Identification of a Strigoterpenoid with Dual Nrf2 and Nf-Î°B Modulatory Activity

Federica Rogati; Estrella Millán; Giovanni Appendino; Alejandro Correa; Diego Caprioglio; Alberto Minassi; Eduardo Munoz

doi:10.1021/acsmedchemlett.8b00604

Identification of a Strigoterpenoid with Dual Nrf2 and Nf-Î°B Modulatory Activity

Federica Rogati
, Estrella Millán
, Giovanni Appendino
, Alejandro Correa
, Diego Caprioglio
, Alberto Minassi
, Eduardo Munoz

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.

Lingua originale	Inglese
pagine (da-a)	606-610
Numero di pagine	5
Rivista	ACS Medicinal Chemistry Letters
Volume	10
Numero di pubblicazione	4
DOI	https://doi.org/10.1021/acsmedchemlett.8b00604
Stato di pubblicazione	Pubblicato - 11 apr 2019

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10.1021/acsmedchemlett.8b00604

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title = "Identification of a Strigoterpenoid with Dual Nrf2 and Nf-{\^I}°B Modulatory Activity",

abstract = "The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.",

keywords = "NF-B, Nrf2, Strigolactones, terpenes",

author = "Federica Rogati and Estrella Mill{\'a}n and Giovanni Appendino and Alejandro Correa and Diego Caprioglio and Alberto Minassi and Eduardo Munoz",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

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doi = "10.1021/acsmedchemlett.8b00604",

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AU - Rogati, Federica

AU - Millán, Estrella

AU - Appendino, Giovanni

AU - Correa, Alejandro

AU - Caprioglio, Diego

AU - Minassi, Alberto

AU - Munoz, Eduardo

PY - 2019/4/11

Y1 - 2019/4/11

N2 - The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.

AB - The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.

KW - NF-B

KW - Nrf2

KW - Strigolactones

KW - terpenes

UR - https://www.scopus.com/pages/publications/85060008254

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DO - 10.1021/acsmedchemlett.8b00604

M3 - Article

SN - 1948-5875

VL - 10

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EP - 610

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

IS - 4

ER -

Identification of a Strigoterpenoid with Dual Nrf2 and Nf-Î°B Modulatory Activity

Abstract

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