Abstract
An in-water dehydration of N-formamides to afford isocyanides using micellar conditions at room temperature is reported. This method allows for the preparation of aliphatic isocyanides in an environmental friendly manner. The replacement of undesirable components such as phosphorous oxychloride, triethyl amine and dichloromethane (the classical combination used for the dehydration of N-formamides), by p-toluen sulphonyl chloride, sodium hydrogen carbonate and water makes this transformation really sustainable and safe.
Lingua originale | Inglese |
---|---|
pagine (da-a) | 7022-7028 |
Numero di pagine | 7 |
Rivista | Green Chemistry |
Volume | 24 |
Numero di pubblicazione | 18 |
DOI | |
Stato di pubblicazione | Pubblicato - 23 ago 2022 |