HLA supratypes in an Italian population

Sandra D'Alfonso; Nazario Cappello; Iolanda Borelli; Gina Mazzola; Daniela Peruccio; Mara Giordano; Isabella Cascino; Roberto Tosi; Patricia Momigliano Richiardi

doi:10.1007/BF00188614

HLA supratypes in an Italian population

Sandra D'Alfonso, Nazario Cappello, Iolanda Borelli, Gina Mazzola, Daniela Peruccio, Mara Giordano, Isabella Cascino, Roberto Tosi, Patricia Momigliano Richiardi

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A supratype analysis of a North Italian population was performed, using 16 polymorphisms in the HLA region spanning the HLA-A-DP segment. Fourteen supratypes were identified, mostly corresponding to those found in other Caucasiod populations. The degree of their conservation both within the B-DR/DQ region and in the regions telomeric and centromeric from HLA-A and DP was evaluated and linkage disequilibria among several DR and DP alleles were identified. Notably, the degree of association with DP increased when the DR marker was part of a conserved B-DR/DQ supratype. These data are relevant to the definition of the genetic structure of the population and to the prediction of probabilities of histocompatibility matching between unrelated individuals.

Lingua originale	Inglese
pagine (da-a)	114-120
Numero di pagine	7
Rivista	Immunogenetics
Volume	39
Numero di pubblicazione	2
DOI	https://doi.org/10.1007/BF00188614
Stato di pubblicazione	Pubblicato - gen 1994
Pubblicato esternamente	Sì

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title = "HLA supratypes in an Italian population",

abstract = "A supratype analysis of a North Italian population was performed, using 16 polymorphisms in the HLA region spanning the HLA-A-DP segment. Fourteen supratypes were identified, mostly corresponding to those found in other Caucasiod populations. The degree of their conservation both within the B-DR/DQ region and in the regions telomeric and centromeric from HLA-A and DP was evaluated and linkage disequilibria among several DR and DP alleles were identified. Notably, the degree of association with DP increased when the DR marker was part of a conserved B-DR/DQ supratype. These data are relevant to the definition of the genetic structure of the population and to the prediction of probabilities of histocompatibility matching between unrelated individuals.",

author = "Sandra D'Alfonso and Nazario Cappello and Iolanda Borelli and Gina Mazzola and Daniela Peruccio and Mara Giordano and Isabella Cascino and Roberto Tosi and Richiardi, {Patricia Momigliano}",

year = "1994",

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doi = "10.1007/BF00188614",

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AU - D'Alfonso, Sandra

AU - Cappello, Nazario

AU - Borelli, Iolanda

AU - Mazzola, Gina

AU - Peruccio, Daniela

AU - Giordano, Mara

AU - Cascino, Isabella

AU - Tosi, Roberto

AU - Richiardi, Patricia Momigliano

PY - 1994/1

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N2 - A supratype analysis of a North Italian population was performed, using 16 polymorphisms in the HLA region spanning the HLA-A-DP segment. Fourteen supratypes were identified, mostly corresponding to those found in other Caucasiod populations. The degree of their conservation both within the B-DR/DQ region and in the regions telomeric and centromeric from HLA-A and DP was evaluated and linkage disequilibria among several DR and DP alleles were identified. Notably, the degree of association with DP increased when the DR marker was part of a conserved B-DR/DQ supratype. These data are relevant to the definition of the genetic structure of the population and to the prediction of probabilities of histocompatibility matching between unrelated individuals.

AB - A supratype analysis of a North Italian population was performed, using 16 polymorphisms in the HLA region spanning the HLA-A-DP segment. Fourteen supratypes were identified, mostly corresponding to those found in other Caucasiod populations. The degree of their conservation both within the B-DR/DQ region and in the regions telomeric and centromeric from HLA-A and DP was evaluated and linkage disequilibria among several DR and DP alleles were identified. Notably, the degree of association with DP increased when the DR marker was part of a conserved B-DR/DQ supratype. These data are relevant to the definition of the genetic structure of the population and to the prediction of probabilities of histocompatibility matching between unrelated individuals.

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JO - Immunogenetics

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HLA supratypes in an Italian population

Abstract

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