TY - JOUR
T1 - Inhibitory activity of Lactobacillus plantarum P17630 against Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae
AU - Pavesi, L.
AU - Pannunzio, A.
AU - Bonetti, A.
AU - Ceresa, C.
AU - FRACCHIA, Letizia
N1 - Publisher Copyright:
© 2022 EDIZIONI MINERVA MEDICA.
PY - 2022
Y1 - 2022
N2 - BACKGROUND: The antimicrobial properties associated with lactic acid bacteria having probiotic activities have been confirmed by numerous studies. The urinary and urogenital tracts are often subjected to bacterial infections caused for about 80% by Escherichia coli, and for 20% by other bacteria including Proteus mirabilis and Klebsiella pneumoniae. The excessive use of antibiotics to eradicate these infections has contributed enormously to the development of antibiotic resistances. Therefore, the use of probiotics represents not only an important alternative but also an ethical and sustainable choice. METHODS: This study evaluated the antibacterial activity of the probiotic LAB Lactobacillus plantarum P17630 against Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae by means of the agar spot method and the agar plug diffusion test. RESULTS: Lactobacillus plantarum P17630 showed strong inhibitory activity against various strains of Escherichia coli with inhibition halos ranging between 3.80 cm and 5.09 cm, strong inhibitory activity against Klebsiella pneumoniae and intermediate against Proteus mirabilis, with average inhibition halos of 3.98 cm and 1.20 cm, respectively. CONCLUSIONS: These results confirmed the antimicrobial activity of Lactobacillus plantarum P17630 against Escherichia coli and its antibacterial activity against other bacteria implicated in urinary tract infections and vaginal infection, suggesting its wider therapeutic use in this field.
AB - BACKGROUND: The antimicrobial properties associated with lactic acid bacteria having probiotic activities have been confirmed by numerous studies. The urinary and urogenital tracts are often subjected to bacterial infections caused for about 80% by Escherichia coli, and for 20% by other bacteria including Proteus mirabilis and Klebsiella pneumoniae. The excessive use of antibiotics to eradicate these infections has contributed enormously to the development of antibiotic resistances. Therefore, the use of probiotics represents not only an important alternative but also an ethical and sustainable choice. METHODS: This study evaluated the antibacterial activity of the probiotic LAB Lactobacillus plantarum P17630 against Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae by means of the agar spot method and the agar plug diffusion test. RESULTS: Lactobacillus plantarum P17630 showed strong inhibitory activity against various strains of Escherichia coli with inhibition halos ranging between 3.80 cm and 5.09 cm, strong inhibitory activity against Klebsiella pneumoniae and intermediate against Proteus mirabilis, with average inhibition halos of 3.98 cm and 1.20 cm, respectively. CONCLUSIONS: These results confirmed the antimicrobial activity of Lactobacillus plantarum P17630 against Escherichia coli and its antibacterial activity against other bacteria implicated in urinary tract infections and vaginal infection, suggesting its wider therapeutic use in this field.
KW - Escherichia coli
KW - Klebsiella pneumoniae
KW - Lactobacillales
KW - Lactobacillus plantarum
KW - Proteus mirabilis
KW - Urinary tract infections
KW - Escherichia coli
KW - Klebsiella pneumoniae
KW - Lactobacillales
KW - Lactobacillus plantarum
KW - Proteus mirabilis
KW - Urinary tract infections
UR - https://iris.uniupo.it/handle/11579/154863
U2 - 10.23736/S0393-3660.22.04854-9
DO - 10.23736/S0393-3660.22.04854-9
M3 - Article
SN - 0393-3660
VL - 181
SP - 803
EP - 810
JO - GAZZETTA MEDICA ITALIANA. ARCHIVIO PER LE SCIENZE MEDICHE
JF - GAZZETTA MEDICA ITALIANA. ARCHIVIO PER LE SCIENZE MEDICHE
IS - 11
ER -