Integrated profiling of diffuse large B-cell lymphoma with 7q gain

Ekaterina Chigrinova; Michael Mian; Yulei Shen; Timothy C. Greiner; Wing C. Chan; Julie M. Vose; Giorgio Inghirami; Annalisa Chiappella; Luca Baldini; Maurilio Ponzoni; Andrés J.M. Ferreri; Silvia Franceschetti; Gianluca Gaidano; Alessandra Tucci; Fabio Facchetti; Thierry Lazure; Olivier Lambotte; Santiago Montes-Moreno; Miguel A. Piris; Emanuele Zucca; Ivo Kwee; Francesco Bertoni

doi:10.1111/j.1365-2141.2011.08628.x

Integrated profiling of diffuse large B-cell lymphoma with 7q gain

Ekaterina Chigrinova, Michael Mian, Yulei Shen, Timothy C. Greiner, Wing C. Chan, Julie M. Vose, Giorgio Inghirami, Annalisa Chiappella, Luca Baldini, Maurilio Ponzoni, Andrés J.M. Ferreri, Silvia Franceschetti, Gianluca Gaidano, Alessandra Tucci, Fabio Facchetti, Thierry Lazure, Olivier Lambotte, Santiago Montes-Moreno, Miguel A. Piris, Emanuele ZuccaIvo Kwee, Francesco Bertoni

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.

Lingua originale	Inglese
pagine (da-a)	499-503
Numero di pagine	5
Rivista	British Journal of Haematology
Volume	153
Numero di pubblicazione	4
DOI	https://doi.org/10.1111/j.1365-2141.2011.08628.x
Stato di pubblicazione	Pubblicato - mag 2011

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10.1111/j.1365-2141.2011.08628.x

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Chigrinova, E., Mian, M., Shen, Y., Greiner, T. C., Chan, W. C., Vose, J. M., Inghirami, G., Chiappella, A., Baldini, L., Ponzoni, M., Ferreri, A. J. M., Franceschetti, S., Gaidano, G., Tucci, A., Facchetti, F., Lazure, T., Lambotte, O., Montes-Moreno, S., Piris, M. A., ... Bertoni, F. (2011). Integrated profiling of diffuse large B-cell lymphoma with 7q gain. British Journal of Haematology, 153(4), 499-503. https://doi.org/10.1111/j.1365-2141.2011.08628.x

@article{1f831d98e82747e48dee55f38cc0a606,

title = "Integrated profiling of diffuse large B-cell lymphoma with 7q gain",

abstract = "To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.",

keywords = "Affymetrix, Aggressive lymphoma, Bone marrow, Gain, MiRNA",

author = "Ekaterina Chigrinova and Michael Mian and Yulei Shen and Greiner, {Timothy C.} and Chan, {Wing C.} and Vose, {Julie M.} and Giorgio Inghirami and Annalisa Chiappella and Luca Baldini and Maurilio Ponzoni and Ferreri, {Andr{\'e}s J.M.} and Silvia Franceschetti and Gianluca Gaidano and Alessandra Tucci and Fabio Facchetti and Thierry Lazure and Olivier Lambotte and Santiago Montes-Moreno and Piris, {Miguel A.} and Emanuele Zucca and Ivo Kwee and Francesco Bertoni",

year = "2011",

month = may,

doi = "10.1111/j.1365-2141.2011.08628.x",

language = "English",

volume = "153",

pages = "499--503",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

Chigrinova, E, Mian, M, Shen, Y, Greiner, TC, Chan, WC, Vose, JM, Inghirami, G, Chiappella, A, Baldini, L, Ponzoni, M, Ferreri, AJM, Franceschetti, S, Gaidano, G, Tucci, A, Facchetti, F, Lazure, T, Lambotte, O, Montes-Moreno, S, Piris, MA, Zucca, E, Kwee, I & Bertoni, F 2011, 'Integrated profiling of diffuse large B-cell lymphoma with 7q gain', British Journal of Haematology, vol. 153, n. 4, pagg. 499-503. https://doi.org/10.1111/j.1365-2141.2011.08628.x

TY - JOUR

T1 - Integrated profiling of diffuse large B-cell lymphoma with 7q gain

AU - Chigrinova, Ekaterina

AU - Mian, Michael

AU - Shen, Yulei

AU - Greiner, Timothy C.

AU - Chan, Wing C.

AU - Vose, Julie M.

AU - Inghirami, Giorgio

AU - Chiappella, Annalisa

AU - Baldini, Luca

AU - Ponzoni, Maurilio

AU - Ferreri, Andrés J.M.

AU - Franceschetti, Silvia

AU - Gaidano, Gianluca

AU - Tucci, Alessandra

AU - Facchetti, Fabio

AU - Lazure, Thierry

AU - Lambotte, Olivier

AU - Montes-Moreno, Santiago

AU - Piris, Miguel A.

AU - Zucca, Emanuele

AU - Kwee, Ivo

AU - Bertoni, Francesco

PY - 2011/5

Y1 - 2011/5

N2 - To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.

AB - To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age >60years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.

KW - Affymetrix

KW - Aggressive lymphoma

KW - Bone marrow

KW - Gain

KW - MiRNA

UR - http://www.scopus.com/inward/record.url?scp=79955035690&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.2011.08628.x

DO - 10.1111/j.1365-2141.2011.08628.x

M3 - Article

SN - 0007-1048

VL - 153

SP - 499

EP - 503

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 4

ER -

Integrated profiling of diffuse large B-cell lymphoma with 7q gain

Abstract

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