Interaction of macrocyclic gadolinium-based MR contrast agents with Type i collagen. Equilibrium and kinetic studies

Nicol Guidolin; Fabio Travagin; Giovanni B. Giovenzana; Adrienn Vágner; Sophia Lotti; Federica Chianale; Ernő Brücher; Federico Maisano; Miles A. Kirchin; Fabio Tedoldi; Alice Giorgini; Sonia Colombo Serra; Zsolt Baranyai

doi:10.1039/d0dt03314f

Interaction of macrocyclic gadolinium-based MR contrast agents with Type i collagen. Equilibrium and kinetic studies

Nicol Guidolin
, Fabio Travagin
, Giovanni B. Giovenzana
, Adrienn Vágner
, Sophia Lotti
, Federica Chianale
, Ernő Brücher
, Federico Maisano
, Miles A. Kirchin
, Fabio Tedoldi
, Alice Giorgini
, Sonia Colombo Serra
, Zsolt Baranyai

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The interactions of gadoterate meglumine, gadobutrol, gadoteridol and Gd(HB-DO3A) with bovine Type I collagen were investigated by ultrafiltration and dialysis. The affinity of the four agents to collagen is similar. However, the maximum adsorbed amount of GdIII-complexes decreases in the following order: gadoterate meglumine > gadobutrol > gadoteridol > Gd(HB-DO3A). Calculations with the open three-compartment model reveal that the structural homologs gadoteridol and Gd(HB-DO3A) have a lower adsorption onto collagen, which may explain the less prolonged in vivo retention of gadoteridol observed in soft tissues of rats.

Lingua originale	Inglese
pagine (da-a)	14863-14870
Numero di pagine	8
Rivista	Dalton Transactions
Volume	49
Numero di pubblicazione	42
DOI	https://doi.org/10.1039/d0dt03314f
Stato di pubblicazione	Pubblicato - 14 nov 2020

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10.1039/d0dt03314f

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Guidolin, N., Travagin, F., Giovenzana, G. B., Vágner, A., Lotti, S., Chianale, F., Brücher, E., Maisano, F., Kirchin, M. A., Tedoldi, F., Giorgini, A., Colombo Serra, S., & Baranyai, Z. (2020). Interaction of macrocyclic gadolinium-based MR contrast agents with Type i collagen. Equilibrium and kinetic studies. Dalton Transactions, 49(42), 14863-14870. https://doi.org/10.1039/d0dt03314f

@article{d9f6e7ed69da40c28e0a3566d3d49934,

title = "Interaction of macrocyclic gadolinium-based MR contrast agents with Type i collagen. Equilibrium and kinetic studies",

abstract = "The interactions of gadoterate meglumine, gadobutrol, gadoteridol and Gd(HB-DO3A) with bovine Type I collagen were investigated by ultrafiltration and dialysis. The affinity of the four agents to collagen is similar. However, the maximum adsorbed amount of GdIII-complexes decreases in the following order: gadoterate meglumine > gadobutrol > gadoteridol > Gd(HB-DO3A). Calculations with the open three-compartment model reveal that the structural homologs gadoteridol and Gd(HB-DO3A) have a lower adsorption onto collagen, which may explain the less prolonged in vivo retention of gadoteridol observed in soft tissues of rats.",

author = "Nicol Guidolin and Fabio Travagin and Giovenzana, \{Giovanni B.\} and Adrienn V{\'a}gner and Sophia Lotti and Federica Chianale and Ern{\H o} Br{\"u}cher and Federico Maisano and Kirchin, \{Miles A.\} and Fabio Tedoldi and Alice Giorgini and \{Colombo Serra\}, Sonia and Zsolt Baranyai",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2020",

month = nov,

day = "14",

doi = "10.1039/d0dt03314f",

language = "English",

volume = "49",

pages = "14863--14870",

journal = "Dalton Transactions",

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publisher = "Royal Society of Chemistry",

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Guidolin, N, Travagin, F, Giovenzana, GB, Vágner, A, Lotti, S, Chianale, F, Brücher, E, Maisano, F, Kirchin, MA, Tedoldi, F, Giorgini, A, Colombo Serra, S & Baranyai, Z 2020, 'Interaction of macrocyclic gadolinium-based MR contrast agents with Type i collagen. Equilibrium and kinetic studies', Dalton Transactions, vol. 49, n. 42, pagg. 14863-14870. https://doi.org/10.1039/d0dt03314f

TY - JOUR

T1 - Interaction of macrocyclic gadolinium-based MR contrast agents with Type i collagen. Equilibrium and kinetic studies

AU - Guidolin, Nicol

AU - Travagin, Fabio

AU - Giovenzana, Giovanni B.

AU - Vágner, Adrienn

AU - Lotti, Sophia

AU - Chianale, Federica

AU - Brücher, Ernő

AU - Maisano, Federico

AU - Kirchin, Miles A.

AU - Tedoldi, Fabio

AU - Giorgini, Alice

AU - Colombo Serra, Sonia

AU - Baranyai, Zsolt

PY - 2020/11/14

Y1 - 2020/11/14

N2 - The interactions of gadoterate meglumine, gadobutrol, gadoteridol and Gd(HB-DO3A) with bovine Type I collagen were investigated by ultrafiltration and dialysis. The affinity of the four agents to collagen is similar. However, the maximum adsorbed amount of GdIII-complexes decreases in the following order: gadoterate meglumine > gadobutrol > gadoteridol > Gd(HB-DO3A). Calculations with the open three-compartment model reveal that the structural homologs gadoteridol and Gd(HB-DO3A) have a lower adsorption onto collagen, which may explain the less prolonged in vivo retention of gadoteridol observed in soft tissues of rats.

AB - The interactions of gadoterate meglumine, gadobutrol, gadoteridol and Gd(HB-DO3A) with bovine Type I collagen were investigated by ultrafiltration and dialysis. The affinity of the four agents to collagen is similar. However, the maximum adsorbed amount of GdIII-complexes decreases in the following order: gadoterate meglumine > gadobutrol > gadoteridol > Gd(HB-DO3A). Calculations with the open three-compartment model reveal that the structural homologs gadoteridol and Gd(HB-DO3A) have a lower adsorption onto collagen, which may explain the less prolonged in vivo retention of gadoteridol observed in soft tissues of rats.

UR - https://www.scopus.com/pages/publications/85095460950

U2 - 10.1039/d0dt03314f

DO - 10.1039/d0dt03314f

M3 - Article

SN - 1477-9226

VL - 49

SP - 14863

EP - 14870

JO - Dalton Transactions

JF - Dalton Transactions

IS - 42

ER -

Interaction of macrocyclic gadolinium-based MR contrast agents with Type i collagen. Equilibrium and kinetic studies

Abstract

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