Identification and characterization of a κB/Rel binding site in the regulatory region of the amyloid precursor protein gene

Mariagrazia Grilli, Marina Ribola, Antonella Alberici, Alessandra Valerio, Maurizio Memo, Pier Franco Spano

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Several observations support the hypothesis that pathogenetic mechanisms of β amyloid formation in Alzheimer's disease may involve alterations in amyloid precursor protein (APP) gene expression. In this regard, molecular dissection of the APP gene transcriptional regulation is of primary importance. We report evidence that members of the family of transcription factors NFκB/Rel can specifically recognize two identical sequences located in the 5'-regulatory region of APP. These sequences, which we refer to as APPκB sites, interact preferentially with p50-containing members of the family. In particular, p50 homodimers and p50/p65 and p50/c-Rel heterodimers act as transcriptional activators at the APPκB site. Finally, the nuclear complex specifically binding to the APPκR sites proves to be an integral part of neurons and lymphocytes.

Lingua originaleInglese
pagine (da-a)26774-26777
Numero di pagine4
RivistaJournal of Biological Chemistry
Volume270
Numero di pubblicazione45
DOI
Stato di pubblicazionePubblicato - 10 nov 1995
Pubblicato esternamente

Fingerprint

Entra nei temi di ricerca di 'Identification and characterization of a κB/Rel binding site in the regulatory region of the amyloid precursor protein gene'. Insieme formano una fingerprint unica.

Cita questo