Influence of age, gender, and glucose tolerance on fasting and fed acylated ghrelin in Prader Willi syndrome

Flavia Prodam; Simonetta Bellone; Graziano Grugni; Antonino Crinò; Letizia Ragusa; Adriana Franzese; Eliana Di Battista; Andrea Corrias; Gillian Walker; Anna Rapa; Gianluca Aimaretti; Gianni Bona

doi:10.1016/j.clnu.2008.12.002

Influence of age, gender, and glucose tolerance on fasting and fed acylated ghrelin in Prader Willi syndrome

Flavia Prodam, Simonetta Bellone, Graziano Grugni, Antonino Crinò, Letizia Ragusa, Adriana Franzese, Eliana Di Battista, Andrea Corrias, Gillian Walker, Anna Rapa, Gianluca Aimaretti, Gianni Bona

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Background & aims: Prader Willi syndrome (PWS) is a genetic syndrome characterized by hyperphagia, morbid obesity, relative hypoinsulinemia and normal insulin sensitivity. PWS presents higher total (TG) and acylated ghrelin (AG) levels. The cause of this increase as well as the modulation of ghrelin secretion in fasting and feeding in relation to other metabolic parameters and glucose tolerance in PWS is largely unknown. Methods: We studied TG and AG at fasting in PWS children (14) and adults (18). We also studied TG and AG response to a mixed standardized light breakfast (SLB) in PWS adults without (AD-GT) and with glucose intolerance (AD-GI) at OGTT. Results: TG and AG were higher in children than in adults (p < 0.05). AG was higher in adult males (p < 0.001). Fasting AG and AG/TG ratio were lower in AD-GI than in AD-GT (p < 0.05). TG, but not AG, decreased in AD-GT (p < 0.006), whereas AG, but not TG, increased in AD-GI (p < 0.03) post-SLB. Fasting TG and AG were negatively predicted by fasting insulin (p < 0.05). Post-SLB AG was positively predicted by glucose during OGTT (p < 0.04). Conclusions: Fasting and post-meal AG levels are influenced by glucose tolerance in PWS, suggesting that AG derangement might have a role in the development of glucose intolerance.

Lingua originale	Inglese
pagine (da-a)	94-99
Numero di pagine	6
Rivista	Clinical Nutrition
Volume	28
Numero di pubblicazione	1
DOI	https://doi.org/10.1016/j.clnu.2008.12.002
Stato di pubblicazione	Pubblicato - feb 2009

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10.1016/j.clnu.2008.12.002

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@article{ea758b8a05784a948699833a4e0c0fcd,

title = "Influence of age, gender, and glucose tolerance on fasting and fed acylated ghrelin in Prader Willi syndrome",

abstract = "Background \& aims: Prader Willi syndrome (PWS) is a genetic syndrome characterized by hyperphagia, morbid obesity, relative hypoinsulinemia and normal insulin sensitivity. PWS presents higher total (TG) and acylated ghrelin (AG) levels. The cause of this increase as well as the modulation of ghrelin secretion in fasting and feeding in relation to other metabolic parameters and glucose tolerance in PWS is largely unknown. Methods: We studied TG and AG at fasting in PWS children (14) and adults (18). We also studied TG and AG response to a mixed standardized light breakfast (SLB) in PWS adults without (AD-GT) and with glucose intolerance (AD-GI) at OGTT. Results: TG and AG were higher in children than in adults (p < 0.05). AG was higher in adult males (p < 0.001). Fasting AG and AG/TG ratio were lower in AD-GI than in AD-GT (p < 0.05). TG, but not AG, decreased in AD-GT (p < 0.006), whereas AG, but not TG, increased in AD-GI (p < 0.03) post-SLB. Fasting TG and AG were negatively predicted by fasting insulin (p < 0.05). Post-SLB AG was positively predicted by glucose during OGTT (p < 0.04). Conclusions: Fasting and post-meal AG levels are influenced by glucose tolerance in PWS, suggesting that AG derangement might have a role in the development of glucose intolerance.",

keywords = "Acylated ghrelin, Glucose tolerance, Humans, Prader Willi syndrome",

author = "Flavia Prodam and Simonetta Bellone and Graziano Grugni and Antonino Crin{\`o} and Letizia Ragusa and Adriana Franzese and \{Di Battista\}, Eliana and Andrea Corrias and Gillian Walker and Anna Rapa and Gianluca Aimaretti and Gianni Bona",

note = "Funding Information: This study was supported by Regione Piemonte (Ricerca Finalizzata 2003, prot. n.190), and University of Piemonte Orientale. The Authors wish to thank Dr. Giuseppina Di Dio, Sara Giacoma, Silvia Savastio, Fiorella Zanetta for their technical assistance. ",

year = "2009",

month = feb,

doi = "10.1016/j.clnu.2008.12.002",

language = "English",

volume = "28",

pages = "94--99",

journal = "Clinical Nutrition",

issn = "0261-5614",

publisher = "Churchill Livingstone",

number = "1",

}

TY - JOUR

T1 - Influence of age, gender, and glucose tolerance on fasting and fed acylated ghrelin in Prader Willi syndrome

