for each specific item. Materials \& Methods: E-delphi study. Item-specific expert consensus was defined as the number of “Totally Agree” results to ≥80\% of the panelists. Cronbach alpha index ≥0.7 was used as a measure of homogeneity in the responses among questions related to the same topic. Results: Overall, there was a high homogeneity among responders (0.78). On specific topics, the highest grade was observed for technical items (0.8) followed by indications for early (0.73) and advanced stages (0.7). Conclusions: Items related to the most canonical indications of phototherapy and to treatment schedules showed the highest agreements rates. There is consensus about the use of standardized treatment schedules for the induction and consolidation phases for NB-UVB and PUVA in MF.",

keywords = "delphi study, evidence-based medicine, guideline, mycosis fungoides, phototherapy",

author = "Vieri Grandi and Antonello Baldo and Emilio Berti and Pietro Quaglino and Serena Rupoli and Mauro Alaibac and Silvia Alberti-Violetti and Paolo Amerio and Valeria Brazzelli and Bruni, \{Pier Luigi\} and Piergiacomo Calzavara-Pinton and Aurora Parodi and Emanuele Cozzani and Martina Burlando and Fargnoli, \{Maria Concetta\} and Daniele Gambini and Paolo Iacovelli and Alessia Pacifico and Caterina Longo and Giuseppe Monfrecola and Alberico Motolese and Giorgio Mozzicafreddo and Carlo Cota and Paolo Pigatto and Alessandro Pileri and Paola Savoia and Marco Simonacci and Marina Venturini and Annamaria Offidani and Elisa Molinelli and Michele Pellegrino and Emanuele Trovato and Roberta Piccinno and Karl Lawrence and Nicola Pimpinelli",

note = "Publisher Copyright: {\textcopyright} 2021 John Wiley \& Sons A/S. Published by John Wiley \& Sons Ltd",

year = "2021",

month = jul,

doi = "10.1111/phpp.12658",

language = "English",

volume = "37",

pages = "334--342",

journal = "Photodermatology Photoimmunology and Photomedicine",

issn = "0905-4383",

publisher = "Blackwell Munksgaard",

number = "4",

}

Grandi, V, Baldo, A, Berti, E, Quaglino, P, Rupoli, S, Alaibac, M, Alberti-Violetti, S, Amerio, P, Brazzelli, V, Bruni, PL, Calzavara-Pinton, P, Parodi, A, Cozzani, E, Burlando, M, Fargnoli, MC, Gambini, D, Iacovelli, P, Pacifico, A, Longo, C, Monfrecola, G, Motolese, A, Mozzicafreddo, G, Cota, C, Pigatto, P, Pileri, A, Savoia, P, Simonacci, M, Venturini, M, Offidani, A, Molinelli, E, Pellegrino, M, Trovato, E, Piccinno, R, Lawrence, K & Pimpinelli, N 2021, 'Italian expert-based recommendations on the use of photo(chemo)therapy in the management of mycosis fungoides: Results of an e-Delphi consensus', Photodermatology Photoimmunology and Photomedicine, vol. 37, n. 4, pagg. 334-342. https://doi.org/10.1111/phpp.12658

Italian expert-based recommendations on the use of photo(chemo)therapy in the management of mycosis fungoides: Results of an e-Delphi consensus. / Grandi, Vieri; Baldo, Antonello; Berti, Emilio et al.
In: Photodermatology Photoimmunology and Photomedicine, Vol. 37, N. 4, 07.2021, pag. 334-342.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Italian expert-based recommendations on the use of photo(chemo)therapy in the management of mycosis fungoides

T2 - Results of an e-Delphi consensus

AU - Grandi, Vieri

AU - Baldo, Antonello

AU - Berti, Emilio

AU - Quaglino, Pietro

AU - Rupoli, Serena

AU - Alaibac, Mauro

AU - Alberti-Violetti, Silvia

AU - Amerio, Paolo

AU - Brazzelli, Valeria

AU - Bruni, Pier Luigi

AU - Calzavara-Pinton, Piergiacomo

AU - Parodi, Aurora

AU - Cozzani, Emanuele

AU - Burlando, Martina

AU - Fargnoli, Maria Concetta

AU - Gambini, Daniele

AU - Iacovelli, Paolo

AU - Pacifico, Alessia

AU - Longo, Caterina

AU - Monfrecola, Giuseppe

AU - Motolese, Alberico

AU - Mozzicafreddo, Giorgio

AU - Cota, Carlo

AU - Pigatto, Paolo

AU - Pileri, Alessandro

AU - Savoia, Paola

AU - Simonacci, Marco

AU - Venturini, Marina

AU - Offidani, Annamaria

AU - Molinelli, Elisa

AU - Pellegrino, Michele

AU - Trovato, Emanuele

AU - Piccinno, Roberta

AU - Lawrence, Karl

AU - Pimpinelli, Nicola

PY - 2021/7

Y1 - 2021/7

N2 - Background: Phototherapy is a mainstay for the treatment of MF. However, there is scarce evidence for its use, mostly due to the lack of a unified schedule. Aims: The primary aim of this study was to establish the first structured, expert-based consensus regarding the indications and technical schedules of NB-UVB and PUVA for MF. The secondary aim was to determine the consensus level for each specific item. Materials & Methods: E-delphi study. Item-specific expert consensus was defined as the number of “Totally Agree” results to ≥80% of the panelists. Cronbach alpha index ≥0.7 was used as a measure of homogeneity in the responses among questions related to the same topic. Results: Overall, there was a high homogeneity among responders (0.78). On specific topics, the highest grade was observed for technical items (0.8) followed by indications for early (0.73) and advanced stages (0.7). Conclusions: Items related to the most canonical indications of phototherapy and to treatment schedules showed the highest agreements rates. There is consensus about the use of standardized treatment schedules for the induction and consolidation phases for NB-UVB and PUVA in MF.

AB - Background: Phototherapy is a mainstay for the treatment of MF. However, there is scarce evidence for its use, mostly due to the lack of a unified schedule. Aims: The primary aim of this study was to establish the first structured, expert-based consensus regarding the indications and technical schedules of NB-UVB and PUVA for MF. The secondary aim was to determine the consensus level for each specific item. Materials & Methods: E-delphi study. Item-specific expert consensus was defined as the number of “Totally Agree” results to ≥80% of the panelists. Cronbach alpha index ≥0.7 was used as a measure of homogeneity in the responses among questions related to the same topic. Results: Overall, there was a high homogeneity among responders (0.78). On specific topics, the highest grade was observed for technical items (0.8) followed by indications for early (0.73) and advanced stages (0.7). Conclusions: Items related to the most canonical indications of phototherapy and to treatment schedules showed the highest agreements rates. There is consensus about the use of standardized treatment schedules for the induction and consolidation phases for NB-UVB and PUVA in MF.

KW - delphi study

KW - evidence-based medicine

KW - guideline

KW - mycosis fungoides

KW - phototherapy

U2 - 10.1111/phpp.12658

DO - 10.1111/phpp.12658

M3 - Article

SN - 0905-4383

VL - 37

SP - 334

EP - 342

JO - Photodermatology Photoimmunology and Photomedicine

JF - Photodermatology Photoimmunology and Photomedicine

IS - 4

ER -

Italian expert-based recommendations on the use of photo(chemo)therapy in the management of mycosis fungoides: Results of an e-Delphi consensus

Abstract

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