@inbook{d13d172b47f14daf93e0e02f7d8ce1f9,
title = "Investigation of the Click-Chemical Space for Drug Design Using ZINClick",
abstract = "This chapter provides a brief overview of the applications of ZINClick virtual library. In the last years, we have investigated the click-chemical space covered by molecules containing the triazole ring and generated a database of 1,2,3-triazoles called ZINClick, starting from literature reported alkynes and azides synthesizable in no more than three synthetic steps from commercially available products. This combinatorial database contains millions of 1,4-disubstituted 1,2,3-triazoles that are easily synthesizable. The library is regularly updated and can be freely downloaded from http://www.ZINClick.org. This virtual library is a good starting point to explore a new portion of chemical space.",
keywords = "Chemical space, Chemoinformatics, Diversity, Library design, Similarity, Virtual screening",
author = "Alberto Massarotti",
note = "Publisher Copyright: {\textcopyright} 2021, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2021",
doi = "10.1007/978-1-0716-1209-5_1",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "3--10",
booktitle = "Methods in Molecular Biology",
}