Hybrid inorganic (nonporous silica)/organic (alginate) core-shell platform for targeting a cisplatin-based Pt(IV) anticancer prodrug

Mauro Ravera, Elisabetta Gabano, Diego Bonzani, Ilaria Zanellato, Aldo Arrais, Simone Cantamessa, Marco Biggiogera, Domenico Osella

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Nonporous silica nanoparticles with an external shell containing the 3‑aminopropyl arm (SiNP) were further decorated with alginic acid (SiNP-ALG) as a potential biocompatible delivery system for Pt antitumor agents. Such particles were coupled with the prodrug (OC‑6‑44)‑acetato(β‑alaninato)diamminedichloridoplatinum(IV), 1, through the formation of amide bonds between the pendant carboxylate groups on SiNP-ALG and the free amino group of the complex. Cytosol extracted from tumor cells was able to quickly and efficiently reduce the Pt(IV) prodrug, and produces the active metabolite cisplatin. SiNP-ALG-Pt conjugate was more active than both cisplatin and 1, due to its more efficient cell uptake, whereas the SiNP-ALG unplatinated nanoparticles were deprived of any nonspecific toxicity.

Lingua originaleInglese
pagine (da-a)185-191
Numero di pagine7
RivistaJournal of Inorganic Biochemistry
Volume189
DOI
Stato di pubblicazionePubblicato - dic 2018

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