AU - Prodam, Flavia

AU - Bellone, Simonetta

AU - Grugni, Graziano

AU - Crinò, Antonino

AU - Ragusa, Letizia

AU - Franzese, Adriana

AU - Di Battista, Eliana

AU - Corrias, Andrea

AU - Walker, Gillian

AU - Rapa, Anna

AU - Aimaretti, Gianluca

AU - Bona, Gianni

N1 - Funding Information: This study was supported by Regione Piemonte (Ricerca Finalizzata 2003, prot. n.190), and University of Piemonte Orientale. The Authors wish to thank Dr. Giuseppina Di Dio, Sara Giacoma, Silvia Savastio, Fiorella Zanetta for their technical assistance.

PY - 2009/2

Y1 - 2009/2

N2 - Background & aims: Prader Willi syndrome (PWS) is a genetic syndrome characterized by hyperphagia, morbid obesity, relative hypoinsulinemia and normal insulin sensitivity. PWS presents higher total (TG) and acylated ghrelin (AG) levels. The cause of this increase as well as the modulation of ghrelin secretion in fasting and feeding in relation to other metabolic parameters and glucose tolerance in PWS is largely unknown. Methods: We studied TG and AG at fasting in PWS children (14) and adults (18). We also studied TG and AG response to a mixed standardized light breakfast (SLB) in PWS adults without (AD-GT) and with glucose intolerance (AD-GI) at OGTT. Results: TG and AG were higher in children than in adults (p < 0.05). AG was higher in adult males (p < 0.001). Fasting AG and AG/TG ratio were lower in AD-GI than in AD-GT (p < 0.05). TG, but not AG, decreased in AD-GT (p < 0.006), whereas AG, but not TG, increased in AD-GI (p < 0.03) post-SLB. Fasting TG and AG were negatively predicted by fasting insulin (p < 0.05). Post-SLB AG was positively predicted by glucose during OGTT (p < 0.04). Conclusions: Fasting and post-meal AG levels are influenced by glucose tolerance in PWS, suggesting that AG derangement might have a role in the development of glucose intolerance.

AB - Background & aims: Prader Willi syndrome (PWS) is a genetic syndrome characterized by hyperphagia, morbid obesity, relative hypoinsulinemia and normal insulin sensitivity. PWS presents higher total (TG) and acylated ghrelin (AG) levels. The cause of this increase as well as the modulation of ghrelin secretion in fasting and feeding in relation to other metabolic parameters and glucose tolerance in PWS is largely unknown. Methods: We studied TG and AG at fasting in PWS children (14) and adults (18). We also studied TG and AG response to a mixed standardized light breakfast (SLB) in PWS adults without (AD-GT) and with glucose intolerance (AD-GI) at OGTT. Results: TG and AG were higher in children than in adults (p < 0.05). AG was higher in adult males (p < 0.001). Fasting AG and AG/TG ratio were lower in AD-GI than in AD-GT (p < 0.05). TG, but not AG, decreased in AD-GT (p < 0.006), whereas AG, but not TG, increased in AD-GI (p < 0.03) post-SLB. Fasting TG and AG were negatively predicted by fasting insulin (p < 0.05). Post-SLB AG was positively predicted by glucose during OGTT (p < 0.04). Conclusions: Fasting and post-meal AG levels are influenced by glucose tolerance in PWS, suggesting that AG derangement might have a role in the development of glucose intolerance.

KW - Acylated ghrelin

KW - Glucose tolerance

KW - Humans

KW - Prader Willi syndrome

UR - http://www.scopus.com/inward/record.url?scp=59149103238&partnerID=8YFLogxK

U2 - 10.1016/j.clnu.2008.12.002

DO - 10.1016/j.clnu.2008.12.002

M3 - Article

SN - 0261-5614

VL - 28

SP - 94

EP - 99

JO - Clinical Nutrition

JF - Clinical Nutrition

IS - 1

ER -

Influence of age, gender, and glucose tolerance on fasting and fed acylated ghrelin in Prader Willi syndrome

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