TY - JOUR
T1 - Human herniated inter-vertebral discs
T2 - No evidence of an immune response
AU - Rizzo, E.
AU - Navone, R.
AU - Cannas, M.
PY - 1998
Y1 - 1998
N2 - Many previous authors have reported morphological and histochemical observations on the nucleus pulposus in human herniated discs. It has been implied that an autoimmune response may be a cause of tissue damage, or may maintain the process involved in the invertebral disc herniation and consequent back pain. In a preliminary study we have now evaluated the presence of HLA-DR antigens in nucleus pulposus frozen sections and the presence of endothelial cells, by the use of antibodies against the von Willebrand factor. The results, on samples from 11 patients, showed only a few feeble HLA-DR antigen-positive cells in one case and no positivity for the von Willebrand factor. Therefore, on the basis of the results in this study, it may be said that an HLA-DR mediated auto-immune mechanism in human discal herniation is unlikely.
AB - Many previous authors have reported morphological and histochemical observations on the nucleus pulposus in human herniated discs. It has been implied that an autoimmune response may be a cause of tissue damage, or may maintain the process involved in the invertebral disc herniation and consequent back pain. In a preliminary study we have now evaluated the presence of HLA-DR antigens in nucleus pulposus frozen sections and the presence of endothelial cells, by the use of antibodies against the von Willebrand factor. The results, on samples from 11 patients, showed only a few feeble HLA-DR antigen-positive cells in one case and no positivity for the von Willebrand factor. Therefore, on the basis of the results in this study, it may be said that an HLA-DR mediated auto-immune mechanism in human discal herniation is unlikely.
KW - Auto-immunity
KW - Inter-vertebral disc herniation,
KW - Nucleus pulposus
UR - http://www.scopus.com/inward/record.url?scp=0031875611&partnerID=8YFLogxK
M3 - Article
SN - 0269-8951
VL - 26
SP - 381
EP - 384
JO - Medical Science Research
JF - Medical Science Research
IS - 6
ER -