Impurity analysis of retinoic acid samples

Gianna Allegrone, Elisabetta Brenna, Giovanni Fronza, Claudio Fuganti, Tommaso Giovenzana, Luciana Malpezzi, Enrico Barlocchi, Cesare Pellegatta

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The structure of an impurity contained in samples of all trans-retinoic acid was established by means of NMR and MS spectra, and confirmed by X-ray diffraction analysis. The chemical structure of the impurity 2 was found to be strictly correlated to the synthetic procedure employed for the preparation of the retinoic acid samples. Single crystal analysis allowed us to characterise the molecular conformation and the crystal structure of 2.

Lingua originaleInglese
pagine (da-a)3528-3531
Numero di pagine4
RivistaBioorganic and Medicinal Chemistry Letters
Volume15
Numero di pubblicazione15
DOI
Stato di pubblicazionePubblicato - 1 ago 2005

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