Immunogenetics features and genomic lesions in splenic marginal zone lymphoma

Andrea Rinaldi; Francesco Forconi; Luca Arcaini; Michael Mian; Elena Sozzi; Silvia Zibellini; Luca Baldini; Silvia Franceschetti; Gianluca Gaidano; Roberto Marasca; Manuela Mollejo; Miguel A. Piris; Alessandra Tucci; Fabio Facchetti; Govind Bhagat; Riccardo D. Favera; Paola M.V. Rancoita; Emanuele Zucca; Ivo Kwee; Francesco Bertoni

doi:10.1111/j.1365-2141.2010.08347.x

Immunogenetics features and genomic lesions in splenic marginal zone lymphoma

Andrea Rinaldi, Francesco Forconi, Luca Arcaini, Michael Mian, Elena Sozzi, Silvia Zibellini, Luca Baldini, Silvia Franceschetti, Gianluca Gaidano, Roberto Marasca, Manuela Mollejo, Miguel A. Piris, Alessandra Tucci, Fabio Facchetti, Govind Bhagat, Riccardo D. Favera, Paola M.V. Rancoita, Emanuele Zucca, Ivo Kwee, Francesco Bertoni

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Splenic marginal zone lymphomas (MZL) express mutated (M-) or unmutated (U-) immunoglobulin heavy chain (IGHV) genes. To investigate the IGHV mutational status impact on genetic lesions, this study combined single nucleotide polymorphism-arrays and IGHV sequencing in 83 cases. Clinical features and outcome were similar between U- and M-IGHV cases. Recurrent lesions frequency was higher in U-IGHV cases, including poor prognosticators. Frequencies differed among cases bearing individual IGHV genes or lambda light chains. In conclusion, SMZL comprises subgroups based on genetic abnormalities and immunogenetic status. Genomic lesion frequency differed and was higher in U-IGHV cases, possibly affecting the outcome.

Lingua originale	Inglese
pagine (da-a)	435-439
Numero di pagine	5
Rivista	British Journal of Haematology
Volume	151
Numero di pubblicazione	5
DOI	https://doi.org/10.1111/j.1365-2141.2010.08347.x
Stato di pubblicazione	Pubblicato - dic 2010

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10.1111/j.1365-2141.2010.08347.x

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Rinaldi, A., Forconi, F., Arcaini, L., Mian, M., Sozzi, E., Zibellini, S., Baldini, L., Franceschetti, S., Gaidano, G., Marasca, R., Mollejo, M., Piris, M. A., Tucci, A., Facchetti, F., Bhagat, G., Favera, R. D., Rancoita, P. M. V., Zucca, E., Kwee, I., & Bertoni, F. (2010). Immunogenetics features and genomic lesions in splenic marginal zone lymphoma. British Journal of Haematology, 151(5), 435-439. https://doi.org/10.1111/j.1365-2141.2010.08347.x

@article{cedebaf7257545beabc0185ea40d3705,

title = "Immunogenetics features and genomic lesions in splenic marginal zone lymphoma",

abstract = "Splenic marginal zone lymphomas (MZL) express mutated (M-) or unmutated (U-) immunoglobulin heavy chain (IGHV) genes. To investigate the IGHV mutational status impact on genetic lesions, this study combined single nucleotide polymorphism-arrays and IGHV sequencing in 83 cases. Clinical features and outcome were similar between U- and M-IGHV cases. Recurrent lesions frequency was higher in U-IGHV cases, including poor prognosticators. Frequencies differed among cases bearing individual IGHV genes or lambda light chains. In conclusion, SMZL comprises subgroups based on genetic abnormalities and immunogenetic status. Genomic lesion frequency differed and was higher in U-IGHV cases, possibly affecting the outcome.",

keywords = "CGH, Immunogenetics, Immunoglobulin genes, Lymphomas, Microarray, Spleen",

