Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer

Giorgia Colombo; Edoardo Luigi Maria Gelardi; Federica Carolina Balestrero; Marianna Moro; Cristina Travelli; Armando A. Genazzani

doi:10.3389/fphar.2021.758320

Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer

Giorgia Colombo, Edoardo Luigi Maria Gelardi, Federica Carolina Balestrero, Marianna Moro, Cristina Travelli, Armando A. Genazzani

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo di review › peer review

Abstract

Tumour cells modify their cellular metabolism with the aim to sustain uncontrolled proliferation. Cancer cells necessitate adequate amounts of NAD and NADPH to support several enzymes that are usually overexpressed and/or overactivated. Nicotinamide adenine dinucleotide (NAD) is an essential cofactor and substrate of several NAD-consuming enzymes, such as PARPs and sirtuins, while NADPH is important in the regulation of the redox status in cells. The present review explores the rationale for targeting the key enzymes that maintain the cellular NAD/NADPH pool in colorectal cancer and the enzymes that consume or use NADP(H).

Lingua originale	Inglese
Numero di articolo	758320
Rivista	Frontiers in Pharmacology
Volume	12
DOI	https://doi.org/10.3389/fphar.2021.758320
Stato di pubblicazione	Pubblicato - 22 nov 2021

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10.3389/fphar.2021.758320

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title = "Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer",

abstract = "Tumour cells modify their cellular metabolism with the aim to sustain uncontrolled proliferation. Cancer cells necessitate adequate amounts of NAD and NADPH to support several enzymes that are usually overexpressed and/or overactivated. Nicotinamide adenine dinucleotide (NAD) is an essential cofactor and substrate of several NAD-consuming enzymes, such as PARPs and sirtuins, while NADPH is important in the regulation of the redox status in cells. The present review explores the rationale for targeting the key enzymes that maintain the cellular NAD/NADPH pool in colorectal cancer and the enzymes that consume or use NADP(H).",

keywords = "ALDH = aldehyde dehydrogenase, CD38, NAD, NADPH, NAMPT (nicotinamide phosphoribosyltransferase), PARP, isocitrate dehydrogenase (IDH), sirtuins",

author = "Giorgia Colombo and Gelardi, {Edoardo Luigi Maria} and Balestrero, {Federica Carolina} and Marianna Moro and Cristina Travelli and Genazzani, {Armando A.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2021 Colombo, Gelardi, Balestrero, Moro, Travelli and Genazzani.",

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doi = "10.3389/fphar.2021.758320",

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T1 - Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer

AU - Colombo, Giorgia

AU - Gelardi, Edoardo Luigi Maria

AU - Balestrero, Federica Carolina

AU - Moro, Marianna

AU - Travelli, Cristina

AU - Genazzani, Armando A.

PY - 2021/11/22

Y1 - 2021/11/22

N2 - Tumour cells modify their cellular metabolism with the aim to sustain uncontrolled proliferation. Cancer cells necessitate adequate amounts of NAD and NADPH to support several enzymes that are usually overexpressed and/or overactivated. Nicotinamide adenine dinucleotide (NAD) is an essential cofactor and substrate of several NAD-consuming enzymes, such as PARPs and sirtuins, while NADPH is important in the regulation of the redox status in cells. The present review explores the rationale for targeting the key enzymes that maintain the cellular NAD/NADPH pool in colorectal cancer and the enzymes that consume or use NADP(H).

AB - Tumour cells modify their cellular metabolism with the aim to sustain uncontrolled proliferation. Cancer cells necessitate adequate amounts of NAD and NADPH to support several enzymes that are usually overexpressed and/or overactivated. Nicotinamide adenine dinucleotide (NAD) is an essential cofactor and substrate of several NAD-consuming enzymes, such as PARPs and sirtuins, while NADPH is important in the regulation of the redox status in cells. The present review explores the rationale for targeting the key enzymes that maintain the cellular NAD/NADPH pool in colorectal cancer and the enzymes that consume or use NADP(H).

KW - ALDH = aldehyde dehydrogenase

KW - CD38

KW - NAD

KW - NADPH

KW - NAMPT (nicotinamide phosphoribosyltransferase)

KW - PARP

KW - isocitrate dehydrogenase (IDH)

KW - sirtuins

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U2 - 10.3389/fphar.2021.758320

DO - 10.3389/fphar.2021.758320

M3 - Review article

SN - 1663-9812

VL - 12

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

M1 - 758320

ER -

Insight Into Nicotinamide Adenine Dinucleotide Homeostasis as a Targetable Metabolic Pathway in Colorectal Cancer

Abstract

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