Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy: A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study)

Alessandro Antonelli; Carlotta Palumbo; Marianna Noale; Angelo Porreca; Stefania Maggi; Claudio Simeone; Pierfrancesco Bassi; Filippo Bertoni; Sergio Bracarda; Michela Buglione; Giario Natale Conti; Renzo Corvò; Mauro Gacci; Vincenzo Mirone; Rodolfo Montironi; Luca Triggiani; Andrea Tubaro; Walter Artibani; Gaetano Crepaldi; Pierpaolo Graziotti; Elvio Russi; Maria Magrini Stefano; Giovanni Muto; Stefano Pecoraro; Umberto Ricardi; Vittorina Zagonel; Rita Alitto Anna; Enrica Ambrosi; Cynthia Aristei; Michele Barbieri; Franco Bardari; Lilia Bardoscia; Salvina Barra; Sara Bartoncini; Umberto Basso; Carlotta Becherini; Rita Bellavita; Franco Bergamaschi; Stefania Berlingheri; Alfredo Berruti; Marco Borghesi; Roberto Bortolus; Valentina Borzillo; Davide Bosetti; Giuseppe Bove; Pierluigi Bove; Maurizio Brausi; Alessio Bruni; Giorgio Bruno; Eugenio Brunocilla; Alberto Buffoli; Consuelo Buttigliero; Giovanni Cacciamani; Michela Caldiroli; Giuseppe Cardo; Giorgio Carmignani; Giuseppe Carrieri; Emanuele Castelli; Elisabetta Castrezzati; Gianpiero Catalano; Susanna Cattarino; Francesco Catucci; Francolini Dario Cavallini; Ofelia Ceccarini; Antonio Celia; Francesco Chiancone; Tommaso Chini; Claudia Cianci; Antonio Cisternino; Devis Collura; Franco Corbella; Matteo Corinti; Paolo Corsi; Fiorenza Cortese; Luigi Corti; Nunzio de Cosimo; Olga Cristiano; Rolando D'Angelillo; Luigi Da Pozzo; Daniele D'agostino; Carolina D'Elia; Matteo Dandrea; De Michele De Angelis; Paolo De Angelis; Ottavio De Cobelli; Bernardino De Concilio; Antonello De Lisa; Stefano De Luca; Agostina De Stefani; Chiara Lucrezia Deantoni; Claudio Degli Esposti; Anna Destito; Beatrice Detti; Nadia Di Muzio; Andrea Di Stasio; Calogero Di Stefano; Danilo Di Trapani; Giuseppe Difino; Sara Falivene; Giuseppe Farullo; Paolo Fedelini; Ilaria Ferrari; Francesco Ferraù; Matteo Ferro; Andrei Fodor; Francesco Fontana; Francesco Francesca; Giulio Francolini; Paolo Frata; Giovanni Frezza; Pietro Gabriele; Maria Galeandro; Elisabetta Garibaldi; Giovanni Gennari Pietro; Alessandro Gentilucci; Alessandro Giacobbe; Laura Giussani; Giuseppe Giusti; Paolo Gontero; Alessia Guarneri; Cesare Guida; Alberto Gurioli; Dorijan Huqi; Ciro Imbimbo; Gianluca Ingrosso; Cinzia Iotti; Corrado Italia; Pierdaniele La Mattina; Enza Lamanna; Luciana Lastrucci; Grazia Lazzari; Fabiola Liberale; Giovanni Liguori; Roberto Lisi; Frank Lohr; Riccardo Lombardo; Jon A.J. Lovisolo; Mario Ludovico Giuseppe; Nicola Macchione; Francesca Maggio; Michele Malizia; Gianluca Manasse; Giovanni Mandoliti; Giovanna Mantini; Luigi Marafioti; Luisa Marciello; Mario Marconi Alberto; Antonietta Martilotta; Salvino Marzano; Stefano Masciullo; Gloria Maso; Adele Massenzo; Ercole Mazzeo; Luigi Mearini; Serena Medoro; Rosa Molè; Giorgio Monesi; Emanuele Montanari; Franco Montefiore; Giampaolo Montesi; Giuseppe Morgia; Gregorio Moro; Giorgio Muscas; Daniela Musio; Paolo Muto; Giovanni Muzzonigro; Giorgio Napodano; Carlo Luigi Augusto Negro; Mattia Nidini; Maria Ntreta; Marco Orsatti; Carmela Palazzolo; Isabella Palumbo; Alessandro Parisi; Paolo Parma; Nicola Pavan; Martina Pericolini; Francesco Pinto; Antonio Pistone; Valerio Pizzuti; Angelo Platania; Caterina Polli; Giorgio Pomara; Elisabetta Ponti; Antonio Benito Porcaro; Francesco Porpiglia; Dario Pugliese; Armin Pycha; Giuseppe Raguso; Andrea Rampini; Franco Randone Donato; Valentina Roboldi; Marco Roscigno; Maria Paola Ruggieri; Giuseppe Ruoppo; Roberto Sanseverino; Anna Santacaterina; Michele Santarsieri; Riccardo Santoni; Sarah Scagliarini; Vittorio Scagliotti Giorgio; Mauro Scanzi; Marcello Scarcia; Riccardo Schiavina; Alessandro Sciarra; Carmine Sciorio; Tindaro Scolaro; Salvatore Scuzzarella; Oscar Selvaggio; Armando Serao; Sergio Serni; Marco Andrea Signor; Mauro Silvani; Giovanni Silvano; Franco Silvestris; Valeria Simone; Girolamo Spagnoletti; Giulio Spinelli Matteo; Luigi Squillace; Vincenzo Tombolini; Mariastella Toninelli; Alberto Trinchieri; Luca Eolo Trodella; Lucio Trodella; Carlo Trombetta; Lidia Tronnolone; Marcello Tucci; Daniele Urzì; Riccardo Valdagni; Maurizio Valeriani; Maurizio Vanoli; Elisabetta Vitali; Alessandro Volpe; Stefano Zaramella; Guglielmo Zeccolini; Giampaolo Zini

