TY - JOUR
T1 - In vitro efficacy of a novel potassium oxalate hydrogel for dentin hypersensitivity
AU - Varoni, Elena M.
AU - Zuccheri, Tommaso
AU - Carletta, Andrea
AU - Palazzo, Barbara
AU - Cochis, Andrea
AU - Colonna, Martino
AU - Rimondini, Lia
N1 - Publisher Copyright:
© 2017 Eur J Oral Sci
PY - 2017/4/1
Y1 - 2017/4/1
N2 - A novel potassium oxalate-based hydrogel is proposed for treating dentin hypersensitivity and this study evaluates its in vitro performance as a remineralizing, desensitizing agent. Etched disks of human dentin were treated for 10 or 20 min using the test hydrogel, to mimic a professional application with dental mouth guards. Dentin disks were evaluated in terms of permeability indexes in a fluid-filled system, the surface morphology was assessed by scanning electron microscopy, and the structural properties were studied using X-ray diffraction analysis. The potassium oxalate hydrogel significantly reduced dentin permeability, in a time-dependent manner, and occluded most of the patent dentinal tubules via crystal precipitation, forming a remineralized layer. After hydrogel treatments, an acid solution (pH 4.2) was applied to the disks for 30 s, or 1, 2, or 5 min, in order to reproduce a plaque-like oral acidity, and further analysis showed a good resistance of the remineralized layer to the acid challenge. The potassium oxalate-based hydrogel showed a better performance over commercially available products and artificial saliva, appearing a promising candidate for the treatment of dentin hypersensitivity.
AB - A novel potassium oxalate-based hydrogel is proposed for treating dentin hypersensitivity and this study evaluates its in vitro performance as a remineralizing, desensitizing agent. Etched disks of human dentin were treated for 10 or 20 min using the test hydrogel, to mimic a professional application with dental mouth guards. Dentin disks were evaluated in terms of permeability indexes in a fluid-filled system, the surface morphology was assessed by scanning electron microscopy, and the structural properties were studied using X-ray diffraction analysis. The potassium oxalate hydrogel significantly reduced dentin permeability, in a time-dependent manner, and occluded most of the patent dentinal tubules via crystal precipitation, forming a remineralized layer. After hydrogel treatments, an acid solution (pH 4.2) was applied to the disks for 30 s, or 1, 2, or 5 min, in order to reproduce a plaque-like oral acidity, and further analysis showed a good resistance of the remineralized layer to the acid challenge. The potassium oxalate-based hydrogel showed a better performance over commercially available products and artificial saliva, appearing a promising candidate for the treatment of dentin hypersensitivity.
KW - dentin desensitizing agents
KW - dentinal fluid
KW - tooth remineralization
UR - http://www.scopus.com/inward/record.url?scp=85014047103&partnerID=8YFLogxK
U2 - 10.1111/eos.12334
DO - 10.1111/eos.12334
M3 - Article
SN - 0909-8836
VL - 125
SP - 151
EP - 159
JO - European Journal of Oral Sciences
JF - European Journal of Oral Sciences
IS - 2
ER -