Identification of a novel NAMPT inhibitor by combinatorial click chemistry and chemical refinement

Keyphrases

• Click Chemistry 100%
• NAMPT Inhibitor 100%
• Cancer Cells 50%
• Antitumoral 50%
• Alkynes 50%
• Cytotoxicity 50%
• Cycloaddition 50%
• Azides 50%
• Triazole 50%
• Anti-inflammatory Drugs 50%
• Nicotinamide Phosphoribosyltransferase (NAMPT) 50%
• Neuroblastoma Cancer 50%
• Hit Compound 50%
• NAD Salvage 50%
• Copper-catalyzed 50%

Chemistry

• Click Chemistry 100%
• Azide 50%
• Anti-Inflammatory Drug 50%
• Alkyne 50%
• Cycloaddition 50%
• Triazole 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Nicotinamide Phosphoribosyltransferase 100%
• Malignant Neoplasm 33%
• Alkyne 33%
• Neuroblastoma 33%
• Antiinflammatory Agent 33%
• Azide 33%
• Cytotoxicity 33%
• Triazole 33%