doi:10.1159/000496980

Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy: A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study)

Alessandro Antonelli, Carlotta Palumbo, Marianna Noale, Angelo Porreca, Stefania Maggi, Claudio Simeone, Pierfrancesco Bassi, Filippo Bertoni, Sergio Bracarda, Michela Buglione, Giario Natale Conti, Renzo Corvò, Mauro Gacci, Vincenzo Mirone, Rodolfo Montironi, Luca Triggiani, Andrea Tubaro, Walter Artibani, Gaetano Crepaldi, Pierpaolo GraziottiElvio Russi, Maria Magrini Stefano, Giovanni Muto, Stefano Pecoraro, Umberto Ricardi, Vittorina Zagonel, Rita Alitto Anna, Enrica Ambrosi, Cynthia Aristei, Michele Barbieri, Franco Bardari, Lilia Bardoscia, Salvina Barra, Sara Bartoncini, Umberto Basso, Carlotta Becherini, Rita Bellavita, Franco Bergamaschi, Stefania Berlingheri, Alfredo Berruti, Marco Borghesi, Roberto Bortolus, Valentina Borzillo, Davide Bosetti, Giuseppe Bove, Pierluigi Bove, Maurizio Brausi, Alessio Bruni, Giorgio Bruno, Eugenio Brunocilla, Alberto Buffoli, Consuelo Buttigliero, Giovanni Cacciamani, Michela Caldiroli, Giuseppe Cardo, Giorgio Carmignani, Giuseppe Carrieri, Emanuele Castelli, Elisabetta Castrezzati, Gianpiero Catalano, Susanna Cattarino, Francesco Catucci, Francolini Dario Cavallini, Ofelia Ceccarini, Antonio Celia, Francesco Chiancone, Tommaso Chini, Claudia Cianci, Antonio Cisternino, Devis Collura, Franco Corbella, Matteo Corinti, Paolo Corsi, Fiorenza Cortese, Luigi Corti, Nunzio de Cosimo, Olga Cristiano, Rolando D'Angelillo, Luigi Da Pozzo, Daniele D'agostino, Carolina D'Elia, Matteo Dandrea, De Michele De Angelis, Paolo De Angelis, Ottavio De Cobelli, Bernardino De Concilio, Antonello De Lisa, Stefano De Luca, Agostina De Stefani, Chiara Lucrezia Deantoni, Claudio Degli Esposti, Anna Destito, Beatrice Detti, Nadia Di Muzio, Andrea Di Stasio, Calogero Di Stefano, Danilo Di Trapani, Giuseppe Difino, Sara Falivene, Giuseppe Farullo, Paolo Fedelini, Ilaria Ferrari, Francesco Ferraù, Matteo Ferro, Andrei Fodor, Francesco Fontana, Francesco Francesca, Giulio Francolini, Paolo Frata, Giovanni Frezza, Pietro Gabriele, Maria Galeandro, Elisabetta Garibaldi, Giovanni Gennari Pietro, Alessandro Gentilucci, Alessandro Giacobbe, Laura Giussani, Giuseppe Giusti, Paolo Gontero, Alessia Guarneri, Cesare Guida, Alberto Gurioli, Dorijan Huqi, Ciro Imbimbo, Gianluca Ingrosso, Cinzia Iotti, Corrado Italia, Pierdaniele La Mattina, Enza Lamanna, Luciana Lastrucci, Grazia Lazzari, Fabiola Liberale, Giovanni Liguori, Roberto Lisi, Frank Lohr, Riccardo Lombardo, Jon A.J. Lovisolo, Mario Ludovico Giuseppe, Nicola Macchione, Francesca Maggio, Michele Malizia, Gianluca Manasse, Giovanni Mandoliti, Giovanna Mantini, Luigi Marafioti, Luisa Marciello, Mario Marconi Alberto, Antonietta Martilotta, Salvino Marzano, Stefano Masciullo, Gloria Maso, Adele Massenzo, Ercole Mazzeo, Luigi Mearini, Serena Medoro, Rosa Molè, Giorgio Monesi, Emanuele Montanari, Franco Montefiore, Giampaolo Montesi, Giuseppe Morgia, Gregorio Moro, Giorgio Muscas, Daniela Musio, Paolo Muto, Giovanni Muzzonigro, Giorgio Napodano, Carlo Luigi Augusto Negro, Mattia Nidini, Maria Ntreta, Marco Orsatti, Carmela Palazzolo, Isabella Palumbo, Alessandro Parisi, Paolo Parma, Nicola Pavan, Martina Pericolini, Francesco Pinto, Antonio Pistone, Valerio Pizzuti, Angelo Platania, Caterina Polli, Giorgio Pomara, Elisabetta Ponti, Antonio Benito Porcaro, Francesco Porpiglia, Dario Pugliese, Armin Pycha, Giuseppe Raguso, Andrea Rampini, Franco Randone Donato, Valentina Roboldi, Marco Roscigno, Maria Paola Ruggieri, Giuseppe Ruoppo, Roberto Sanseverino, Anna Santacaterina, Michele Santarsieri, Riccardo Santoni, Sarah Scagliarini, Vittorio Scagliotti Giorgio, Mauro Scanzi, Marcello Scarcia, Riccardo Schiavina, Alessandro Sciarra, Carmine Sciorio, Tindaro Scolaro, Salvatore Scuzzarella, Oscar Selvaggio, Armando Serao, Sergio Serni, Marco Andrea Signor, Mauro Silvani, Giovanni Silvano, Franco Silvestris, Valeria Simone, Girolamo Spagnoletti, Giulio Spinelli Matteo, Luigi Squillace, Vincenzo Tombolini, Mariastella Toninelli, Alberto Trinchieri, Luca Eolo Trodella, Lucio Trodella, Carlo Trombetta, Lidia Tronnolone, Marcello Tucci, Daniele Urzì, Riccardo Valdagni, Maurizio Valeriani, Maurizio Vanoli, Elisabetta Vitali, Alessandro Volpe, Stefano Zaramella, Guglielmo Zeccolini, Giampaolo Zini

