Hyperpolarized ¹³C-labelled anhydrides as DNP precursors of metabolic MRI agents

Keyphrases

• Metabolic 100%
• MRI Contrast Agent 100%
• 13C Labeling 100%
• Hyperpolarized 13C 100%
• Anhydride 100%
• Dynamic nuclear Polarization 100%
• Short-chain Fatty Acids 80%
• Contrast Agent 40%
• Clinical Potential 40%
• Chemical Precursors 40%
• Symmetric Anhydrides 40%
• Clinical Translation 20%
• Fatty Acids 20%
• Esterified 20%
• Gadolinium Complex 20%
• Pharmaceutical Expenditure 20%
• Novel Class 20%
• Human Disease 20%
• Lipophilic 20%
• Healthy Tissue 20%
• Metabolic Abnormalities 20%
• Labeled Compounds 20%
• Glass Forming 20%
• Promoting Additives 20%
• Research-based 20%
• Polarization Process 20%
• Ischemic Tissue 20%
• Trityl Radical 20%
• Organic Derivatives 20%
• Technical Constraints 20%
• Aqueous Formulations 20%
• In Vivo Detection 20%
• Easy Removal 20%
• Biological Efficacy 20%
• Metabolic Difference 20%
• Nuclear Magnetic Resonance Signal 20%
• Polarization Method 20%

Chemistry

• Magnetic Resonance Imaging 100%
• Metabolic 100%
• Anhydride 100%
• Dynamic Nuclear Polarization 100%
• Short-Chain Fatty Acid 80%
• Contrast Medium 40%
• Gadolinium 20%
• NMR Signal 20%
• Fatty Acids 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Carbon 13 100%
• Acid Anhydride 100%
• Short Chain Fatty Acid 100%
• Contrast Medium 50%
• Fatty Acid 25%
• Gadolinium 25%
• Diseases 25%