In vitro metabolism of 2-(5-ethylpyridin-2-yl)benzimidazole

O. Caputo; G. Grosa; G. Balliano; F. Rocco; G. Biglino

doi:10.1007/BF03189928

In vitro metabolism of 2-(5-ethylpyridin-2-yl)benzimidazole

O. Caputo, G. Grosa, G. Balliano, F. Rocco, G. Biglino

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The in vitro metabolic transformation of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied with phenobarbital and 3-methylcholanthrene induced rat liver microsomal fractions containing an NADPH-generating system. The major metabolite was a benzylic oxidation product and a secondary metabolite was also recovered. The metabolites were isolated by TLC and HPLC techniques and identified by comparison with known pure compounds.

Lingua originale	Inglese
pagine (da-a)	47-51
Numero di pagine	5
Rivista	European Journal of Drug Metabolism and Pharmacokinetics
Volume	13
Numero di pubblicazione	1
DOI	https://doi.org/10.1007/BF03189928
Stato di pubblicazione	Pubblicato - gen 1988
Pubblicato esternamente	Sì

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10.1007/BF03189928

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abstract = "The in vitro metabolic transformation of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied with phenobarbital and 3-methylcholanthrene induced rat liver microsomal fractions containing an NADPH-generating system. The major metabolite was a benzylic oxidation product and a secondary metabolite was also recovered. The metabolites were isolated by TLC and HPLC techniques and identified by comparison with known pure compounds.",

keywords = "2-(5-ethylpyridin-2-yl)benzimidazole, KB-1043, drug metabolism",

author = "O. Caputo and G. Grosa and G. Balliano and F. Rocco and G. Biglino",

year = "1988",

month = jan,

doi = "10.1007/BF03189928",

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AU - Caputo, O.

AU - Grosa, G.

AU - Balliano, G.

AU - Rocco, F.

AU - Biglino, G.

PY - 1988/1

Y1 - 1988/1

N2 - The in vitro metabolic transformation of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied with phenobarbital and 3-methylcholanthrene induced rat liver microsomal fractions containing an NADPH-generating system. The major metabolite was a benzylic oxidation product and a secondary metabolite was also recovered. The metabolites were isolated by TLC and HPLC techniques and identified by comparison with known pure compounds.

AB - The in vitro metabolic transformation of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied with phenobarbital and 3-methylcholanthrene induced rat liver microsomal fractions containing an NADPH-generating system. The major metabolite was a benzylic oxidation product and a secondary metabolite was also recovered. The metabolites were isolated by TLC and HPLC techniques and identified by comparison with known pure compounds.

KW - 2-(5-ethylpyridin-2-yl)benzimidazole

KW - KB-1043

KW - drug metabolism

UR - https://www.scopus.com/pages/publications/0023906036

U2 - 10.1007/BF03189928

DO - 10.1007/BF03189928

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JO - European Journal of Drug Metabolism and Pharmacokinetics

JF - European Journal of Drug Metabolism and Pharmacokinetics

IS - 1

ER -

In vitro metabolism of 2-(5-ethylpyridin-2-yl)benzimidazole

Abstract

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