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Background: To report health-related quality of life outcomes as assessed by validated patient-reported outcome measures (PROMs) after radical prostatectomy (RP).-Methods: This study analyzed patients treated with RP within The PROState cancer monitoring in Italy, from the National Research Council (Pros-IT CNR). Italian versions of Short-Form Heath Survey and university of California los Angeles-prostate cancer index questionnaires were administered. PROMs were physical composite scores, mental composite scores and urinary, bowel, sexual functions and bothers (UF/B, BF/B, SF/B). Baseline unbalances were controlled with propensity scores and stabilized inverse weights; differences in PROMs between different RP approaches were estimated by mixed models. Results: Of 541 patients treated with RP, 115 (21%) received open RP (ORP), 90 (17%) laparoscopic RP (LRP) and 336 (61%) robot-assisted RP (RARP). At head-to-head-comparisons, RARP showed higher 12-month UF vs. LRP (interaction treatment ∗ time p = 0.03) and 6-month SF vs. ORP (p < 0.001). At 12-month from surgery, 67, 73 and 79% of patients used no pad for urinary loss in ORP, LRP and RARP respectively (no differences for each comparison). Conversely, 16, 27 and 40% of patients declared erections firm enough for sexual intercourse in ORP, LRP and RARP respectively (only significant difference for ORP vs. RARP, p = 0.0004). Conclusions: Different RP approaches lead to significant variations in urinary and sexual PROMs, with a general trend in favour of RARP. However, their clinical significance seems limited.

Lingua originale	Inglese
pagine (da-a)	8-18
Numero di pagine	11
Rivista	Urologia Internationalis
Volume	103
Numero di pubblicazione	1
DOI	https://doi.org/10.1159/000496980
Stato di pubblicazione	Pubblicato - 1 lug 2019

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10.1159/000496980

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Antonelli, A., Palumbo, C., Noale, M., Porreca, A., Maggi, S., Simeone, C., Bassi, P., Bertoni, F., Bracarda, S., Buglione, M., Conti, G. N., Corvò, R., Gacci, M., Mirone, V., Montironi, R., Triggiani, L., Tubaro, A., Artibani, W., Crepaldi, G., ... Zini, G. (2019). Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy: A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study). Urologia Internationalis, 103(1), 8-18. https://doi.org/10.1159/000496980

