Immunophenotypic characterization of IgVH3-72 B-cell chronic lymphocytic leukaemia (B-CLL)

Daniela Capello; Antonella Zucchetto; Massimo Degan; Riccardo Bomben; Michele Dal Bo; Dimitar G. Efremov; Luca Laurenti; Giovanni Del Poeta; Gianluca Gaidano; Valter Gattei

doi:10.1016/j.leukres.2005.11.019

Immunophenotypic characterization of IgV_H3-72 B-cell chronic lymphocytic leukaemia (B-CLL)

Daniela Capello
, Antonella Zucchetto
, Massimo Degan
, Riccardo Bomben
, Michele Dal Bo
, Dimitar G. Efremov
, Luca Laurenti
, Giovanni Del Poeta
, Gianluca Gaidano
, Valter Gattei

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The frequent expression of the otherwise rare IgV_H3-72 gene was demonstrated in highly stable B-cell chronic lymphocytic leukaemias (B-CLLs). Here we describe the immunophenotypic profiles of eleven IgV_H3-72 B-CLLs, by investigating expression of ZAP-70 and of a set of surface antigens previously demonstrated to represent the signature of distinct B-CLL prognostic groups. All IgV_H3-72 B-CLLs revealed a homogeneous immunophenotypic profile, expressing all the markers associated with good prognosis, but not those representing the signature of bad prognosis B-CLLs, including ZAP-70. Our results corroborate the notion that IgV_H3-72 B-CLLs represent a molecularly and immunophenotypically homogeneous disease group with a good prognosis.

Lingua originale	Inglese
pagine (da-a)	1197-1199
Numero di pagine	3
Rivista	Leukemia Research
Volume	30
Numero di pubblicazione	9
DOI	https://doi.org/10.1016/j.leukres.2005.11.019
Stato di pubblicazione	Pubblicato - set 2006

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

SDG 3 Salute e benessere

Accesso al documento

10.1016/j.leukres.2005.11.019

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{1f542e1c12b04f36968bb4aa51719164,

title = "Immunophenotypic characterization of IgVH3-72 B-cell chronic lymphocytic leukaemia (B-CLL)",

abstract = "The frequent expression of the otherwise rare IgVH3-72 gene was demonstrated in highly stable B-cell chronic lymphocytic leukaemias (B-CLLs). Here we describe the immunophenotypic profiles of eleven IgVH3-72 B-CLLs, by investigating expression of ZAP-70 and of a set of surface antigens previously demonstrated to represent the signature of distinct B-CLL prognostic groups. All IgVH3-72 B-CLLs revealed a homogeneous immunophenotypic profile, expressing all the markers associated with good prognosis, but not those representing the signature of bad prognosis B-CLLs, including ZAP-70. Our results corroborate the notion that IgVH3-72 B-CLLs represent a molecularly and immunophenotypically homogeneous disease group with a good prognosis.",

keywords = "CLL, Prognosis, Immunophenotype",

author = "Daniela Capello and Antonella Zucchetto and Massimo Degan and Riccardo Bomben and Bo, \{Michele Dal\} and Efremov, \{Dimitar G.\} and Luca Laurenti and Poeta, \{Giovanni Del\} and Gianluca Gaidano and Valter Gattei",

year = "2006",

month = sep,

doi = "10.1016/j.leukres.2005.11.019",

language = "English",

volume = "30",

pages = "1197--1199",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd.",

number = "9",

}

TY - JOUR

T1 - Immunophenotypic characterization of IgVH3-72 B-cell chronic lymphocytic leukaemia (B-CLL)

AU - Capello, Daniela

AU - Zucchetto, Antonella

AU - Degan, Massimo

AU - Bomben, Riccardo

AU - Bo, Michele Dal

AU - Efremov, Dimitar G.

AU - Laurenti, Luca

AU - Poeta, Giovanni Del

AU - Gaidano, Gianluca

AU - Gattei, Valter

PY - 2006/9

Y1 - 2006/9

N2 - The frequent expression of the otherwise rare IgVH3-72 gene was demonstrated in highly stable B-cell chronic lymphocytic leukaemias (B-CLLs). Here we describe the immunophenotypic profiles of eleven IgVH3-72 B-CLLs, by investigating expression of ZAP-70 and of a set of surface antigens previously demonstrated to represent the signature of distinct B-CLL prognostic groups. All IgVH3-72 B-CLLs revealed a homogeneous immunophenotypic profile, expressing all the markers associated with good prognosis, but not those representing the signature of bad prognosis B-CLLs, including ZAP-70. Our results corroborate the notion that IgVH3-72 B-CLLs represent a molecularly and immunophenotypically homogeneous disease group with a good prognosis.

AB - The frequent expression of the otherwise rare IgVH3-72 gene was demonstrated in highly stable B-cell chronic lymphocytic leukaemias (B-CLLs). Here we describe the immunophenotypic profiles of eleven IgVH3-72 B-CLLs, by investigating expression of ZAP-70 and of a set of surface antigens previously demonstrated to represent the signature of distinct B-CLL prognostic groups. All IgVH3-72 B-CLLs revealed a homogeneous immunophenotypic profile, expressing all the markers associated with good prognosis, but not those representing the signature of bad prognosis B-CLLs, including ZAP-70. Our results corroborate the notion that IgVH3-72 B-CLLs represent a molecularly and immunophenotypically homogeneous disease group with a good prognosis.

KW - CLL, Prognosis, Immunophenotype

UR - https://www.scopus.com/pages/publications/33745824962

U2 - 10.1016/j.leukres.2005.11.019

DO - 10.1016/j.leukres.2005.11.019

M3 - Article

SN - 0145-2126

VL - 30

SP - 1197

EP - 1199

JO - Leukemia Research

JF - Leukemia Research

IS - 9

ER -