Infection by Epstein-Barr virus in Hodgkin's disease is not restricted to the reed-sternberg cells

G. Valente; F. Negro; D. Pacchioni; G. Palestro

doi:10.1111/j.1365-2141.1994.tb04753.x

Infection by Epstein-Barr virus in Hodgkin's disease is not restricted to the reed-sternberg cells

G. Valente, F. Negro, D. Pacchioni, G. Palestro

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The presence of Epstein-Barr virus (EBV) DNA was analysed by a non- radioisotopic in situ hybridization procedure within eight Hodgkin's disease tissues. Seven specimens contained EBV DNA, that was found not only within the Reed-Sternberg tumour cells, but also, to a varying degree, within the surrounding lymphocytes. The staining was more diffuse in the nodular sclerosis and interfollicular types, whereas it involved only a minority of lymphocytes in cases with mixed cellularity. Appropriate controls established the specificity of these findings. The widespread expression of EBV DNA within Hodgkin's disease tissue heavily underscores the involvement of EBV in the pathogenesis of this illness.

Lingua originale	Inglese
pagine (da-a)	405-406
Numero di pagine	2
Rivista	British Journal of Haematology
Volume	86
Numero di pubblicazione	2
DOI	https://doi.org/10.1111/j.1365-2141.1994.tb04753.x
Stato di pubblicazione	Pubblicato - 1994
Pubblicato esternamente	Sì

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title = "Infection by Epstein-Barr virus in Hodgkin's disease is not restricted to the reed-sternberg cells",

abstract = "The presence of Epstein-Barr virus (EBV) DNA was analysed by a non- radioisotopic in situ hybridization procedure within eight Hodgkin's disease tissues. Seven specimens contained EBV DNA, that was found not only within the Reed-Sternberg tumour cells, but also, to a varying degree, within the surrounding lymphocytes. The staining was more diffuse in the nodular sclerosis and interfollicular types, whereas it involved only a minority of lymphocytes in cases with mixed cellularity. Appropriate controls established the specificity of these findings. The widespread expression of EBV DNA within Hodgkin's disease tissue heavily underscores the involvement of EBV in the pathogenesis of this illness.",

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AU - Valente, G.

AU - Negro, F.

AU - Pacchioni, D.

AU - Palestro, G.

PY - 1994

Y1 - 1994

N2 - The presence of Epstein-Barr virus (EBV) DNA was analysed by a non- radioisotopic in situ hybridization procedure within eight Hodgkin's disease tissues. Seven specimens contained EBV DNA, that was found not only within the Reed-Sternberg tumour cells, but also, to a varying degree, within the surrounding lymphocytes. The staining was more diffuse in the nodular sclerosis and interfollicular types, whereas it involved only a minority of lymphocytes in cases with mixed cellularity. Appropriate controls established the specificity of these findings. The widespread expression of EBV DNA within Hodgkin's disease tissue heavily underscores the involvement of EBV in the pathogenesis of this illness.

AB - The presence of Epstein-Barr virus (EBV) DNA was analysed by a non- radioisotopic in situ hybridization procedure within eight Hodgkin's disease tissues. Seven specimens contained EBV DNA, that was found not only within the Reed-Sternberg tumour cells, but also, to a varying degree, within the surrounding lymphocytes. The staining was more diffuse in the nodular sclerosis and interfollicular types, whereas it involved only a minority of lymphocytes in cases with mixed cellularity. Appropriate controls established the specificity of these findings. The widespread expression of EBV DNA within Hodgkin's disease tissue heavily underscores the involvement of EBV in the pathogenesis of this illness.

KW - EBV

KW - Hodgkin's disease

KW - Reed-Sternberg cells

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DO - 10.1111/j.1365-2141.1994.tb04753.x

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SN - 0007-1048

VL - 86

SP - 405

EP - 406

JO - British Journal of Haematology

JF - British Journal of Haematology

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ER -

Infection by Epstein-Barr virus in Hodgkin's disease is not restricted to the reed-sternberg cells

Abstract

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