Identification of a Compound Inhibiting Both the Enzymatic and Nonenzymatic Functions of Indoleamine 2,3-Dioxygenase 1

Keyphrases

• Indoleamine 2,3-dioxygenase 1 (IDO1) 100%
• Enzymatic Function 100%
• Non-enzymatic Function 100%
• Enzymatic Activity 42%
• Phosphoinositide 3-kinase (PI3K) 28%
• Regulatory Subunit 28%
• Protein Tyrosine Phosphatase 1B (PTP1B) 28%
• Indoleamine 2,3-dioxygenase 1 Inhibitor 28%
• In Cancer 14%
• Mechanism of Action 14%
• Small Molecules 14%
• Signaling Pathway 14%
• Tumor Cells 14%
• Monocytes 14%
• Heme 14%
• SH3 Domain 14%
• Dendritic Cells 14%
• Pancreatic Cancer 14%
• Therapeutic Potential 14%
• Signal Transducing 14%
• Virtual Screening 14%
• Metabolic Enzymes 14%
• T Cell Proliferation 14%
• Freeform 14%
• Competitive Advantage 14%
• Tumor Immune Escape 14%
• Cancer Immunotherapy 14%
• Tryptophan Catabolism 14%
• Non-enzymatic Activity 14%
• Apo Form 14%
• Phosphatase Substrate 14%
• Early Endosomes 14%

Immunology and Microbiology

• Indoleamine 2,3-dioxygenase 100%
• Immunosuppressive Drug 22%
• Enzyme Activity 22%
• Tyrosine 22%
• Phosphatase 22%
• Tumor Cell 11%
• Dendritic Cell 11%
• Endosome 11%
• T Cell Proliferation 11%
• Immune Escape 11%
• Cancer Immunotherapy 11%
• Heme 11%
• Tryptophan 11%

Biochemistry, Genetics and Molecular Biology

• Indoleamine 2,3-dioxygenase 100%
• Enzyme Activity 22%
• Phosphoinositide 3-Kinase 22%
• Protein Tyrosine Phosphatase 22%
• Enzyme 11%
• Small Molecule 11%
• Cell Proliferation 11%
• T Cell 11%
• Dendritic Cell 11%
• Cancer Immunotherapy 11%
• Tryptophan 11%