Inverse correlation of genetic risk score with age at onset in bout-onset and progressiveonset multiple sclerosis

Melissa Sorosina; Federica Esposito; Clara Guaschino; Ferdinando Clarelli; Nadia Barizzone; Ana Maria Osiceanu; Paola Brambilla; Elisabetta Mascia; Paola Cavalla; Paolo Gallo; Vittorio Martinelli; Maurizio Leone; Giancarlo Comi; Sandra D'Alfonso; Filippo Martinelli Boneschi

doi:10.1177/1352458514561910

Inverse correlation of genetic risk score with age at onset in bout-onset and progressiveonset multiple sclerosis

Melissa Sorosina
, Federica Esposito
, Clara Guaschino
, Ferdinando Clarelli
, Nadia Barizzone
, Ana Maria Osiceanu
, Paola Brambilla
, Elisabetta Mascia
, Paola Cavalla
, Paolo Gallo
, Vittorio Martinelli
, Maurizio Leone
, Giancarlo Comi
, Sandra D'Alfonso
, Filippo Martinelli Boneschi

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We correlated the weighted genetic risk score measured using 107 established susceptibility variants for multiple sclerosis (MS) with the age at onset in bout-onset (BOMS, n=906) and progressive-onset MS Italian patients (PrMS) (n=544). We observed an opposite relationship in the two disease courses: a higher weighted genetic risk score was associated with an earlier age at onset in BOMS (rho= -0.1; p=5 × 10^-3) and a later age at onset in PrMS cases (rho=0.07; p=0.15) (p of difference of regres-sion=1.4 × 10^-2). These findings suggest that established MS risk variants anticipate the onset of the inflammatory phase, while they have no impact on, or even delay, the onset of the progressive phase.

Lingua originale	Inglese
pagine (da-a)	1463-1467
Numero di pagine	5
Rivista	Multiple Sclerosis Journal
Volume	21
Numero di pubblicazione	11
DOI	https://doi.org/10.1177/1352458514561910
Stato di pubblicazione	Pubblicato - ott 2015
Pubblicato esternamente	Sì

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10.1177/1352458514561910

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Sorosina, M., Esposito, F., Guaschino, C., Clarelli, F., Barizzone, N., Osiceanu, A. M., Brambilla, P., Mascia, E., Cavalla, P., Gallo, P., Martinelli, V., Leone, M., Comi, G., D'Alfonso, S., & Boneschi, F. M. (2015). Inverse correlation of genetic risk score with age at onset in bout-onset and progressiveonset multiple sclerosis. Multiple Sclerosis Journal, 21(11), 1463-1467. https://doi.org/10.1177/1352458514561910

@article{742a9e6c473343b2ad6d2e6a3f24d2cb,

title = "Inverse correlation of genetic risk score with age at onset in bout-onset and progressiveonset multiple sclerosis",

abstract = "We correlated the weighted genetic risk score measured using 107 established susceptibility variants for multiple sclerosis (MS) with the age at onset in bout-onset (BOMS, n=906) and progressive-onset MS Italian patients (PrMS) (n=544). We observed an opposite relationship in the two disease courses: a higher weighted genetic risk score was associated with an earlier age at onset in BOMS (rho= -0.1; p=5 × 10-3) and a later age at onset in PrMS cases (rho=0.07; p=0.15) (p of difference of regres-sion=1.4 × 10-2). These findings suggest that established MS risk variants anticipate the onset of the inflammatory phase, while they have no impact on, or even delay, the onset of the progressive phase.",

keywords = "Age of onset, Genetic risk, Multiple sclerosis, Primary-progressive, Relapsing-remitting, Weighted genetic risk score",

author = "Melissa Sorosina and Federica Esposito and Clara Guaschino and Ferdinando Clarelli and Nadia Barizzone and Osiceanu, \{Ana Maria\} and Paola Brambilla and Elisabetta Mascia and Paola Cavalla and Paolo Gallo and Vittorio Martinelli and Maurizio Leone and Giancarlo Comi and Sandra D'Alfonso and Boneschi, \{Filippo Martinelli\}",

note = "Publisher Copyright: {\textcopyright} The Author(s), 2014.",

year = "2015",

month = oct,

doi = "10.1177/1352458514561910",

language = "English",

volume = "21",

pages = "1463--1467",

journal = "Multiple Sclerosis Journal",

issn = "1352-4585",

publisher = "SAGE Publications Ltd",

number = "11",

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Sorosina, M, Esposito, F, Guaschino, C, Clarelli, F, Barizzone, N, Osiceanu, AM, Brambilla, P, Mascia, E, Cavalla, P, Gallo, P, Martinelli, V, Leone, M, Comi, G, D'Alfonso, S & Boneschi, FM 2015, 'Inverse correlation of genetic risk score with age at onset in bout-onset and progressiveonset multiple sclerosis', Multiple Sclerosis Journal, vol. 21, n. 11, pagg. 1463-1467. https://doi.org/10.1177/1352458514561910

TY - JOUR

T1 - Inverse correlation of genetic risk score with age at onset in bout-onset and progressiveonset multiple sclerosis

AU - Sorosina, Melissa

AU - Esposito, Federica

AU - Guaschino, Clara

AU - Clarelli, Ferdinando

AU - Barizzone, Nadia

AU - Osiceanu, Ana Maria

AU - Brambilla, Paola

AU - Mascia, Elisabetta

AU - Cavalla, Paola

AU - Gallo, Paolo

AU - Martinelli, Vittorio

AU - Leone, Maurizio

AU - Comi, Giancarlo

AU - D'Alfonso, Sandra

AU - Boneschi, Filippo Martinelli

PY - 2015/10

Y1 - 2015/10

N2 - We correlated the weighted genetic risk score measured using 107 established susceptibility variants for multiple sclerosis (MS) with the age at onset in bout-onset (BOMS, n=906) and progressive-onset MS Italian patients (PrMS) (n=544). We observed an opposite relationship in the two disease courses: a higher weighted genetic risk score was associated with an earlier age at onset in BOMS (rho= -0.1; p=5 × 10-3) and a later age at onset in PrMS cases (rho=0.07; p=0.15) (p of difference of regres-sion=1.4 × 10-2). These findings suggest that established MS risk variants anticipate the onset of the inflammatory phase, while they have no impact on, or even delay, the onset of the progressive phase.

AB - We correlated the weighted genetic risk score measured using 107 established susceptibility variants for multiple sclerosis (MS) with the age at onset in bout-onset (BOMS, n=906) and progressive-onset MS Italian patients (PrMS) (n=544). We observed an opposite relationship in the two disease courses: a higher weighted genetic risk score was associated with an earlier age at onset in BOMS (rho= -0.1; p=5 × 10-3) and a later age at onset in PrMS cases (rho=0.07; p=0.15) (p of difference of regres-sion=1.4 × 10-2). These findings suggest that established MS risk variants anticipate the onset of the inflammatory phase, while they have no impact on, or even delay, the onset of the progressive phase.

KW - Age of onset

KW - Genetic risk

KW - Multiple sclerosis

KW - Primary-progressive

KW - Relapsing-remitting

KW - Weighted genetic risk score

UR - https://www.scopus.com/pages/publications/84985920199

U2 - 10.1177/1352458514561910

DO - 10.1177/1352458514561910

M3 - Article

SN - 1352-4585

VL - 21

SP - 1463

EP - 1467

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 11

ER -

Inverse correlation of genetic risk score with age at onset in bout-onset and progressiveonset multiple sclerosis

Abstract

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