Intravascular lymphoma: from vessels to genes

In this issue of Blood, Shimada et al explore the molecular pathogenesis of intravascular large B-cell lymphoma (IVLBCL) and document frequent alterations of immune checkpoint-related genes that favor immune evasion. The authors identified aberrations of PD-L1, PD-L2, and other genes in plasma DNA. These findings open new opportunities for diagnosing and monitoring IVLBCL.(1)