Introduction of the β isozyme of protein kinase C accelerates induced differentiation of murine erythroleukemia cells

Edon Melloni, Sandro Pontremoli, Bianca Sparatore, Mauro Patrone, Francesco Grossi, Paul A. Marks, Richard A. Rifkind

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Induction of differentiation in murine erythroleukemia cells (MELCs) involves a protein kinase C (PKC)-mediated step. Vincristine-resistant cells respond more rapidly to hybrid polar/apolar inducers than the parental cells. These vineristine-resistant MELCs contain elevated levels of the β isozyme of PKC (PKC-β). Exogenous homologous murine PKC-β, incorporated into permeabilized MELCs, accelerates induced differentiation. Neither rat PKC-β, nor mouse PKC-α, rat PKC-α, incorporated into permeabilized MELCs, is effective in altering the kinetics of induced differentiation. This provides direct evidence for a rate-limiting role for this PKC isozyme during N′,N′-hexamethylenebisacetamide-mediated induced differentiation of a transformed cell.

Lingua originaleInglese
pagine (da-a)4417-4420
Numero di pagine4
RivistaProceedings of the National Academy of Sciences of the United States of America
Volume87
Numero di pubblicazione12
DOI
Stato di pubblicazionePubblicato - 1990
Pubblicato esternamente

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