@article{7027340d9d614bde8cfd28c0d060b3ec,

title = "Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy: A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study)",

abstract = "Background: To report health-related quality of life outcomes as assessed by validated patient-reported outcome measures (PROMs) after radical prostatectomy (RP).-Methods: This study analyzed patients treated with RP within The PROState cancer monitoring in Italy, from the National Research Council (Pros-IT CNR). Italian versions of Short-Form Heath Survey and university of California los Angeles-prostate cancer index questionnaires were administered. PROMs were physical composite scores, mental composite scores and urinary, bowel, sexual functions and bothers (UF/B, BF/B, SF/B). Baseline unbalances were controlled with propensity scores and stabilized inverse weights; differences in PROMs between different RP approaches were estimated by mixed models. Results: Of 541 patients treated with RP, 115 (21%) received open RP (ORP), 90 (17%) laparoscopic RP (LRP) and 336 (61%) robot-assisted RP (RARP). At head-to-head-comparisons, RARP showed higher 12-month UF vs. LRP (interaction treatment ∗ time p = 0.03) and 6-month SF vs. ORP (p < 0.001). At 12-month from surgery, 67, 73 and 79% of patients used no pad for urinary loss in ORP, LRP and RARP respectively (no differences for each comparison). Conversely, 16, 27 and 40% of patients declared erections firm enough for sexual intercourse in ORP, LRP and RARP respectively (only significant difference for ORP vs. RARP, p = 0.0004). Conclusions: Different RP approaches lead to significant variations in urinary and sexual PROMs, with a general trend in favour of RARP. However, their clinical significance seems limited.",

keywords = "Patient-reported outcome measures, Prostate cancer, Quality of life, Radical prostatectomy, Sexual function, Urinary function",

author = "Alessandro Antonelli and Carlotta Palumbo and Marianna Noale and Angelo Porreca and Stefania Maggi and Claudio Simeone and Pierfrancesco Bassi and Filippo Bertoni and Sergio Bracarda and Michela Buglione and Conti, {Giario Natale} and Renzo Corv{\`o} and Mauro Gacci and Vincenzo Mirone and Rodolfo Montironi and Luca Triggiani and Andrea Tubaro and Walter Artibani and Gaetano Crepaldi and Pierpaolo Graziotti and Elvio Russi and {Magrini Stefano}, Maria and Giovanni Muto and Stefano Pecoraro and Umberto Ricardi and Vittorina Zagonel and {Alitto Anna}, Rita and Enrica Ambrosi and Cynthia Aristei and Michele Barbieri and Franco Bardari and Lilia Bardoscia and Salvina Barra and Sara Bartoncini and Umberto Basso and Carlotta Becherini and Rita Bellavita and Franco Bergamaschi and Stefania Berlingheri and Alfredo Berruti and Marco Borghesi and Roberto Bortolus and Valentina Borzillo and Davide Bosetti and Giuseppe Bove and Pierluigi Bove and Maurizio Brausi and Alessio Bruni and Giorgio Bruno and Eugenio Brunocilla and Alberto Buffoli and Consuelo Buttigliero and Giovanni Cacciamani and Michela Caldiroli and Giuseppe Cardo and Giorgio Carmignani and Giuseppe Carrieri and Emanuele Castelli and Elisabetta Castrezzati and Gianpiero Catalano and Susanna Cattarino and Francesco Catucci and Cavallini, {Francolini Dario} and Ofelia Ceccarini and Antonio Celia and Francesco Chiancone and Tommaso Chini and Claudia Cianci and Antonio Cisternino and Devis Collura and Franco Corbella and Matteo Corinti and Paolo Corsi and Fiorenza Cortese and Luigi