Homologues and isomers of noladin ether, a putative novel endocannabinoid: Interaction with rat cannabinoid CB1 receptors

Giovanni Appendino, Alessia Ligresti, Alberto Minassi, Nives Daddario, Tiziana Bisogno, Vincenzo Di Marzo

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Two regioisomers and 13 analogues of the putative endocannabinoid noladin ether (2-arachidonyl glyceryl ether, 2-AGE, 1) were synthesized and tested for their interaction with CB1 receptors in rat brain membranes. The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB1 receptors.

Lingua originaleInglese
pagine (da-a)43-46
Numero di pagine4
RivistaBioorganic and Medicinal Chemistry Letters
Volume13
Numero di pubblicazione1
DOI
Stato di pubblicazionePubblicato - 6 gen 2003

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