Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?

N. Atassi; E. Beghi; M. Blanquer; N. M. Boulis; Roberto CANTELLO; C. Caponnetto; A. Chiò; S. B. Dunnett; E. L. Feldman; A. Vescovi; LETIZIA MAZZINI; C. Bendotti; Enrica BERSANO; S. Brajkovic; P. Car; Fabiola DE MARCHI; R. Fantozzi; Antonia FOLLENZI; M. Gelati; C. Giorgi; Mariagrazia GRILLI; P. Guenzi; V. La Bella; G. L. Mancardi; G. Panzarasa; M. Poloni; D. Profico; V. Silani; G. Sorarù; R. Spataro; ALESSANDRO STECCO; A. Vercelli

doi:10.1016/j.jcyt.2016.08.005

Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?

N. Atassi, E. Beghi, M. Blanquer, N. M. Boulis, Roberto CANTELLO, C. Caponnetto, A. Chiò, S. B. Dunnett, E. L. Feldman, A. Vescovi, LETIZIA MAZZINI, C. Bendotti, Enrica BERSANO, S. Brajkovic, P. Car, Fabiola DE MARCHI, R. Fantozzi, Antonia FOLLENZI, M. Gelati, C. GiorgiMariagrazia GRILLI, P. Guenzi, V. La Bella, G. L. Mancardi, G. Panzarasa, M. Poloni, D. Profico, V. Silani, G. Sorarù, R. Spataro, ALESSANDRO STECCO, A. Vercelli

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Intraspinal stem cell (SC) transplantation represents a new therapeutic approach for amyotrophic lateral sclerosis (ALS) clinical trials. There are considerable difficulties in designing future efficacy trials, some related to the field of ALS and some that are specific to SCs or the mode of delivery. In October 2015, the most controversial points on SC transplantation were addressed during an international workshop intended to bring together international SC and ALS researchers in a public discussion on a topic for which expertise is limited. During the meeting, a discussion was started on the basic structure of the ideal clinical trial testing the efficacy and safety of SC transplantation. The current document includes a number of consensus points reflecting the design of phase II/III clinical trials.

Lingua originale	Inglese
pagine (da-a)	1471-1475
Numero di pagine	5
Rivista	Cytotherapy
Volume	18
Numero di pubblicazione	12
DOI	https://doi.org/10.1016/j.jcyt.2016.08.005
Stato di pubblicazione	Pubblicato - 2016

Keywords

ALS
clinical trials
stem cells
transplantation

Accesso al documento

10.1016/j.jcyt.2016.08.005

http://hdl.handle.net/11579/83456

Altri file e collegamenti

handle

Cita questo

Atassi, N., Beghi, E., Blanquer, M., Boulis, N. M., CANTELLO, R., Caponnetto, C., Chiò, A., Dunnett, S. B., Feldman, E. L., Vescovi, A., MAZZINI, LETIZIA., Bendotti, C., BERSANO, E., Brajkovic, S., Car, P., DE MARCHI, F., Fantozzi, R., FOLLENZI, A., Gelati, M., ... Vercelli, A. (2016). Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials? Cytotherapy, 18(12), 1471-1475. https://doi.org/10.1016/j.jcyt.2016.08.005

@article{14b3cd9428b14750844fbef70ac31713,

title = "Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?",

abstract = "Intraspinal stem cell (SC) transplantation represents a new therapeutic approach for amyotrophic lateral sclerosis (ALS) clinical trials. There are considerable difficulties in designing future efficacy trials, some related to the field of ALS and some that are specific to SCs or the mode of delivery. In October 2015, the most controversial points on SC transplantation were addressed during an international workshop intended to bring together international SC and ALS researchers in a public discussion on a topic for which expertise is limited. During the meeting, a discussion was started on the basic structure of the ideal clinical trial testing the efficacy and safety of SC transplantation. The current document includes a number of consensus points reflecting the design of phase II/III clinical trials.",

keywords = "ALS, clinical trials, stem cells, transplantation, ALS, clinical trials, stem cells, transplantation",

author = "N. Atassi and E. Beghi and M. Blanquer and Boulis, {N. M.} and Roberto CANTELLO and C. Caponnetto and A. Chi{\`o} and Dunnett, {S. B.} and Feldman, {E. L.} and A. Vescovi and LETIZIA MAZZINI and C. Bendotti and Enrica BERSANO and S. Brajkovic and P. Car and {DE MARCHI}, Fabiola and R. Fantozzi and Antonia FOLLENZI and M. Gelati and C. Giorgi and Mariagrazia GRILLI and P. Guenzi and {La Bella}, V. and Mancardi, {G. L.} and G. Panzarasa and M. Poloni and D. Profico and V. Silani and G. Sorar{\`u} and R. Spataro and ALESSANDRO STECCO and A. Vercelli",

year = "2016",

doi = "10.1016/j.jcyt.2016.08.005",

language = "English",

volume = "18",

pages = "1471--1475",

journal = "Cytotherapy",

issn = "1465-3249",

publisher = "Elsevier B.V.",