Corti and {de Cosimo}, Nunzio and Olga Cristiano and Rolando D'Angelillo and {Da Pozzo}, Luigi and Daniele D'agostino and Carolina D'Elia and Matteo Dandrea and {De Angelis}, {De Michele} and {De Angelis}, Paolo and {De Cobelli}, Ottavio and {De Concilio}, Bernardino and {De Lisa}, Antonello and {De Luca}, Stefano and {De Stefani}, Agostina and Deantoni, {Chiara Lucrezia} and {Degli Esposti}, Claudio and Anna Destito and Beatrice Detti and {Di Muzio}, Nadia and {Di Stasio}, Andrea and {Di Stefano}, Calogero and {Di Trapani}, Danilo and Giuseppe Difino and Sara Falivene and Giuseppe Farullo and Paolo Fedelini and Ilaria Ferrari and Francesco Ferra{\`u} and Matteo Ferro and Andrei Fodor and Francesco Fontana and Francesco Francesca and Giulio Francolini and Paolo Frata and Giovanni Frezza and Pietro Gabriele and Maria Galeandro and Elisabetta Garibaldi and {Gennari Pietro}, Giovanni and Alessandro Gentilucci and Alessandro Giacobbe and Laura Giussani and Giuseppe Giusti and Paolo Gontero and Alessia Guarneri and Cesare Guida and Alberto Gurioli and Dorijan Huqi and Ciro Imbimbo and Gianluca Ingrosso and Cinzia Iotti and Corrado Italia and {La Mattina}, Pierdaniele and Enza Lamanna and Luciana Lastrucci and Grazia Lazzari and Fabiola Liberale and Giovanni Liguori and Roberto Lisi and Frank Lohr and Riccardo Lombardo and Lovisolo, {Jon A.J.} and {Ludovico Giuseppe}, Mario and Nicola Macchione and Francesca Maggio and Michele Malizia and Gianluca Manasse and Giovanni Mandoliti and Giovanna Mantini and Luigi Marafioti and Luisa Marciello and {Marconi Alberto}, Mario and Antonietta Martilotta and Salvino Marzano and Stefano Masciullo and Gloria Maso and Adele Massenzo and Ercole Mazzeo and Luigi Mearini and Serena Medoro and Rosa Mol{\`e} and Giorgio Monesi and Emanuele Montanari and Franco Montefiore and Giampaolo Montesi and Giuseppe Morgia and Gregorio Moro and Giorgio Muscas and Daniela Musio and Paolo Muto and Giovanni Muzzonigro and Giorgio Napodano and Negro, {Carlo Luigi Augusto} and Mattia Nidini and Maria Ntreta and Marco Orsatti and Carmela Palazzolo and Isabella Palumbo and Alessandro Parisi and Paolo Parma and Nicola Pavan and Martina Pericolini and Francesco Pinto and Antonio Pistone and Valerio Pizzuti and Angelo Platania and Caterina Polli and Giorgio Pomara and Elisabetta Ponti and Porcaro, {Antonio Benito} and Francesco Porpiglia and Dario Pugliese and Armin Pycha and Giuseppe Raguso and Andrea Rampini and {Randone Donato}, Franco and Valentina Roboldi and Marco Roscigno and Ruggieri, {Maria Paola} and Giuseppe Ruoppo and Roberto Sanseverino and Anna Santacaterina and Michele Santarsieri and Riccardo Santoni and Sarah Scagliarini and {Scagliotti Giorgio}, Vittorio and Mauro Scanzi and Marcello Scarcia and Riccardo Schiavina and Alessandro Sciarra and Carmine Sciorio and Tindaro Scolaro and Salvatore Scuzzarella and Oscar Selvaggio and Armando Serao and Sergio Serni and Signor, {Marco Andrea} and Mauro Silvani and Giovanni Silvano and Franco Silvestris and Valeria Simone and Girolamo Spagnoletti and {Spinelli Matteo}, Giulio and Luigi Squillace and Vincenzo Tombolini and Mariastella Toninelli and Alberto Trinchieri and Trodella, {Luca Eolo} and Lucio Trodella and Carlo Trombetta and Lidia Tronnolone and Marcello Tucci and Daniele Urz{\`i} and Riccardo Valdagni and Maurizio Valeriani and Maurizio Vanoli and Elisabetta Vitali and Alessandro Volpe and Stefano Zaramella and Guglielmo Zeccolini and Giampaolo Zini",

