Inhibition of interferon-gamma may suppress allograft reactivity by T lymphocytes in vitro and in vivo

Santo Landolfo; Franca Cofano; Mirella Giovarelli; Maria Prat; Giorgio Cavallo; Guido Forni

doi:10.1126/science.3160110

Inhibition of interferon-gamma may suppress allograft reactivity by T lymphocytes in vitro and in vivo

Santo Landolfo
, Franca Cofano
, Mirella Giovarelli
, Maria Prat
, Giorgio Cavallo
, Guido Forni

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The addition to mixed-leukocyte reactions of monoclonal antibodies to interferon-γ abrogated alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity was not confined to in vitro models, since daily injection of the antibodies into CBA/J mice blocked the usual rejection of allogenic tumor cells.

Lingua originale	Inglese
pagine (da-a)	176-179
Numero di pagine	4
Rivista	Science
Volume	229
Numero di pubblicazione	4709
DOI	https://doi.org/10.1126/science.3160110
Stato di pubblicazione	Pubblicato - 1985
Pubblicato esternamente	Sì

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10.1126/science.3160110

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title = "Inhibition of interferon-gamma may suppress allograft reactivity by T lymphocytes in vitro and in vivo",

abstract = "The addition to mixed-leukocyte reactions of monoclonal antibodies to interferon-γ abrogated alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity was not confined to in vitro models, since daily injection of the antibodies into CBA/J mice blocked the usual rejection of allogenic tumor cells.",

author = "Santo Landolfo and Franca Cofano and Mirella Giovarelli and Maria Prat and Giorgio Cavallo and Guido Forni",

year = "1985",

doi = "10.1126/science.3160110",

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T1 - Inhibition of interferon-gamma may suppress allograft reactivity by T lymphocytes in vitro and in vivo

AU - Landolfo, Santo

AU - Cofano, Franca

AU - Giovarelli, Mirella

AU - Prat, Maria

AU - Cavallo, Giorgio

AU - Forni, Guido

PY - 1985

Y1 - 1985

N2 - The addition to mixed-leukocyte reactions of monoclonal antibodies to interferon-γ abrogated alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity was not confined to in vitro models, since daily injection of the antibodies into CBA/J mice blocked the usual rejection of allogenic tumor cells.

AB - The addition to mixed-leukocyte reactions of monoclonal antibodies to interferon-γ abrogated alloantigen recognition and induction of cytotoxic T lymphocytes by inducing early and highly effective suppressor T lymphocytes. This inhibitory activity was not confined to in vitro models, since daily injection of the antibodies into CBA/J mice blocked the usual rejection of allogenic tumor cells.

UR - https://www.scopus.com/pages/publications/0021984624

U2 - 10.1126/science.3160110

DO - 10.1126/science.3160110

M3 - Article

SN - 0036-8075

VL - 229

SP - 176

EP - 179

JO - Science

JF - Science

IS - 4709

ER -

Inhibition of interferon-gamma may suppress allograft reactivity by T lymphocytes in vitro and in vivo

Abstract

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