Inhibitory effect of the somatostatin analog octreotide on rat pituitary tumor cell (GH3) proliferation in vitro

G. Pelicci, M. C. Pagliacci, L. Lanfrancone, P. G. Pelicci, F. Grignani, Ildo Nicoletti

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The effects of somatostatin-14 (SS-14) and the somatostatin-analog octreotide (SMS 201-995, Sandostatin) on proliferation of GH3 pituitary tumor cells were investigated in vitro. SMS 201-995 exerted a significant, but transient, inhibition on GH3 cell growth which reached a maximum at 24 h and was no longer detectable at 48 h. The concentration that evoked the strongest inhibitory effect was 10 nM SMS 201-995, while lower and higher doses resulted in a less pronounced effect. The inhibitory effect SMS 201-995 exerted on cell proliferation was associated with a dose- and time-related reduction in both c-myc and c-fos mRNA levels. SS-14 had no noteworthy influence on either cell proliferation or c-myc and c-fos protooncogene expression. These data demonstrate that SS-analogs transiently inhibit pituitary tumor cell proliferation in vitro.

Lingua originaleInglese
pagine (da-a)657-662
Numero di pagine6
RivistaJournal of Endocrinological Investigation
Volume13
Numero di pubblicazione8
DOI
Stato di pubblicazionePubblicato - set 1990
Pubblicato esternamente

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