Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c-MET) in human brain tissues

T. Yamada; H. Tsubouchi; Y. Daikuhara; M. Prat; P. M. Comoglio; P. L. McGeer; E. G. McGeer

doi:10.1016/0006-8993(94)91250-5

Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c-MET) in human brain tissues

T. Yamada, H. Tsubouchi, Y. Daikuhara, M. Prat, P. M. Comoglio, P. L. McGeer, E. G. McGeer

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and also has multifunctional effects on some other cells in various organs. The human c-Met proto-oncogene product has recently been identified as its high-affinity receptor. We examined HGF-like and c-Met protein-like immunoreactivities in the brains of neurologically normal, lacunar stroke and Alzheimer disease (AD) cases. The HGF antibody stained only round cells in the capillaries and astrocytes in the white matter. Positive staining with the antibody to c-Met protein was seen in microglia, predominantly in the white matter. The possibility of interactions between astrocytes and microglia through HGF and its receptor is suggested.

Lingua originale	Inglese
pagine (da-a)	308-312
Numero di pagine	5
Rivista	Brain Research
Volume	637
Numero di pubblicazione	1-2
DOI	https://doi.org/10.1016/0006-8993(94)91250-5
Stato di pubblicazione	Pubblicato - 21 feb 1994
Pubblicato esternamente	Sì

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@article{17ac33b625e04bf988f61dfc234dcc5a,

title = "Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c-MET) in human brain tissues",

abstract = "Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and also has multifunctional effects on some other cells in various organs. The human c-Met proto-oncogene product has recently been identified as its high-affinity receptor. We examined HGF-like and c-Met protein-like immunoreactivities in the brains of neurologically normal, lacunar stroke and Alzheimer disease (AD) cases. The HGF antibody stained only round cells in the capillaries and astrocytes in the white matter. Positive staining with the antibody to c-Met protein was seen in microglia, predominantly in the white matter. The possibility of interactions between astrocytes and microglia through HGF and its receptor is suggested.",

keywords = "Alzheimer's disease, Astrocyte, Hepatocytes growth factor, Microglia, c-Met protein",

author = "T. Yamada and H. Tsubouchi and Y. Daikuhara and M. Prat and Comoglio, {P. M.} and McGeer, {P. L.} and McGeer, {E. G.}",

note = "Funding Information: This research was supported by grants from the the Alzheimer Society of B.C., as well as donations from individual British Columbmns.",

year = "1994",

month = feb,

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doi = "10.1016/0006-8993(94)91250-5",

language = "English",

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TY - JOUR

T1 - Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c-MET) in human brain tissues

AU - Yamada, T.

AU - Tsubouchi, H.

AU - Daikuhara, Y.

AU - Prat, M.

AU - Comoglio, P. M.

AU - McGeer, P. L.

AU - McGeer, E. G.

N1 - Funding Information: This research was supported by grants from the the Alzheimer Society of B.C., as well as donations from individual British Columbmns.

PY - 1994/2/21

Y1 - 1994/2/21

N2 - Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and also has multifunctional effects on some other cells in various organs. The human c-Met proto-oncogene product has recently been identified as its high-affinity receptor. We examined HGF-like and c-Met protein-like immunoreactivities in the brains of neurologically normal, lacunar stroke and Alzheimer disease (AD) cases. The HGF antibody stained only round cells in the capillaries and astrocytes in the white matter. Positive staining with the antibody to c-Met protein was seen in microglia, predominantly in the white matter. The possibility of interactions between astrocytes and microglia through HGF and its receptor is suggested.

AB - Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes, and also has multifunctional effects on some other cells in various organs. The human c-Met proto-oncogene product has recently been identified as its high-affinity receptor. We examined HGF-like and c-Met protein-like immunoreactivities in the brains of neurologically normal, lacunar stroke and Alzheimer disease (AD) cases. The HGF antibody stained only round cells in the capillaries and astrocytes in the white matter. Positive staining with the antibody to c-Met protein was seen in microglia, predominantly in the white matter. The possibility of interactions between astrocytes and microglia through HGF and its receptor is suggested.

KW - Alzheimer's disease

KW - Astrocyte

KW - Hepatocytes growth factor

KW - Microglia

KW - c-Met protein

UR - http://www.scopus.com/inward/record.url?scp=0028079544&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(94)91250-5

DO - 10.1016/0006-8993(94)91250-5

M3 - Article

SN - 0006-8993

VL - 637

SP - 308

EP - 312

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c-MET) in human brain tissues

Abstract

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