Interferon-γ plays a crucial role in T lymphocyte reaction against alloantigens

Santo Landolfo; Franca Cofano; Mirella Giovarelli; Maria Prat; Giorgio Cavallo; Guido Forni

doi:10.1007/BF03029144

Interferon-γ plays a crucial role in T lymphocyte reaction against alloantigens

Santo Landolfo, Franca Cofano, Mirella Giovarelli, Maria Prat, Giorgio Cavallo, Guido Forni

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

In this study we report that addition to mixed lymphocyte reactions of monoclonal antibodies to interferon-γ inhibits alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity is not confined to in vitro models, since daily local injection of these antibodies in CBA/J mice blocks the rejection of fully allogeneic tumor cells consistently displayed by untreated CBA/J mcie.

Lingua originale	Inglese
pagine (da-a)	307-314
Numero di pagine	8
Rivista	La Ricerca in Clinica e in Laboratorio
Volume	15
Numero di pubblicazione	4
DOI	https://doi.org/10.1007/BF03029144
Stato di pubblicazione	Pubblicato - ott 1985
Pubblicato esternamente	Sì

Accesso al documento

10.1007/BF03029144

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{e7fb8c2856924a2884bfd5a03435d11c,

title = "Interferon-γ plays a crucial role in T lymphocyte reaction against alloantigens",

abstract = "In this study we report that addition to mixed lymphocyte reactions of monoclonal antibodies to interferon-γ inhibits alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity is not confined to in vitro models, since daily local injection of these antibodies in CBA/J mice blocks the rejection of fully allogeneic tumor cells consistently displayed by untreated CBA/J mcie.",

keywords = "Allograft rejection, Mixed lymphocyte reaction, Monoclonal antibodies, Murine interferon-γ, T lymphocytes, Tumors",

author = "Santo Landolfo and Franca Cofano and Mirella Giovarelli and Maria Prat and Giorgio Cavallo and Guido Forni",

year = "1985",

month = oct,

doi = "10.1007/BF03029144",

language = "English",

volume = "15",

pages = "307--314",

journal = "La Ricerca in Clinica e in Laboratorio",

issn = "0390-5748",

number = "4",

}

TY - JOUR

T1 - Interferon-γ plays a crucial role in T lymphocyte reaction against alloantigens

AU - Landolfo, Santo

AU - Cofano, Franca

AU - Giovarelli, Mirella

AU - Prat, Maria

AU - Cavallo, Giorgio

AU - Forni, Guido

PY - 1985/10

Y1 - 1985/10

N2 - In this study we report that addition to mixed lymphocyte reactions of monoclonal antibodies to interferon-γ inhibits alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity is not confined to in vitro models, since daily local injection of these antibodies in CBA/J mice blocks the rejection of fully allogeneic tumor cells consistently displayed by untreated CBA/J mcie.

AB - In this study we report that addition to mixed lymphocyte reactions of monoclonal antibodies to interferon-γ inhibits alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity is not confined to in vitro models, since daily local injection of these antibodies in CBA/J mice blocks the rejection of fully allogeneic tumor cells consistently displayed by untreated CBA/J mcie.

KW - Allograft rejection

KW - Mixed lymphocyte reaction

KW - Monoclonal antibodies

KW - Murine interferon-γ

KW - T lymphocytes

KW - Tumors

UR - http://www.scopus.com/inward/record.url?scp=0022143457&partnerID=8YFLogxK

U2 - 10.1007/BF03029144

DO - 10.1007/BF03029144

M3 - Article

SN - 0390-5748

VL - 15

SP - 307

EP - 314

JO - La Ricerca in Clinica e in Laboratorio

JF - La Ricerca in Clinica e in Laboratorio

IS - 4

ER -

Interferon-γ plays a crucial role in T lymphocyte reaction against alloantigens

Abstract

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo