Abstract
The interactions of gadoterate meglumine, gadobutrol, gadoteridol and Gd(HB-DO3A) with bovine Type I collagen were investigated by ultrafiltration and dialysis. The affinity of the four agents to collagen is similar. However, the maximum adsorbed amount of GdIII-complexes decreases in the following order: gadoterate meglumine > gadobutrol > gadoteridol > Gd(HB-DO3A). Calculations with the open three-compartment model reveal that the structural homologs gadoteridol and Gd(HB-DO3A) have a lower adsorption onto collagen, which may explain the less prolonged in vivo retention of gadoteridol observed in soft tissues of rats.
Lingua originale | Inglese |
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pagine (da-a) | 14863-14870 |
Numero di pagine | 8 |
Rivista | Dalton Transactions |
Volume | 49 |
Numero di pubblicazione | 42 |
DOI | |
Stato di pubblicazione | Pubblicato - 14 nov 2020 |