ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution

Luca Castelli; Cristoforo Comi; Annalisa Chiocchetti; Stefania Nicola; Riccardo Mesturini; Mara Giordano; Sandra D'Alfonso; Elisa Cerutti; Daniela Galimberti; Chiara Fenoglio; Fabiana Tesser; Junji Yagi; José Maria Rojo; Franco Perla; Maurizio Leone; Elio Scarpini; Francesco Monaco; Umberto Dianzani

doi:10.1016/j.jneuroim.2007.03.022

ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution

Luca Castelli, Cristoforo Comi, Annalisa Chiocchetti, Stefania Nicola, Riccardo Mesturini, Mara Giordano, Sandra D'Alfonso, Elisa Cerutti, Daniela Galimberti, Chiara Fenoglio, Fabiana Tesser, Junji Yagi, José Maria Rojo, Franco Perla, Maurizio Leone, Elio Scarpini, Francesco Monaco, Umberto Dianzani

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Human ICOS is a T cell costimulatory molecule supporting IL10 secretion. A pilot study investigating variations of the ICOS gene 3'UTR detected 8 polymorphisms forming three haplotypes (A, B, C). Haplotype-A and -C displayed the highest difference. Activated T cells from healthy AA homozygotes expressed significantly less ICOS and secreted more IL10 than AC heterozygotes, whereas AB heterozygotes displayed intermediate levels. Analysis of 441 multiple sclerosis patients and 793 controls showed that frequency of AA homozygosity was significantly lower in MS patients with relapsing-remitting onset (N = 416) than in controls (OR = 0.70). Moreover, AA patients with relapsing-remitting onset had lower relapse rate and multiple sclerosis severity score than non-AA patients.

Lingua originale	Inglese
pagine (da-a)	193-198
Numero di pagine	6
Rivista	Journal of Neuroimmunology
Volume	186
Numero di pubblicazione	1-2
DOI	https://doi.org/10.1016/j.jneuroim.2007.03.022
Stato di pubblicazione	Pubblicato - mag 2007

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10.1016/j.jneuroim.2007.03.022

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Castelli, L., Comi, C., Chiocchetti, A., Nicola, S., Mesturini, R., Giordano, M., D'Alfonso, S., Cerutti, E., Galimberti, D., Fenoglio, C., Tesser, F., Yagi, J., Rojo, J. M., Perla, F., Leone, M., Scarpini, E., Monaco, F., & Dianzani, U. (2007). ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution. Journal of Neuroimmunology, 186(1-2), 193-198. https://doi.org/10.1016/j.jneuroim.2007.03.022

@article{c3c9c7f63bbc4f709d0f8fdeb7f53a43,

title = "ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution",

abstract = "Human ICOS is a T cell costimulatory molecule supporting IL10 secretion. A pilot study investigating variations of the ICOS gene 3'UTR detected 8 polymorphisms forming three haplotypes (A, B, C). Haplotype-A and -C displayed the highest difference. Activated T cells from healthy AA homozygotes expressed significantly less ICOS and secreted more IL10 than AC heterozygotes, whereas AB heterozygotes displayed intermediate levels. Analysis of 441 multiple sclerosis patients and 793 controls showed that frequency of AA homozygosity was significantly lower in MS patients with relapsing-remitting onset (N = 416) than in controls (OR = 0.70). Moreover, AA patients with relapsing-remitting onset had lower relapse rate and multiple sclerosis severity score than non-AA patients.",

keywords = "ICOS, IL10, Multiple sclerosis",

author = "Luca Castelli and Cristoforo Comi and Annalisa Chiocchetti and Stefania Nicola and Riccardo Mesturini and Mara Giordano and Sandra D'Alfonso and Elisa Cerutti and Daniela Galimberti and Chiara Fenoglio and Fabiana Tesser and Junji Yagi and Rojo, {Jos{\'e} Maria} and Franco Perla and Maurizio Leone and Elio Scarpini and Francesco Monaco and Umberto Dianzani",

