Interaction of macrocyclic gadolinium-based MR contrast agents with Type i collagen. Equilibrium and kinetic studies

Nicol Guidolin, Fabio Travagin, Giovanni B. Giovenzana, Adrienn Vágner, Sophia Lotti, Federica Chianale, Ernő Brücher, Federico Maisano, Miles A. Kirchin, Fabio Tedoldi, Alice Giorgini, Sonia Colombo Serra, Zsolt Baranyai

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The interactions of gadoterate meglumine, gadobutrol, gadoteridol and Gd(HB-DO3A) with bovine Type I collagen were investigated by ultrafiltration and dialysis. The affinity of the four agents to collagen is similar. However, the maximum adsorbed amount of GdIII-complexes decreases in the following order: gadoterate meglumine > gadobutrol > gadoteridol > Gd(HB-DO3A). Calculations with the open three-compartment model reveal that the structural homologs gadoteridol and Gd(HB-DO3A) have a lower adsorption onto collagen, which may explain the less prolonged in vivo retention of gadoteridol observed in soft tissues of rats.

Lingua originaleInglese
pagine (da-a)14863-14870
Numero di pagine8
RivistaDalton Transactions
Volume49
Numero di pubblicazione42
DOI
Stato di pubblicazionePubblicato - 14 nov 2020

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