year = "2019",

month = jul,

day = "1",

doi = "10.1159/000496980",

language = "English",

volume = "103",

pages = "8--18",

journal = "Urologia Internationalis",

issn = "0042-1138",

publisher = "S. Karger AG",

number = "1",

}

Antonelli, A, Palumbo, C, Noale, M, Porreca, A, Maggi, S, Simeone, C, Bassi, P, Bertoni, F, Bracarda, S, Buglione, M, Conti, GN, Corvò, R, Gacci, M, Mirone, V, Montironi, R, Triggiani, L, Tubaro, A, Artibani, W, Crepaldi, G, Graziotti, P, Russi, E, Magrini Stefano, M, Muto, G, Pecoraro, S, Ricardi, U, Zagonel, V, Alitto Anna, R, Ambrosi, E, Aristei, C, Barbieri, M, Bardari, F, Bardoscia, L, Barra, S, Bartoncini, S, Basso, U, Becherini, C, Bellavita, R, Bergamaschi, F, Berlingheri, S, Berruti, A, Borghesi, M, Bortolus, R, Borzillo, V, Bosetti, D, Bove, G, Bove, P, Brausi, M, Bruni, A, Bruno, G, Brunocilla, E, Buffoli, A, Buttigliero, C, Cacciamani, G, Caldiroli, M, Cardo, G, Carmignani, G, Carrieri, G, Castelli, E, Castrezzati, E, Catalano, G, Cattarino, S, Catucci, F, Cavallini, FD, Ceccarini, O, Celia, A, Chiancone, F, Chini, T, Cianci, C, Cisternino, A, Collura, D, Corbella, F, Corinti, M, Corsi, P, Cortese, F, Corti, L, de Cosimo, N, Cristiano, O, D'Angelillo, R, Da Pozzo, L, D'agostino, D, D'Elia, C, Dandrea, M, De Angelis, DM, De Angelis, P, De Cobelli, O, De Concilio, B, De Lisa, A, De Luca, S, De Stefani, A, Deantoni, CL, Degli Esposti, C, Destito, A, Detti, B, Di Muzio, N, Di Stasio, A, Di Stefano, C, Di Trapani, D, Difino, G, Falivene, S, Farullo, G, Fedelini, P, Ferrari, I, Ferraù, F, Ferro, M, Fodor, A, Fontana, F, Francesca, F, Francolini, G, Frata, P, Frezza, G, Gabriele, P, Galeandro, M, Garibaldi, E, Gennari Pietro, G, Gentilucci, A, Giacobbe, A, Giussani, L, Giusti, G, Gontero, P, Guarneri, A, Guida, C, Gurioli, A, Huqi, D, Imbimbo, C, Ingrosso, G, Iotti, C, Italia, C, La Mattina, P, Lamanna, E, Lastrucci, L, Lazzari, G, Liberale, F, Liguori, G, Lisi, R, Lohr, F, Lombardo, R, Lovisolo, JAJ, Ludovico Giuseppe, M, Macchione, N, Maggio, F, Malizia, M, Manasse, G, Mandoliti, G, Mantini, G, Marafioti, L, Marciello, L, Marconi Alberto, M, Martilotta, A, Marzano, S, Masciullo, S, Maso, G, Massenzo, A, Mazzeo, E, Mearini, L, Medoro, S, Molè, R, Monesi, G, Montanari, E, Montefiore, F, Montesi, G, Morgia, G, Moro, G, Muscas, G, Musio, D, Muto, P, Muzzonigro, G, Napodano, G, Negro, CLA, Nidini, M, Ntreta, M, Orsatti, M, Palazzolo, C, Palumbo, I, Parisi, A, Parma, P, Pavan, N, Pericolini, M, Pinto, F, Pistone, A, Pizzuti, V, Platania, A, Polli, C, Pomara, G, Ponti, E, Porcaro, AB, Porpiglia, F, Pugliese, D, Pycha, A, Raguso, G, Rampini, A, Randone Donato, F, Roboldi, V, Roscigno, M, Ruggieri, MP, Ruoppo, G, Sanseverino, R, Santacaterina, A, Santarsieri, M, Santoni, R, Scagliarini, S, Scagliotti Giorgio, V, Scanzi, M, Scarcia, M, Schiavina, R, Sciarra, A, Sciorio, C, Scolaro, T, Scuzzarella, S, Selvaggio, O, Serao, A, Serni, S, Signor, MA, Silvani, M, Silvano, G, Silvestris, F, Simone, V, Spagnoletti, G, Spinelli Matteo, G, Squillace, L, Tombolini, V, Toninelli, M, Trinchieri, A, Trodella, LE, Trodella, L, Trombetta, C, Tronnolone, L, Tucci, M, Urzì, D, Valdagni, R, Valeriani, M, Vanoli, M, Vitali, E, Volpe, A, Zaramella, S, Zeccolini, G & Zini, G 2019, 'Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy: A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study)', Urologia Internationalis, vol. 103, n. 1, pagg. 8-18. https://doi.org/10.1159/000496980

Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy: A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study). / Antonelli, Alessandro; Palumbo, Carlotta; Noale, Marianna et al.
In: Urologia Internationalis, Vol. 103, N. 1, 01.07.2019, pag. 8-18.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy

T2 - A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study)

