Impact of recipient ACE I/D genotype on kidney function in renal transplant patients: A meta-analysis of cross-sectional and longitudinal studies

Sarah Cargnin, Marco Quaglia, Pier Luigi Canonico, Piero Stratta, Salvatore Terrazzino

Risultato della ricerca: Contributo su rivistaArticolo di reviewpeer review

Abstract

Aim: To perform a systematic review and meta-analysis of studies evaluating the influence of recipient angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism on kidney function in renal transplant recipients. Materials & methods: A comprehensive search was performed through PubMed, Web of Knowledge and Cochrane databases up to December 2014. The methodological quality of identified studies was assessed using the MINORS criteria. Results: A total of 15 studies evaluating the role of recipient ACE I/D were included in the meta-analysis. In overall analyzes and subsequent subgroup and sensitivity analyzes, no evidence emerged of an effect of ACE I/D on serum creatinine levels, creatinine clearance or glomerular filtration rate. Conclusion: Although further investigation is still needed to determine the role of donor ACE genotype, recipient ACE I/D does not play a significant role on kidney function in renal transplant patients.

Lingua originaleInglese
pagine (da-a)1887-1902
Numero di pagine16
RivistaPharmacogenomics
Volume16
Numero di pubblicazione16
DOI
Stato di pubblicazionePubblicato - nov 2015

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