In vitro and in vivo antiserotoninergic effects of 1-isopropylnoradreno-chrome-5-monosemicarbazone (divascan®)

A. Prato; M. Amico-Roxas; P. L. Canonico; F. Drago; G. Clementi

doi:10.1016/S0031-6989(80)80079-8

In vitro and in vivo antiserotoninergic effects of 1-isopropylnoradreno-chrome-5-monosemicarbazone (divascan®)

A. Prato, M. Amico-Roxas, P. L. Canonico, F. Drago, G. Clementi

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The antiserotoninergic action of Divascan® was tested "in vitro" and "in vivo" The drug was able to counteract serotonin-induced contractions of rat stomach strips, in a reversible and dose-dependent manner, but not histamine or acetylcholine-induced contractions of the guines pig iteum. "In vivo" the drug depressed the diurnal and nocturnal peaks of prolactin (Prl) (4 pm - 12 pm). The "in vitro" and "in vivo" results suggest that Divascan® has a significant antagonistic activity on only serotonin-induced rat stomach contractions and thus an inhibitory action on the central 5-HT neurons by abolishing the circadian ciclicity of Plasma Prl levels.

Lingua originale	Inglese
pagine (da-a)	751-756
Numero di pagine	6
Rivista	Pharmacological Research Communications
Volume	12
Numero di pubblicazione	8
DOI	https://doi.org/10.1016/S0031-6989(80)80079-8
Stato di pubblicazione	Pubblicato - set 1980
Pubblicato esternamente	Sì

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10.1016/S0031-6989(80)80079-8

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title = "In vitro and in vivo antiserotoninergic effects of 1-isopropylnoradreno-chrome-5-monosemicarbazone (divascan{\textregistered})",

abstract = "The antiserotoninergic action of Divascan{\textregistered} was tested {"}in vitro{"} and {"}in vivo{"} The drug was able to counteract serotonin-induced contractions of rat stomach strips, in a reversible and dose-dependent manner, but not histamine or acetylcholine-induced contractions of the guines pig iteum. {"}In vivo{"} the drug depressed the diurnal and nocturnal peaks of prolactin (Prl) (4 pm - 12 pm). The {"}in vitro{"} and {"}in vivo{"} results suggest that Divascan{\textregistered} has a significant antagonistic activity on only serotonin-induced rat stomach contractions and thus an inhibitory action on the central 5-HT neurons by abolishing the circadian ciclicity of Plasma Prl levels.",

author = "A. Prato and M. Amico-Roxas and Canonico, {P. L.} and F. Drago and G. Clementi",

year = "1980",

month = sep,

doi = "10.1016/S0031-6989(80)80079-8",

language = "English",

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journal = "Pharmacological Research Communications",

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TY - JOUR

T1 - In vitro and in vivo antiserotoninergic effects of 1-isopropylnoradreno-chrome-5-monosemicarbazone (divascan®)

AU - Prato, A.

AU - Amico-Roxas, M.

AU - Canonico, P. L.

AU - Drago, F.

AU - Clementi, G.

PY - 1980/9

Y1 - 1980/9

N2 - The antiserotoninergic action of Divascan® was tested "in vitro" and "in vivo" The drug was able to counteract serotonin-induced contractions of rat stomach strips, in a reversible and dose-dependent manner, but not histamine or acetylcholine-induced contractions of the guines pig iteum. "In vivo" the drug depressed the diurnal and nocturnal peaks of prolactin (Prl) (4 pm - 12 pm). The "in vitro" and "in vivo" results suggest that Divascan® has a significant antagonistic activity on only serotonin-induced rat stomach contractions and thus an inhibitory action on the central 5-HT neurons by abolishing the circadian ciclicity of Plasma Prl levels.

AB - The antiserotoninergic action of Divascan® was tested "in vitro" and "in vivo" The drug was able to counteract serotonin-induced contractions of rat stomach strips, in a reversible and dose-dependent manner, but not histamine or acetylcholine-induced contractions of the guines pig iteum. "In vivo" the drug depressed the diurnal and nocturnal peaks of prolactin (Prl) (4 pm - 12 pm). The "in vitro" and "in vivo" results suggest that Divascan® has a significant antagonistic activity on only serotonin-induced rat stomach contractions and thus an inhibitory action on the central 5-HT neurons by abolishing the circadian ciclicity of Plasma Prl levels.

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U2 - 10.1016/S0031-6989(80)80079-8

DO - 10.1016/S0031-6989(80)80079-8

M3 - Article

SN - 0031-6989

VL - 12

SP - 751

EP - 756

JO - Pharmacological Research Communications

JF - Pharmacological Research Communications

IS - 8

ER -

In vitro and in vivo antiserotoninergic effects of 1-isopropylnoradreno-chrome-5-monosemicarbazone (divascan®)

Abstract

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