In vitro assessment of cytotoxicity, anti-inflammatory, antifungal properties and crystal structures of metallacyclic palladium(II) complexes

Farkhanda Shaheen; Amin Badshah; Marcel Gielen; Gianluca Croce; Ulrich Florke; Dick de Vos; Saqib Ali

doi:10.1016/j.jorganchem.2009.10.048

In vitro assessment of cytotoxicity, anti-inflammatory, antifungal properties and crystal structures of metallacyclic palladium(II) complexes

Farkhanda Shaheen, Amin Badshah, Marcel Gielen, Gianluca Croce, Ulrich Florke, Dick de Vos, Saqib Ali

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Metallacyclic palladium(II) complexes [Pd(L)(R₃P)Cl], L = TIQDTC (1,2,3,4-tetrahydroisoquinolinedithiocarbamate), 4MpipDTC (4-methylpipradinedithiocarbamate), MPizDTC (N-methylpiperazinedithiocarbamate), R₃P = Ph₃P, (o-tolyl)₃P, Ph₂ClP, were synthesized in a 1:1 molar metal-ligand ratio. These complexes were characterized by elemental analyses, FT-IR, multinuclear (¹H, ¹³C and ³¹P) NMR. The X-ray crystal structures of [Pd(TIQDTC)(Ph₃P)Cl] and [Pd(TIQDTC)((o-tolyl)₃P)Cl] show a slightly distorted square planar environment around the Pd(II) ion with S-Pd-S and P-Pd-Cl average bond angles of 74.51 and 92.41, respectively. These complexes were screened for cytotoxic, antifungal, anti-inflammatory and antibacterial activity. Some complexes exhibit a significant activity against fungi.

Lingua originale	Inglese
pagine (da-a)	315-322
Numero di pagine	8
Rivista	Journal of Organometallic Chemistry
Volume	695
Numero di pubblicazione	3
DOI	https://doi.org/10.1016/j.jorganchem.2009.10.048
Stato di pubblicazione	Pubblicato - 1 feb 2010
Pubblicato esternamente	Sì

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10.1016/j.jorganchem.2009.10.048

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@article{82fa6eab8213417e829d90b6cae075e2,

title = "In vitro assessment of cytotoxicity, anti-inflammatory, antifungal properties and crystal structures of metallacyclic palladium(II) complexes",

abstract = "Metallacyclic palladium(II) complexes [Pd(L)(R3P)Cl], L = TIQDTC (1,2,3,4-tetrahydroisoquinolinedithiocarbamate), 4MpipDTC (4-methylpipradinedithiocarbamate), MPizDTC (N-methylpiperazinedithiocarbamate), R3P = Ph3P, (o-tolyl)3P, Ph2ClP, were synthesized in a 1:1 molar metal-ligand ratio. These complexes were characterized by elemental analyses, FT-IR, multinuclear (1H, 13C and 31P) NMR. The X-ray crystal structures of [Pd(TIQDTC)(Ph3P)Cl] and [Pd(TIQDTC)((o-tolyl)3P)Cl] show a slightly distorted square planar environment around the Pd(II) ion with S-Pd-S and P-Pd-Cl average bond angles of 74.51 and 92.41, respectively. These complexes were screened for cytotoxic, antifungal, anti-inflammatory and antibacterial activity. Some complexes exhibit a significant activity against fungi.",

keywords = "Anti-inflammatory, Dithiocarbamate, Organophosphine, Palladium(II)",

author = "Farkhanda Shaheen and Amin Badshah and Marcel Gielen and Gianluca Croce and Ulrich Florke and Vos, \{Dick de\} and Saqib Ali",

year = "2010",

month = feb,

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doi = "10.1016/j.jorganchem.2009.10.048",

language = "English",

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pages = "315--322",

journal = "Journal of Organometallic Chemistry",

issn = "0022-328X",

publisher = "Elsevier B.V.",

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In vitro assessment of cytotoxicity, anti-inflammatory, antifungal properties and crystal structures of metallacyclic palladium(II) complexes. / Shaheen, Farkhanda; Badshah, Amin; Gielen, Marcel et al.
In: Journal of Organometallic Chemistry, Vol. 695, N. 3, 01.02.2010, pag. 315-322.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - In vitro assessment of cytotoxicity, anti-inflammatory, antifungal properties and crystal structures of metallacyclic palladium(II) complexes

AU - Shaheen, Farkhanda

AU - Badshah, Amin

AU - Gielen, Marcel

AU - Croce, Gianluca

AU - Florke, Ulrich

AU - Vos, Dick de

AU - Ali, Saqib

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Metallacyclic palladium(II) complexes [Pd(L)(R3P)Cl], L = TIQDTC (1,2,3,4-tetrahydroisoquinolinedithiocarbamate), 4MpipDTC (4-methylpipradinedithiocarbamate), MPizDTC (N-methylpiperazinedithiocarbamate), R3P = Ph3P, (o-tolyl)3P, Ph2ClP, were synthesized in a 1:1 molar metal-ligand ratio. These complexes were characterized by elemental analyses, FT-IR, multinuclear (1H, 13C and 31P) NMR. The X-ray crystal structures of [Pd(TIQDTC)(Ph3P)Cl] and [Pd(TIQDTC)((o-tolyl)3P)Cl] show a slightly distorted square planar environment around the Pd(II) ion with S-Pd-S and P-Pd-Cl average bond angles of 74.51 and 92.41, respectively. These complexes were screened for cytotoxic, antifungal, anti-inflammatory and antibacterial activity. Some complexes exhibit a significant activity against fungi.

AB - Metallacyclic palladium(II) complexes [Pd(L)(R3P)Cl], L = TIQDTC (1,2,3,4-tetrahydroisoquinolinedithiocarbamate), 4MpipDTC (4-methylpipradinedithiocarbamate), MPizDTC (N-methylpiperazinedithiocarbamate), R3P = Ph3P, (o-tolyl)3P, Ph2ClP, were synthesized in a 1:1 molar metal-ligand ratio. These complexes were characterized by elemental analyses, FT-IR, multinuclear (1H, 13C and 31P) NMR. The X-ray crystal structures of [Pd(TIQDTC)(Ph3P)Cl] and [Pd(TIQDTC)((o-tolyl)3P)Cl] show a slightly distorted square planar environment around the Pd(II) ion with S-Pd-S and P-Pd-Cl average bond angles of 74.51 and 92.41, respectively. These complexes were screened for cytotoxic, antifungal, anti-inflammatory and antibacterial activity. Some complexes exhibit a significant activity against fungi.

KW - Anti-inflammatory

KW - Dithiocarbamate

KW - Organophosphine

KW - Palladium(II)

UR - https://www.scopus.com/pages/publications/74049115857

U2 - 10.1016/j.jorganchem.2009.10.048

DO - 10.1016/j.jorganchem.2009.10.048

M3 - Article

SN - 0022-328X

VL - 695

SP - 315

EP - 322

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

IS - 3

ER -

In vitro assessment of cytotoxicity, anti-inflammatory, antifungal properties and crystal structures of metallacyclic palladium(II) complexes

Abstract

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