author = "Andrea Rinaldi and Francesco Forconi and Luca Arcaini and Michael Mian and Elena Sozzi and Silvia Zibellini and Luca Baldini and Silvia Franceschetti and Gianluca Gaidano and Roberto Marasca and Manuela Mollejo and Piris, {Miguel A.} and Alessandra Tucci and Fabio Facchetti and Govind Bhagat and Favera, {Riccardo D.} and Rancoita, {Paola M.V.} and Emanuele Zucca and Ivo Kwee and Francesco Bertoni",

year = "2010",

month = dec,

doi = "10.1111/j.1365-2141.2010.08347.x",

language = "English",

volume = "151",

pages = "435--439",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley and Sons Inc.",

number = "5",

}

Rinaldi, A, Forconi, F, Arcaini, L, Mian, M, Sozzi, E, Zibellini, S, Baldini, L, Franceschetti, S, Gaidano, G, Marasca, R, Mollejo, M, Piris, MA, Tucci, A, Facchetti, F, Bhagat, G, Favera, RD, Rancoita, PMV, Zucca, E, Kwee, I & Bertoni, F 2010, 'Immunogenetics features and genomic lesions in splenic marginal zone lymphoma', British Journal of Haematology, vol. 151, n. 5, pagg. 435-439. https://doi.org/10.1111/j.1365-2141.2010.08347.x

TY - JOUR

T1 - Immunogenetics features and genomic lesions in splenic marginal zone lymphoma

AU - Rinaldi, Andrea

AU - Forconi, Francesco

AU - Arcaini, Luca

AU - Mian, Michael

AU - Sozzi, Elena

AU - Zibellini, Silvia

AU - Baldini, Luca

AU - Franceschetti, Silvia

AU - Gaidano, Gianluca

AU - Marasca, Roberto

AU - Mollejo, Manuela

AU - Piris, Miguel A.

AU - Tucci, Alessandra

AU - Facchetti, Fabio

AU - Bhagat, Govind

AU - Favera, Riccardo D.

AU - Rancoita, Paola M.V.

AU - Zucca, Emanuele

AU - Kwee, Ivo

AU - Bertoni, Francesco

PY - 2010/12

Y1 - 2010/12

N2 - Splenic marginal zone lymphomas (MZL) express mutated (M-) or unmutated (U-) immunoglobulin heavy chain (IGHV) genes. To investigate the IGHV mutational status impact on genetic lesions, this study combined single nucleotide polymorphism-arrays and IGHV sequencing in 83 cases. Clinical features and outcome were similar between U- and M-IGHV cases. Recurrent lesions frequency was higher in U-IGHV cases, including poor prognosticators. Frequencies differed among cases bearing individual IGHV genes or lambda light chains. In conclusion, SMZL comprises subgroups based on genetic abnormalities and immunogenetic status. Genomic lesion frequency differed and was higher in U-IGHV cases, possibly affecting the outcome.

AB - Splenic marginal zone lymphomas (MZL) express mutated (M-) or unmutated (U-) immunoglobulin heavy chain (IGHV) genes. To investigate the IGHV mutational status impact on genetic lesions, this study combined single nucleotide polymorphism-arrays and IGHV sequencing in 83 cases. Clinical features and outcome were similar between U- and M-IGHV cases. Recurrent lesions frequency was higher in U-IGHV cases, including poor prognosticators. Frequencies differed among cases bearing individual IGHV genes or lambda light chains. In conclusion, SMZL comprises subgroups based on genetic abnormalities and immunogenetic status. Genomic lesion frequency differed and was higher in U-IGHV cases, possibly affecting the outcome.

KW - CGH

KW - Immunogenetics

KW - Immunoglobulin genes

KW - Lymphomas

KW - Microarray

KW - Spleen

UR - http://www.scopus.com/inward/record.url?scp=78349301947&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.2010.08347.x

DO - 10.1111/j.1365-2141.2010.08347.x

M3 - Article

SN - 0007-1048

VL - 151

SP - 435

EP - 439

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 5

ER -

Immunogenetics features and genomic lesions in splenic marginal zone lymphoma

Abstract

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