TY - JOUR
T1 - Homologues and isomers of noladin ether, a putative novel endocannabinoid
T2 - Interaction with rat cannabinoid CB1 receptors
AU - Appendino, Giovanni
AU - Ligresti, Alessia
AU - Minassi, Alberto
AU - Daddario, Nives
AU - Bisogno, Tiziana
AU - Di Marzo, Vincenzo
N1 - Funding Information:
We are grateful to Chemi (Cinisello Balsamo, MI, Italy) for a generous gift of d - and l -solketal, and to Giuseppe Guilla for his help in the synthesis of several glyceryl ethers. Support from MURST (grant 3933 to V.D.M.) is acknowledged.
PY - 2003/1/6
Y1 - 2003/1/6
N2 - Two regioisomers and 13 analogues of the putative endocannabinoid noladin ether (2-arachidonyl glyceryl ether, 2-AGE, 1) were synthesized and tested for their interaction with CB1 receptors in rat brain membranes. The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB1 receptors.
AB - Two regioisomers and 13 analogues of the putative endocannabinoid noladin ether (2-arachidonyl glyceryl ether, 2-AGE, 1) were synthesized and tested for their interaction with CB1 receptors in rat brain membranes. The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB1 receptors.
UR - http://www.scopus.com/inward/record.url?scp=1842864772&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(02)00839-9
DO - 10.1016/S0960-894X(02)00839-9
M3 - Article
SN - 0960-894X
VL - 13
SP - 43
EP - 46
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 1
ER -