Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array

Ivo Kwee; Andrea Rinaldi; Paola Rancoita; Davide Rossi; Daniela Capello; Francesco Forconi; Nicola Giuliani; Roberto Piva; Giorgio Inghirami; Gianluca Gaidano; Emanuele Zucca; Francesco Bertoni

doi:10.1111/j.1365-2141.2011.08946.x

Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array

Ivo Kwee, Andrea Rinaldi, Paola Rancoita, Davide Rossi, Daniela Capello, Francesco Forconi, Nicola Giuliani, Roberto Piva, Giorgio Inghirami, Gianluca Gaidano, Emanuele Zucca, Francesco Bertoni

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Changes in DNA copy number (CN) and DNA methylation represent important aberrations for lymphomas and other cancers. Here, for the first time, we show that the Illumina Infinium Methylation (IIM) assay, although not originally designed for CN profiling, is able to estimate CN changes. We compared the IIM CN profiles to those obtained with a standard technique in a series of diffuse large B-cell lymphomas: the profiles showed a high degree of consensus. The demonstration of CN profiling as an additional function of the IIM assay may impact the choice of platform for methylation profiling of haematological and solid tumours.

Lingua originale	Inglese
pagine (da-a)	354-357
Numero di pagine	4
Rivista	British Journal of Haematology
Volume	156
Numero di pubblicazione	3
DOI	https://doi.org/10.1111/j.1365-2141.2011.08946.x
Stato di pubblicazione	Pubblicato - feb 2012

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10.1111/j.1365-2141.2011.08946.x

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abstract = "Changes in DNA copy number (CN) and DNA methylation represent important aberrations for lymphomas and other cancers. Here, for the first time, we show that the Illumina Infinium Methylation (IIM) assay, although not originally designed for CN profiling, is able to estimate CN changes. We compared the IIM CN profiles to those obtained with a standard technique in a series of diffuse large B-cell lymphomas: the profiles showed a high degree of consensus. The demonstration of CN profiling as an additional function of the IIM assay may impact the choice of platform for methylation profiling of haematological and solid tumours.",

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AU - Kwee, Ivo

AU - Rinaldi, Andrea

AU - Rancoita, Paola

AU - Rossi, Davide

AU - Capello, Daniela

AU - Forconi, Francesco

AU - Giuliani, Nicola

AU - Piva, Roberto

AU - Inghirami, Giorgio

AU - Gaidano, Gianluca

AU - Zucca, Emanuele

AU - Bertoni, Francesco

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AB - Changes in DNA copy number (CN) and DNA methylation represent important aberrations for lymphomas and other cancers. Here, for the first time, we show that the Illumina Infinium Methylation (IIM) assay, although not originally designed for CN profiling, is able to estimate CN changes. We compared the IIM CN profiles to those obtained with a standard technique in a series of diffuse large B-cell lymphomas: the profiles showed a high degree of consensus. The demonstration of CN profiling as an additional function of the IIM assay may impact the choice of platform for methylation profiling of haematological and solid tumours.

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Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array

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