@article{0862ea680fa243a880f6a9c073c0e72d,
title = "Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2",
abstract = "As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogues of nicotinamide. Biological data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2.",
keywords = "Histone deacetylase, Isostere, N-Unsubstituted-1,2, 3-triazolyl pyridine, Rigid analogues, Sirtuins",
author = "Ubaldina Galli and Ornella Mesenzani and Camilla Coppo and Giovanni Sorba and Canonico, \{Pier Luigi\} and Tron, \{Gian Cesare\} and Genazzani, \{Armando A.\}",
note = "Funding Information: Financial support from Universit{\`a} del Piemonte Orientale and AIRC ( IG10509 )",
year = "2012",
month = sep,
doi = "10.1016/j.ejmech.2012.07.001",
language = "English",
volume = "55",
pages = "58--66",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier Masson s.r.l.",
}