Hormonal modulation of GM-CSF receptor alpha-chain in in vitro models of endometrial cancer

G. Baj; A. Arnulfo; R. Boldorini; G. Nicosia; L. Villa; F. Malavasi; N. Surico; Deniz Yalman

Hormonal modulation of GM-CSF receptor alpha-chain in in vitro models of endometrial cancer

G. Baj, A. Arnulfo, R. Boldorini, G. Nicosia, L. Villa, F. Malavasi, N. Surico, Deniz Yalman

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that stimulates the proliferation and differentiation of bone marrow progenitors. Moreover, the presence and activity of GM-CSF and its receptor (GM-CSF-r) has been documented on tissues and cell lines of a non-hemopoietic origin. In this paper we studied the expression and putative role of GM-CSF and GM-CSF-r in endometrial cancer. The modulation of GM-CSF-r alpha-chain upon progesterone treatment suggests a role for GM-CSF and its receptor in the pathogenesis and development of endometriial cancer.

Lingua originale	Inglese
pagine (da-a)	305-308
Numero di pagine	4
Rivista	European Journal of Gynaecological Oncology
Volume	21
Numero di pubblicazione	3
Stato di pubblicazione	Pubblicato - 2000

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abstract = "Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that stimulates the proliferation and differentiation of bone marrow progenitors. Moreover, the presence and activity of GM-CSF and its receptor (GM-CSF-r) has been documented on tissues and cell lines of a non-hemopoietic origin. In this paper we studied the expression and putative role of GM-CSF and GM-CSF-r in endometrial cancer. The modulation of GM-CSF-r alpha-chain upon progesterone treatment suggests a role for GM-CSF and its receptor in the pathogenesis and development of endometriial cancer.",

keywords = "Endometrial cancer, GM-CSF receptor, Progesterone",

author = "G. Baj and A. Arnulfo and R. Boldorini and G. Nicosia and L. Villa and F. Malavasi and N. Surico and Deniz Yalman",

year = "2000",

language = "English",

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TY - JOUR

T1 - Hormonal modulation of GM-CSF receptor alpha-chain in in vitro models of endometrial cancer

AU - Baj, G.

AU - Arnulfo, A.

AU - Boldorini, R.

AU - Nicosia, G.

AU - Villa, L.

AU - Malavasi, F.

AU - Surico, N.

AU - Yalman, Deniz

PY - 2000

Y1 - 2000

N2 - Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that stimulates the proliferation and differentiation of bone marrow progenitors. Moreover, the presence and activity of GM-CSF and its receptor (GM-CSF-r) has been documented on tissues and cell lines of a non-hemopoietic origin. In this paper we studied the expression and putative role of GM-CSF and GM-CSF-r in endometrial cancer. The modulation of GM-CSF-r alpha-chain upon progesterone treatment suggests a role for GM-CSF and its receptor in the pathogenesis and development of endometriial cancer.

AB - Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that stimulates the proliferation and differentiation of bone marrow progenitors. Moreover, the presence and activity of GM-CSF and its receptor (GM-CSF-r) has been documented on tissues and cell lines of a non-hemopoietic origin. In this paper we studied the expression and putative role of GM-CSF and GM-CSF-r in endometrial cancer. The modulation of GM-CSF-r alpha-chain upon progesterone treatment suggests a role for GM-CSF and its receptor in the pathogenesis and development of endometriial cancer.

KW - Endometrial cancer

KW - GM-CSF receptor

KW - Progesterone

UR - http://www.scopus.com/inward/record.url?scp=0033927506&partnerID=8YFLogxK

M3 - Article

SN - 0392-2936

VL - 21

SP - 305

EP - 308

JO - European Journal of Gynaecological Oncology

JF - European Journal of Gynaecological Oncology

IS - 3

ER -

Hormonal modulation of GM-CSF receptor alpha-chain in in vitro models of endometrial cancer

Abstract

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