TY - JOUR
T1 - Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells
AU - Fallarini, Silvia
AU - Brittoli, Alvaro
AU - Fiore, Michele
AU - Lombardi, Grazia
AU - Renaudet, Olivier
AU - Richichi, Barbara
AU - Nativi, Cristina
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - The ability of a rigid α-Tn mimetic (compound 1) to activate murine invariant natural killer T (iNKT) and human natural killer (NK) cells, two subsets of lymphocytes involved in cancer immunesurveillance, was investigated. For this purpose, the mimetic 1 was properly conjugated to a stearic acid containing glycerol-based phospholipid (compound 5) to be presented, in the context of the conserved non polymorphic major histocompatibility complex class I-like molecules (CD1d), to iNKT cells. On the contrary, the mimetic 1 was conjugated to a multivalent peptide-based scaffold (compound 6) to induce NK cell activation.
AB - The ability of a rigid α-Tn mimetic (compound 1) to activate murine invariant natural killer T (iNKT) and human natural killer (NK) cells, two subsets of lymphocytes involved in cancer immunesurveillance, was investigated. For this purpose, the mimetic 1 was properly conjugated to a stearic acid containing glycerol-based phospholipid (compound 5) to be presented, in the context of the conserved non polymorphic major histocompatibility complex class I-like molecules (CD1d), to iNKT cells. On the contrary, the mimetic 1 was conjugated to a multivalent peptide-based scaffold (compound 6) to induce NK cell activation.
KW - Glycomimetic
KW - Immunotherapy
KW - Invariant natural killer T cells
KW - Natural killer cells
KW - α-Tn antigen
UR - http://www.scopus.com/inward/record.url?scp=85020119446&partnerID=8YFLogxK
U2 - 10.1007/s10719-017-9775-6
DO - 10.1007/s10719-017-9775-6
M3 - Article
SN - 0282-0080
VL - 34
SP - 553
EP - 562
JO - Glycoconjugate Journal
JF - Glycoconjugate Journal
IS - 4
ER -
