Abstract
Induction of differentiation in murine erythroleukemia cells (MELCs) involves a protein kinase C (PKC)-mediated step. Vincristine-resistant cells respond more rapidly to hybrid polar/apolar inducers than the parental cells. These vineristine-resistant MELCs contain elevated levels of the β isozyme of PKC (PKC-β). Exogenous homologous murine PKC-β, incorporated into permeabilized MELCs, accelerates induced differentiation. Neither rat PKC-β, nor mouse PKC-α, rat PKC-α, incorporated into permeabilized MELCs, is effective in altering the kinetics of induced differentiation. This provides direct evidence for a rate-limiting role for this PKC isozyme during N′,N′-hexamethylenebisacetamide-mediated induced differentiation of a transformed cell.
Lingua originale | Inglese |
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pagine (da-a) | 4417-4420 |
Numero di pagine | 4 |
Rivista | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 87 |
Numero di pubblicazione | 12 |
DOI | |
Stato di pubblicazione | Pubblicato - 1990 |
Pubblicato esternamente | Sì |