AU - Antonelli, Alessandro

AU - Palumbo, Carlotta

AU - Noale, Marianna

AU - Porreca, Angelo

AU - Maggi, Stefania

AU - Simeone, Claudio

AU - Bassi, Pierfrancesco

AU - Bertoni, Filippo

AU - Bracarda, Sergio

AU - Buglione, Michela

AU - Conti, Giario Natale

AU - Corvò, Renzo

AU - Gacci, Mauro

AU - Mirone, Vincenzo

AU - Montironi, Rodolfo

AU - Triggiani, Luca

AU - Tubaro, Andrea

AU - Artibani, Walter

AU - Crepaldi, Gaetano

AU - Graziotti, Pierpaolo

AU - Russi, Elvio

AU - Magrini Stefano, Maria

AU - Muto, Giovanni

AU - Pecoraro, Stefano

AU - Ricardi, Umberto

AU - Zagonel, Vittorina

AU - Alitto Anna, Rita

AU - Ambrosi, Enrica

AU - Aristei, Cynthia

AU - Barbieri, Michele

AU - Bardari, Franco

AU - Bardoscia, Lilia

AU - Barra, Salvina

AU - Bartoncini, Sara

AU - Basso, Umberto

AU - Becherini, Carlotta

AU - Bellavita, Rita

AU - Bergamaschi, Franco

AU - Berlingheri, Stefania

AU - Berruti, Alfredo

AU - Borghesi, Marco

AU - Bortolus, Roberto

AU - Borzillo, Valentina

AU - Bosetti, Davide

AU - Bove, Giuseppe

AU - Bove, Pierluigi

AU - Brausi, Maurizio

AU - Bruni, Alessio

AU - Bruno, Giorgio

AU - Brunocilla, Eugenio

AU - Buffoli, Alberto

AU - Buttigliero, Consuelo

AU - Cacciamani, Giovanni

AU - Caldiroli, Michela

AU - Cardo, Giuseppe

AU - Carmignani, Giorgio

AU - Carrieri, Giuseppe

AU - Castelli, Emanuele

AU - Castrezzati, Elisabetta

AU - Catalano, Gianpiero

AU - Cattarino, Susanna

AU - Catucci, Francesco

AU - Cavallini, Francolini Dario

AU - Ceccarini, Ofelia

AU - Celia, Antonio

AU - Chiancone, Francesco

AU - Chini, Tommaso

AU - Cianci, Claudia

AU - Cisternino, Antonio

AU - Collura, Devis

AU - Corbella, Franco

AU - Corinti, Matteo

AU - Corsi, Paolo

AU - Cortese, Fiorenza

AU - Corti, Luigi

AU - de Cosimo, Nunzio

AU - Cristiano, Olga

AU - D'Angelillo, Rolando

AU - Da Pozzo, Luigi

AU - D'agostino, Daniele

AU - D'Elia, Carolina

AU - Dandrea, Matteo

AU - De Angelis, De Michele

AU - De Angelis, Paolo

AU - De Cobelli, Ottavio

AU - De Concilio, Bernardino

AU - De Lisa, Antonello

AU - De Luca, Stefano

AU - De Stefani, Agostina

AU - Deantoni, Chiara Lucrezia

AU - Degli Esposti, Claudio

AU - Destito, Anna

AU - Detti, Beatrice

AU - Di Muzio, Nadia

AU - Di Stasio, Andrea

AU - Di Stefano, Calogero

AU - Di Trapani, Danilo

AU - Difino, Giuseppe

AU - Falivene, Sara

AU - Farullo, Giuseppe

AU - Fedelini, Paolo

AU - Ferrari, Ilaria

AU - Ferraù, Francesco

AU - Ferro, Matteo

AU - Fodor, Andrei

AU - Fontana, Francesco

AU - Francesca, Francesco

AU - Francolini, Giulio

AU - Frata, Paolo

AU - Frezza, Giovanni

AU - Gabriele, Pietro

AU - Galeandro, Maria

AU - Garibaldi, Elisabetta

AU - Gennari Pietro, Giovanni

AU - Gentilucci, Alessandro

AU - Giacobbe, Alessandro

AU - Giussani, Laura

AU - Giusti, Giuseppe

AU - Gontero, Paolo

AU - Guarneri, Alessia

AU - Guida, Cesare

AU - Gurioli, Alberto

AU - Huqi, Dorijan

AU - Imbimbo, Ciro

AU - Ingrosso, Gianluca

AU - Iotti, Cinzia

AU - Italia, Corrado

AU - La Mattina, Pierdaniele

AU - Lamanna, Enza

AU - Lastrucci, Luciana

AU - Lazzari, Grazia

AU - Liberale, Fabiola

AU - Liguori, Giovanni

AU - Lisi, Roberto

AU - Lohr, Frank

AU - Lombardo, Riccardo

AU - Lovisolo, Jon A.J.