note = "Funding Information: This work was partially supported by Telethon grant E1170 (Rome), FISM grant 2005/R/10 (Genoa), AIRC (Milan), PRIN Project (MIUR, Rome), Fondazione Cariplo (Milan), Compagnia di San Paolo (Turin), Fondazione Cassa di Risparmio di Cuneo (Cuneo), Regione Piemonte (Turin), and Associazione “Amici di Jean” (Turin).",

year = "2007",

month = may,

doi = "10.1016/j.jneuroim.2007.03.022",

language = "English",

volume = "186",

pages = "193--198",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

number = "1-2",

}

Castelli, L, Comi, C , Chiocchetti, A, Nicola, S, Mesturini, R, Giordano, M , D'Alfonso, S, Cerutti, E, Galimberti, D, Fenoglio, C, Tesser, F, Yagi, J, Rojo, JM, Perla, F, Leone, M, Scarpini, E, Monaco, F & Dianzani, U 2007, 'ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution', Journal of Neuroimmunology, vol. 186, n. 1-2, pagg. 193-198. https://doi.org/10.1016/j.jneuroim.2007.03.022

TY - JOUR

T1 - ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution

AU - Castelli, Luca

AU - Comi, Cristoforo

AU - Chiocchetti, Annalisa

AU - Nicola, Stefania

AU - Mesturini, Riccardo

AU - Giordano, Mara

AU - D'Alfonso, Sandra

AU - Cerutti, Elisa

AU - Galimberti, Daniela

AU - Fenoglio, Chiara

AU - Tesser, Fabiana

AU - Yagi, Junji

AU - Rojo, José Maria

AU - Perla, Franco

AU - Leone, Maurizio

AU - Scarpini, Elio

AU - Monaco, Francesco

AU - Dianzani, Umberto

N1 - Funding Information: This work was partially supported by Telethon grant E1170 (Rome), FISM grant 2005/R/10 (Genoa), AIRC (Milan), PRIN Project (MIUR, Rome), Fondazione Cariplo (Milan), Compagnia di San Paolo (Turin), Fondazione Cassa di Risparmio di Cuneo (Cuneo), Regione Piemonte (Turin), and Associazione “Amici di Jean” (Turin).

PY - 2007/5

Y1 - 2007/5

N2 - Human ICOS is a T cell costimulatory molecule supporting IL10 secretion. A pilot study investigating variations of the ICOS gene 3'UTR detected 8 polymorphisms forming three haplotypes (A, B, C). Haplotype-A and -C displayed the highest difference. Activated T cells from healthy AA homozygotes expressed significantly less ICOS and secreted more IL10 than AC heterozygotes, whereas AB heterozygotes displayed intermediate levels. Analysis of 441 multiple sclerosis patients and 793 controls showed that frequency of AA homozygosity was significantly lower in MS patients with relapsing-remitting onset (N = 416) than in controls (OR = 0.70). Moreover, AA patients with relapsing-remitting onset had lower relapse rate and multiple sclerosis severity score than non-AA patients.

AB - Human ICOS is a T cell costimulatory molecule supporting IL10 secretion. A pilot study investigating variations of the ICOS gene 3'UTR detected 8 polymorphisms forming three haplotypes (A, B, C). Haplotype-A and -C displayed the highest difference. Activated T cells from healthy AA homozygotes expressed significantly less ICOS and secreted more IL10 than AC heterozygotes, whereas AB heterozygotes displayed intermediate levels. Analysis of 441 multiple sclerosis patients and 793 controls showed that frequency of AA homozygosity was significantly lower in MS patients with relapsing-remitting onset (N = 416) than in controls (OR = 0.70). Moreover, AA patients with relapsing-remitting onset had lower relapse rate and multiple sclerosis severity score than non-AA patients.

KW - ICOS

KW - IL10

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=34248673439&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2007.03.022

DO - 10.1016/j.jneuroim.2007.03.022

M3 - Article

SN - 0165-5728

VL - 186

SP - 193

EP - 198

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution

Abstract

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