TY - JOUR
T1 - Inflammatory markers and risk of epithelial ovarian cancer by tumor subtypes
T2 - The EPIC cohort
AU - Ose, Jennifer
AU - Schock, Helena
AU - Tjønneland, Anne
AU - Hansen, Louise
AU - Overvad, Kim
AU - Dossus, Laure
AU - Clavel-Chapelon, Françoise
AU - Baglietto, Laura
AU - Boeing, Heiner
AU - Trichopolou, Antonia
AU - Benetou, Vassiliki
AU - Lagiou, Pagona
AU - Masala, Giovanna
AU - Tagliabue, Giovanna
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Mattiello, Amalia
AU - Bueno-De-Mesquita, H. Bas
AU - Peeters, Petra H.M.
AU - Onland-Moret, N. Charlotte
AU - Weiderpass, Elisabete
AU - Gram, Inger T.
AU - Sánchez, Soledad
AU - Obon-Santacana, Mireia
AU - Sànchez-Pérez, Maria José
AU - Larrañaga, Nerea
AU - Castaño, Jose María Huerta
AU - Ardanaz, Eva
AU - Brändstedt, Jenny
AU - Lundin, Eva
AU - Idahl, Annika
AU - Travis, Ruth C.
AU - Khaw, Kay Tee
AU - Rinaldi, Sabina
AU - Romieu, Isabelle
AU - Merritt, Melissa A.
AU - Gunter, Marc J.
AU - Riboli, Elio
AU - Kaaks, Rudolf
AU - Fortner, Renée T.
N1 - Publisher Copyright:
© 2015 American Association for Cancer Research.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Background: Evidence suggests an etiologic role for inflammation in ovarian carcinogenesis and heterogeneity between tumor subtypes and anthropometric indices. Prospective studies on circulating inflammatory markers and epithelial invasive ovarian cancer (EOC) have predominantly investigated overall risk; data characterizing risk by tumor characteristics (histology, grade, stage, dualistic model of ovarian carcinogenesis) and anthropometric indices are sparse. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate C-reactive protein (CRP), IL6, and EOC risk by tumor characteristics. A total of 754 eligible EOC cases were identified; two controls (n = 1,497) were matched per case. We used multivariable conditional logistic regression to assess associations. Results: CRP and IL6 were not associated with overall EOC risk. However, consistent with prior research, CRP >10 versus CRP ≤1 mg/L was associated with higher overall EOC risk [OR, 1.67 (1.03-2.70)]. We did not observe significant associations or heterogeneity in analyses by tumor characteristics. In analyses stratified bywaist circumference, inflammatorymarkers were associated with higher risk among women with higher waist circumference; no association was observed for women with normal waist circumference [e.g., IL6: waist ≤80: ORlog2, 0.97 (0.81-1.16); waist >88: ORlog2, 1.78 (1.28-2.48), Pheterogeneity ≤ 0.01]. Conclusions: Our data suggest that high CRP is associated with increased risk of overall EOC, and that IL6 and CRP may be associated with EOC risk among women with higher adiposity. Impact: Our data add to global evidence that ovarian carcinogenesis may be promoted by an inflammatory milieu.
AB - Background: Evidence suggests an etiologic role for inflammation in ovarian carcinogenesis and heterogeneity between tumor subtypes and anthropometric indices. Prospective studies on circulating inflammatory markers and epithelial invasive ovarian cancer (EOC) have predominantly investigated overall risk; data characterizing risk by tumor characteristics (histology, grade, stage, dualistic model of ovarian carcinogenesis) and anthropometric indices are sparse. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate C-reactive protein (CRP), IL6, and EOC risk by tumor characteristics. A total of 754 eligible EOC cases were identified; two controls (n = 1,497) were matched per case. We used multivariable conditional logistic regression to assess associations. Results: CRP and IL6 were not associated with overall EOC risk. However, consistent with prior research, CRP >10 versus CRP ≤1 mg/L was associated with higher overall EOC risk [OR, 1.67 (1.03-2.70)]. We did not observe significant associations or heterogeneity in analyses by tumor characteristics. In analyses stratified bywaist circumference, inflammatorymarkers were associated with higher risk among women with higher waist circumference; no association was observed for women with normal waist circumference [e.g., IL6: waist ≤80: ORlog2, 0.97 (0.81-1.16); waist >88: ORlog2, 1.78 (1.28-2.48), Pheterogeneity ≤ 0.01]. Conclusions: Our data suggest that high CRP is associated with increased risk of overall EOC, and that IL6 and CRP may be associated with EOC risk among women with higher adiposity. Impact: Our data add to global evidence that ovarian carcinogenesis may be promoted by an inflammatory milieu.
UR - http://www.scopus.com/inward/record.url?scp=84941785776&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-14-1279-T
DO - 10.1158/1055-9965.EPI-14-1279-T
M3 - Article
SN - 1055-9965
VL - 24
SP - 951
EP - 961
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 6
ER -