AU - Ludovico Giuseppe, Mario

AU - Macchione, Nicola

AU - Maggio, Francesca

AU - Malizia, Michele

AU - Manasse, Gianluca

AU - Mandoliti, Giovanni

AU - Mantini, Giovanna

AU - Marafioti, Luigi

AU - Marciello, Luisa

AU - Marconi Alberto, Mario

AU - Martilotta, Antonietta

AU - Marzano, Salvino

AU - Masciullo, Stefano

AU - Maso, Gloria

AU - Massenzo, Adele

AU - Mazzeo, Ercole

AU - Mearini, Luigi

AU - Medoro, Serena

AU - Molè, Rosa

AU - Monesi, Giorgio

AU - Montanari, Emanuele

AU - Montefiore, Franco

AU - Montesi, Giampaolo

AU - Morgia, Giuseppe

AU - Moro, Gregorio

AU - Muscas, Giorgio

AU - Musio, Daniela

AU - Muto, Paolo

AU - Muzzonigro, Giovanni

AU - Napodano, Giorgio

AU - Negro, Carlo Luigi Augusto

AU - Nidini, Mattia

AU - Ntreta, Maria

AU - Orsatti, Marco

AU - Palazzolo, Carmela

AU - Palumbo, Isabella

AU - Parisi, Alessandro

AU - Parma, Paolo

AU - Pavan, Nicola

AU - Pericolini, Martina

AU - Pinto, Francesco

AU - Pistone, Antonio

AU - Pizzuti, Valerio

AU - Platania, Angelo

AU - Polli, Caterina

AU - Pomara, Giorgio

AU - Ponti, Elisabetta

AU - Porcaro, Antonio Benito

AU - Porpiglia, Francesco

AU - Pugliese, Dario

AU - Pycha, Armin

AU - Raguso, Giuseppe

AU - Rampini, Andrea

AU - Randone Donato, Franco

AU - Roboldi, Valentina

AU - Roscigno, Marco

AU - Ruggieri, Maria Paola

AU - Ruoppo, Giuseppe

AU - Sanseverino, Roberto

AU - Santacaterina, Anna

AU - Santarsieri, Michele

AU - Santoni, Riccardo

AU - Scagliarini, Sarah

AU - Scagliotti Giorgio, Vittorio

AU - Scanzi, Mauro

AU - Scarcia, Marcello

AU - Schiavina, Riccardo

AU - Sciarra, Alessandro

AU - Sciorio, Carmine

AU - Scolaro, Tindaro

AU - Scuzzarella, Salvatore

AU - Selvaggio, Oscar

AU - Serao, Armando

AU - Serni, Sergio

AU - Signor, Marco Andrea

AU - Silvani, Mauro

AU - Silvano, Giovanni

AU - Silvestris, Franco

AU - Simone, Valeria

AU - Spagnoletti, Girolamo

AU - Spinelli Matteo, Giulio

AU - Squillace, Luigi

AU - Tombolini, Vincenzo

AU - Toninelli, Mariastella

AU - Trinchieri, Alberto

AU - Trodella, Luca Eolo

AU - Trodella, Lucio

AU - Trombetta, Carlo

AU - Tronnolone, Lidia

AU - Tucci, Marcello

AU - Urzì, Daniele

AU - Valdagni, Riccardo

AU - Valeriani, Maurizio

AU - Vanoli, Maurizio

AU - Vitali, Elisabetta

AU - Volpe, Alessandro

AU - Zaramella, Stefano

AU - Zeccolini, Guglielmo

AU - Zini, Giampaolo

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background: To report health-related quality of life outcomes as assessed by validated patient-reported outcome measures (PROMs) after radical prostatectomy (RP).-Methods: This study analyzed patients treated with RP within The PROState cancer monitoring in Italy, from the National Research Council (Pros-IT CNR). Italian versions of Short-Form Heath Survey and university of California los Angeles-prostate cancer index questionnaires were administered. PROMs were physical composite scores, mental composite scores and urinary, bowel, sexual functions and bothers (UF/B, BF/B, SF/B). Baseline unbalances were controlled with propensity scores and stabilized inverse weights; differences in PROMs between different RP approaches were estimated by mixed models. Results: Of 541 patients treated with RP, 115 (21%) received open RP (ORP), 90 (17%) laparoscopic RP (LRP) and 336 (61%) robot-assisted RP (RARP). At head-to-head-comparisons, RARP showed higher 12-month UF vs. LRP (interaction treatment ∗ time p = 0.03) and 6-month SF vs. ORP (p < 0.001). At 12-month from surgery, 67, 73 and 79% of patients used no pad for urinary loss in ORP, LRP and RARP respectively (no differences for each comparison). Conversely, 16, 27 and 40% of patients declared erections firm enough for sexual intercourse in ORP, LRP and RARP respectively (only significant difference for ORP vs. RARP, p = 0.0004). Conclusions: Different RP approaches lead to significant variations in urinary and sexual PROMs, with a general trend in favour of RARP. However, their clinical significance seems limited.

AB - Background: To report health-related quality of life outcomes as assessed by validated patient-reported outcome measures (PROMs) after radical prostatectomy (RP).-Methods: This study analyzed patients treated with RP within The PROState cancer monitoring in Italy, from the National Research Council (Pros-IT CNR). Italian versions of Short-Form Heath Survey and university of California los Angeles-prostate cancer index questionnaires were administered. PROMs were physical composite scores, mental composite scores and urinary, bowel, sexual functions and bothers (UF/B, BF/B, SF/B). Baseline unbalances were controlled with propensity scores and stabilized inverse weights; differences in PROMs between different RP approaches were estimated by mixed models. Results: Of 541 patients treated with RP, 115 (21%) received open RP (ORP), 90 (17%) laparoscopic RP (LRP) and 336 (61%) robot-assisted RP (RARP). At head-to-head-comparisons, RARP showed higher 12-month UF vs. LRP (interaction treatment ∗ time p = 0.03) and 6-month SF vs. ORP (p < 0.001). At 12-month from surgery, 67, 73 and 79% of patients used no pad for urinary loss in ORP, LRP and RARP respectively (no differences for each comparison). Conversely, 16, 27 and 40% of patients declared erections firm enough for sexual intercourse in ORP, LRP and RARP respectively (only significant difference for ORP vs. RARP, p = 0.0004). Conclusions: Different RP approaches lead to significant variations in urinary and sexual PROMs, with a general trend in favour of RARP. However, their clinical significance seems limited.

KW - Patient-reported outcome measures

KW - Prostate cancer

KW - Quality of life

KW - Radical prostatectomy

KW - Sexual function

KW - Urinary function

UR - http://www.scopus.com/inward/record.url?scp=85061307706&partnerID=8YFLogxK

U2 - 10.1159/000496980

DO - 10.1159/000496980

M3 - Article

SN - 0042-1138

VL - 103

SP - 8

EP - 18

JO - Urologia Internationalis

JF - Urologia Internationalis

IS - 1

ER -

Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy: A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study)

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